Two-year OS, NRM, and relapse incidence by score
| Score . | Level . | OS . | NRM . | Relapse incidence . | |||
|---|---|---|---|---|---|---|---|
| 2-y OS, % (range) . | Log-rank P . | 2-y NRM, % (range) . | Gray P . | 2-y RI, % (range) . | Gray P . | ||
| HCT-CI | 0 | 50.1 (40.7-61.8) | 15.3 (9.5-24.6) | 34.4 (26.1-45.3) | |||
| 1-2 | 60.2 (53.4-67.9) | 18.6 (13.8-25.0) | 24.8 (19.2-31.9) | ||||
| 3+ | 46.5 (40.2-53.7) | .037 | 24.7 (19.6-31.1) | .203 | 30.7 (25.2-37.3) | .174 | |
| Comorbidity-Age | 0 | 69.6 (55.3-87.6) | 11.1 (4.4-28.0) | 22.4 (11.5-43.7) | |||
| 1-2 | 55.8 (48.8-63.7) | 17.0 (12.3-23.3) | 28.3 (22.6-35.5) | ||||
| 3-4 | 55.7 (48.5-64.0) | 18.9 (13.7-26.0) | 27.6 (21.5-35.3) | ||||
| 5+ | 36.6 (28.6-46.8) | <.001 | 31.3 (24.0-40.9) | .006 | 34.8 (27.3-44.3) | .389 | |
| Comorbidity-EBMT | 0/<4 | 49.9 (38.0-65.7) | 14.6 (8.0-26.7) | 34.3 (23.9-49.3) | |||
| 0/≥4 | 50.1 (36.1-69.7) | 16.4 (7.7-34.9) | 34.6 (22.6-52.9) | ||||
| I-II/<4 | 66.4 (57.4-76.8) | 16.1 (10.1-25.5) | 23.0 (15.7-33.6) | ||||
| I-II/≥4 | 53.9 (44.3-65.6) | 21.1 (14.3-31.1) | 26.5 (18.9-37.1) | ||||
| III+/<4 | 56.3 (47.1-67.3) | 16.3 (10.4-25.7) | 28.8 (21.3-38.9) | ||||
| III+/≥4 | 38.1 (30.2-48.0) | .001 | 31.7 (24.4-41.1) | .019 | 32.3 (25.0-41.7) | .531 | |
| EBMT | 0-2 | 63.0 (54.7-72.6) | 15.9 (10.5-24.1) | 25.3 (18.5-34.5) | |||
| 3 | 54.4 (46.3-64.0) | 16.0 (10.7-23.8) | 30.1 (18.5-34.5) | ||||
| 4 | 46.5 (38.0-56.9) | 24.3 (17.5-33.6) | 30.1 (22.9-39.6) | ||||
| 5 | 46.5 (36.5-59.2) | 22.0 (14.6-33.1) | 34.6 (25.7-46.7) | ||||
| 6-7 | 43.9 (32.6-59.2) | .007 | 32.5 (22.4-47.1) | .046 | 25.9 (16.7-40.1) | .346 | |
| rDRI | Low | 72.7 (57.1-92.6) | 15.9 (6.4-39.5) | 15.0 (6.0-37.4) | |||
| Intermediate | 61.4 (55.8-67.5) | 16.2 (12.4-21.2) | 23.6 (19.1-29.1) | ||||
| High | 32.1 (24.9-41.3) | 26.5 (20.1-35.0) | 44.9 (37.4-54.0) | ||||
| Very high | 31.5 (19.5-50.7) | <.001 | 33.5 (21.5-52.3) | .024 | 35.9 (23.6-54.6) | <.001 | |
| PAM | <15 | 64.6 (56.8-73.5) | 12.5 (8.0-19.5) | 24.7 (18.3-33.3) | |||
| 15-20 | 59.7 (51.4-69.3) | 16.6 (11.0-25.0) | 24.4 (18.0-33.1) | ||||
| 20-25 | 47.2 (38.8-57.6) | 22.4 (16.0-31.2) | 35.6 (28.0-45.3) | ||||
| >25 | 35.0 (27.5-44.7) | <.001 | 32.4 (25.2-41.7) | .001 | 33.2 (25.9-42.5) | .036 | |
| rPAM | <12.3 | 71.2 (63.6-79.7) | 12.1 (7.5-19.5) | 17.7 (12.2-25.7) | |||
| 12.3-16.5 | 61.0 (52.2-71.2) | 15.5 (10.0-24.0) | 24.0 (17.2-33.6) | ||||
| 16.6-21.9 | 42.5 (34.0-53.0) | 23.9 (17.3-33.1) | 36.0 (28.2-45.9) | ||||
| >21.9 | 35.7 (27.8-46.0) | <.001 | 34.4 (26.8-44.2) | <.001 | 33.7 (26.1-43.4) | .003 | |
| EASIx | <0.89 | 66.1 (58.2-75.1) | 11.1 (6.7-18.2) | 26 (19.3-34.9) | |||
| 0.89-1.40 | 54.8 (46.4-64.7) | 11.3 (6.9-18.6) | 35.3 (27.8-44.8) | ||||
| 1.40-3.76 | 49.0 (40.9-58.7) | 27.8 (21.0-36.9 | 26.2 (19.7-34.9) | ||||
| >3.76 | 38.8 (30.9-48.6) | <.001 | 32.0 (24.8-41.2) | <.001 | 29.6 (22.6-38.6) | .377 | |
