Table 2.

Predictive ability of the 3-gene PI in univariate and multivariate Cox regression analyses (AML discovery series)

VariableHR (95% CI)Pβ coefficient
Univariate Cox proportional hazard (OS)   
 t(8;21)(q22;q22) 0.440 (0.277-0.699) .001 −0.821 
 inv(16)(p13q22) 0.417 (0.262-0.662) .000 −0.875 
KMT2A rearrangement (11q23) 1.317 (0.912-1.900) .142 0.275 
 t(9;11)(p22;q23) 0.963 (0.554-1.674) .894 −0.038 
 inv(3)(q21q26)/t(3;3)(q21;q26) 3.200 (1.899-5.392) .000 1.163 
NPM1 mutation 0.811 (0.650-1.012) .063 −0.210 
FLT3 ITD 1.561 (1.264-1.930) .000 0.446 
CEBPA biallelic mutations 0.437 (0.246- 0.777) .005 −0.828 
 Age 1.017 (1.009-1.025) .000 0.017 
 Cytogenetic risk group (ELN) 1.678 (1.481-1.902) .000 0.518 
 PI 2.718 (2.205-3.351) .000 1.000 
 WHO performance status 1.004 (0.936-1.077) .903 0.004 
Multivariate Cox proportional hazard (OS)   
 t(8;21)(q22;q22) 0.545 (0.262-1.131) .103 −0.607 
 inv(16)(p13q22) 0.334 (0.161-0.695) .003 −1.095 
KMT2A rearrangement (11q23) 2.342 (1.171-4.680) .016 0.851 
 t(9;11)(p22;q23) 0.695 (0.337-1.435) .325 −0.364 
 inv(3)(q21q26)/t(3;3)(q21;q26) 2.256 (1.138-4.471) .020 0.813 
NPM1 mutation 0.508 (0.282-0.912) .023 −0.678 
FLT3 ITD 1.893 (1.078-3.324) .026 0.638 
CEBPA biallelic mutations 0.374 (0.177-0.790) .010 −0.984 
 Age 1.014 (1.006-1.023) .000 0.014 
 ELN cytogenetic risk group 0.790 (0.467-1.335) .379 −0.236 
 PI 2.002 (1.542-2.601) .000 0.694 
 WHO performance status 1.041 (0.969-1.119) .270 0.041 
VariableHR (95% CI)Pβ coefficient
Univariate Cox proportional hazard (OS)   
 t(8;21)(q22;q22) 0.440 (0.277-0.699) .001 −0.821 
 inv(16)(p13q22) 0.417 (0.262-0.662) .000 −0.875 
KMT2A rearrangement (11q23) 1.317 (0.912-1.900) .142 0.275 
 t(9;11)(p22;q23) 0.963 (0.554-1.674) .894 −0.038 
 inv(3)(q21q26)/t(3;3)(q21;q26) 3.200 (1.899-5.392) .000 1.163 
NPM1 mutation 0.811 (0.650-1.012) .063 −0.210 
FLT3 ITD 1.561 (1.264-1.930) .000 0.446 
CEBPA biallelic mutations 0.437 (0.246- 0.777) .005 −0.828 
 Age 1.017 (1.009-1.025) .000 0.017 
 Cytogenetic risk group (ELN) 1.678 (1.481-1.902) .000 0.518 
 PI 2.718 (2.205-3.351) .000 1.000 
 WHO performance status 1.004 (0.936-1.077) .903 0.004 
Multivariate Cox proportional hazard (OS)   
 t(8;21)(q22;q22) 0.545 (0.262-1.131) .103 −0.607 
 inv(16)(p13q22) 0.334 (0.161-0.695) .003 −1.095 
KMT2A rearrangement (11q23) 2.342 (1.171-4.680) .016 0.851 
 t(9;11)(p22;q23) 0.695 (0.337-1.435) .325 −0.364 
 inv(3)(q21q26)/t(3;3)(q21;q26) 2.256 (1.138-4.471) .020 0.813 
NPM1 mutation 0.508 (0.282-0.912) .023 −0.678 
FLT3 ITD 1.893 (1.078-3.324) .026 0.638 
CEBPA biallelic mutations 0.374 (0.177-0.790) .010 −0.984 
 Age 1.014 (1.006-1.023) .000 0.014 
 ELN cytogenetic risk group 0.790 (0.467-1.335) .379 −0.236 
 PI 2.002 (1.542-2.601) .000 0.694 
 WHO performance status 1.041 (0.969-1.119) .270 0.041 

The following categorical and continuous variables were evaluated in univariate Cox proportional hazard models for outcome: age, cytogenetic risk group (1 = favorable, 2 = intermediate, 3 = adverse), prognostic chromosomal abnormalities and molecular lesions, performance status, and PI. HRs > 1 or HRs < 1 indicate, respectively, higher or lower risk of event for higher values of continuous variables and for first category listed for categorical variables in OS models. Bold type denotes statistically significant P values.

CI, confidence interval; ELN, European LeukemiaNet; HR, hazard ratio.

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