Table 1.

Suggested baseline investigations for anemia in patients with cancer receiving chemotherapy

Suggested investigation
Thorough drug exposure history 
Review of a peripheral blood smear* 
Analyses, where indicated, for iron, total iron-binding capacity, transferrin saturation, ferritin, folate, vitamin B12, or hemoglobinopathy screening 
Assessment of reticulocyte count, occult blood loss, and renal Insufficiency 
Baseline erythropoietin level 
Testing of serum thyroid-stimulating hormone level, where indicated 
Investigations may also include direct antiglobulin testing (eg, Coombs test) for patients with chronic lymphocytic leukemia, non-Hodgkin lymphoma, or a history of autoimmune disease 
Suggested investigation
Thorough drug exposure history 
Review of a peripheral blood smear* 
Analyses, where indicated, for iron, total iron-binding capacity, transferrin saturation, ferritin, folate, vitamin B12, or hemoglobinopathy screening 
Assessment of reticulocyte count, occult blood loss, and renal Insufficiency 
Baseline erythropoietin level 
Testing of serum thyroid-stimulating hormone level, where indicated 
Investigations may also include direct antiglobulin testing (eg, Coombs test) for patients with chronic lymphocytic leukemia, non-Hodgkin lymphoma, or a history of autoimmune disease 

Suggestions are based on the consensus of the Expert Panel. This is not intended to be a comprehensive list of investigations.

*

And in some cases, a bone marrow examination.

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