| Score . | Level . | OS . | NRM . | Relapse incidence . | |||
|---|---|---|---|---|---|---|---|
| 2-y OS, % (range) . | Log-rank P . | 2-y NRM, % (range) . | Gray P . | 2-y RI, % (range) . | Gray P . | ||
| HCT-CI | 0 | 50.1 (40.7-61.8) | 15.3 (9.5-24.6) | 34.4 (26.1-45.3) | |||
| 1-2 | 60.2 (53.4-67.9) | 18.6 (13.8-25.0) | 24.8 (19.2-31.9) | ||||
| 3+ | 46.5 (40.2-53.7) | .037 | 24.7 (19.6-31.1) | .203 | 30.7 (25.2-37.3) | .174 | |
| Comorbidity-Age | 0 | 69.6 (55.3-87.6) | 11.1 (4.4-28.0) | 22.4 (11.5-43.7) | |||
| 1-2 | 55.8 (48.8-63.7) | 17.0 (12.3-23.3) | 28.3 (22.6-35.5) | ||||
| 3-4 | 55.7 (48.5-64.0) | 18.9 (13.7-26.0) | 27.6 (21.5-35.3) | ||||
| 5+ | 36.6 (28.6-46.8) | <.001 | 31.3 (24.0-40.9) | .006 | 34.8 (27.3-44.3) | .389 | |
| Comorbidity-EBMT | 0/<4 | 49.9 (38.0-65.7) | 14.6 (8.0-26.7) | 34.3 (23.9-49.3) | |||
| 0/≥4 | 50.1 (36.1-69.7) | 16.4 (7.7-34.9) | 34.6 (22.6-52.9) | ||||
| I-II/<4 | 66.4 (57.4-76.8) | 16.1 (10.1-25.5) | 23.0 (15.7-33.6) | ||||
| I-II/≥4 | 53.9 (44.3-65.6) | 21.1 (14.3-31.1) | 26.5 (18.9-37.1) | ||||
| III+/<4 | 56.3 (47.1-67.3) | 16.3 (10.4-25.7) | 28.8 (21.3-38.9) | ||||
| III+/≥4 | 38.1 (30.2-48.0) | .001 | 31.7 (24.4-41.1) | .019 | 32.3 (25.0-41.7) | .531 | |
| EBMT | 0-2 | 63.0 (54.7-72.6) | 15.9 (10.5-24.1) | 25.3 (18.5-34.5) | |||
| 3 | 54.4 (46.3-64.0) | 16.0 (10.7-23.8) | 30.1 (18.5-34.5) | ||||
| 4 | 46.5 (38.0-56.9) | 24.3 (17.5-33.6) | 30.1 (22.9-39.6) | ||||
| 5 | 46.5 (36.5-59.2) | 22.0 (14.6-33.1) | 34.6 (25.7-46.7) | ||||
| 6-7 | 43.9 (32.6-59.2) | .007 | 32.5 (22.4-47.1) | .046 | 25.9 (16.7-40.1) | .346 | |
| rDRI | Low | 72.7 (57.1-92.6) | 15.9 (6.4-39.5) | 15.0 (6.0-37.4) | |||
| Intermediate | 61.4 (55.8-67.5) | 16.2 (12.4-21.2) | 23.6 (19.1-29.1) | ||||
| High | 32.1 (24.9-41.3) | 26.5 (20.1-35.0) | 44.9 (37.4-54.0) | ||||
| Very high | 31.5 (19.5-50.7) | <.001 | 33.5 (21.5-52.3) | .024 | 35.9 (23.6-54.6) | <.001 | |
| PAM | <15 | 64.6 (56.8-73.5) | 12.5 (8.0-19.5) | 24.7 (18.3-33.3) | |||
| 15-20 | 59.7 (51.4-69.3) | 16.6 (11.0-25.0) | 24.4 (18.0-33.1) | ||||
| 20-25 | 47.2 (38.8-57.6) | 22.4 (16.0-31.2) | 35.6 (28.0-45.3) | ||||
| >25 | 35.0 (27.5-44.7) | <.001 | 32.4 (25.2-41.7) | .001 | 33.2 (25.9-42.5) | .036 | |
| rPAM | <12.3 | 71.2 (63.6-79.7) | 12.1 (7.5-19.5) | 17.7 (12.2-25.7) | |||
| 12.3-16.5 | 61.0 (52.2-71.2) | 15.5 (10.0-24.0) | 24.0 (17.2-33.6) | ||||
| 16.6-21.9 | 42.5 (34.0-53.0) | 23.9 (17.3-33.1) | 36.0 (28.2-45.9) | ||||
| >21.9 | 35.7 (27.8-46.0) | <.001 | 34.4 (26.8-44.2) | <.001 | 33.7 (26.1-43.4) | .003 | |
| EASIx | <0.89 | 66.1 (58.2-75.1) | 11.1 (6.7-18.2) | 26 (19.3-34.9) | |||
| 0.89-1.40 | 54.8 (46.4-64.7) | 11.3 (6.9-18.6) | 35.3 (27.8-44.8) | ||||
| 1.40-3.76 | 49.0 (40.9-58.7) | 27.8 (21.0-36.9 | 26.2 (19.7-34.9) | ||||
| >3.76 | 38.8 (30.9-48.6) | <.001 | 32.0 (24.8-41.2) | <.001 | 29.6 (22.6-38.6) | .377 | |