Predictors for 5-year bleeding in joints with absent or limited abnormalities on baseline radiographs
| Predictor . | Unadjusted . | Adjusted* . | |
|---|---|---|---|
| Severe hemophilia and prophylaxis . | Moderate hemophilia and on demand . | Overall† . | |
| N | 55 | 32 | 92 |
| Severe hemophilia | — | — | 0.7 (0.2-2.5) |
| Prophylactic treatment | — | — | — |
| Lifetime number of bleeds at joint level ≥3 | 2.9 (0.9-9.3) | 1.1 (0.3-4.6) | 1.8 (0.7-4.4) |
| MRI findings | |||
| Effusion | 1.0 (0.3-3.7) | 0.5 (0.0-5.6) | — |
| Synovial hypertrophy | 18.0 (2.0-165.0)‡ | 9.0 (0.9-10.2) | 10.1 (3.4-31.3)‡ |
| Osteochondral changes | 10.2 (1.1-100.2)‡ | 3.0 (0.4-21.3) | — |
| Predictor . | Unadjusted . | Adjusted* . | |
|---|---|---|---|
| Severe hemophilia and prophylaxis . | Moderate hemophilia and on demand . | Overall† . | |
| N | 55 | 32 | 92 |
| Severe hemophilia | — | — | 0.7 (0.2-2.5) |
| Prophylactic treatment | — | — | — |
| Lifetime number of bleeds at joint level ≥3 | 2.9 (0.9-9.3) | 1.1 (0.3-4.6) | 1.8 (0.7-4.4) |
| MRI findings | |||
| Effusion | 1.0 (0.3-3.7) | 0.5 (0.0-5.6) | — |
| Synovial hypertrophy | 18.0 (2.0-165.0)‡ | 9.0 (0.9-10.2) | 10.1 (3.4-31.3)‡ |
| Osteochondral changes | 10.2 (1.1-100.2)‡ | 3.0 (0.4-21.3) | — |
Data are presented as ORs (95% CIs).
Adjusted for severity of disease, baseline joint bleeding history, and synovial hypertrophy.
Including 2 joints of 1 patient with severe hemophilia treated on demand, and 3 joints of 1 patient with moderate hemophilia on prophylaxis.
Significant predictor for 5-year bleeding.