Table 1. Human TAN and PMN-MDSC protumor... | American Society of Hematology

Table 1.

Human TAN and PMN-MDSC protumor and antitumor functions

	TANs/PMN-MDSCs	Reference		T-cell suppression confirmed in humans
	TANs/PMN-MDSCs	TANs	PMN-MDSCs	T-cell suppression confirmed in humans
Protumor
T/NK cell suppression
Arginase 1	TANs, PMN-MDSCs	59	74,82,-84,91	Yes
ROS	TANs, PMN-MDSCs	92	84,85	No
STAT3	PMN-MDSCs		93	Yes
STAT/IRF-8	PMN-MDSCs		78	No
LOX-1	PMN-MDSCs		89,90	Yes
mPR3	TANs	61		N/A
MPO/hydrogen peroxide	TANs	62,63		N/A
Angiogenesis/metastasis
VEGF	TANs, PMN-MDSCs	94	83	Yes
MMP9	TANs, PMN-MDSCs	34,95	88	Yes
NAMPT/STAT3	TANs	36		N/A
Oncostatin M	TANs	45,46		N/A
NETs	TANs	38		N/A
TNF-α	TANs	55		N/A
IL-8	TANs	43,44,59		N/A
Elastase	TANs	37		N/A
Immune cell recruitment
CCL17	TANs	39,40		N/A
CCL2	TANs	39		N/A
Antitumor
Tumor cytotoxicity
ROS	TAN	30,96		N/A
Granzyme B	TAN	97		N/A
MET signaling	TAN	32		N/A
Trogoptosis	TAN	52		N/A
TNF-α	TAN	32,53		N/A
T-cell activation/priming
Mechanism unknown	TAN	48,98		N/A
NETs	TAN	49		N/A

	TANs/PMN-MDSCs	Reference		T-cell suppression confirmed in humans
	TANs/PMN-MDSCs	TANs	PMN-MDSCs	T-cell suppression confirmed in humans
Protumor
T/NK cell suppression
Arginase 1	TANs, PMN-MDSCs	59	74,82,-84,91	Yes
ROS	TANs, PMN-MDSCs	92	84,85	No
STAT3	PMN-MDSCs		93	Yes
STAT/IRF-8	PMN-MDSCs		78	No
LOX-1	PMN-MDSCs		89,90	Yes
mPR3	TANs	61		N/A
MPO/hydrogen peroxide	TANs	62,63		N/A
Angiogenesis/metastasis
VEGF	TANs, PMN-MDSCs	94	83	Yes
MMP9	TANs, PMN-MDSCs	34,95	88	Yes
NAMPT/STAT3	TANs	36		N/A
Oncostatin M	TANs	45,46		N/A
NETs	TANs	38		N/A
TNF-α	TANs	55		N/A
IL-8	TANs	43,44,59		N/A
Elastase	TANs	37		N/A
Immune cell recruitment
CCL17	TANs	39,40		N/A
CCL2	TANs	39		N/A
Antitumor
Tumor cytotoxicity
ROS	TAN	30,96		N/A
Granzyme B	TAN	97		N/A
MET signaling	TAN	32		N/A
Trogoptosis	TAN	52		N/A
TNF-α	TAN	32,53		N/A
T-cell activation/priming
Mechanism unknown	TAN	48,98		N/A
NETs	TAN	49		N/A

LOX-1, low-density lipoprotein receptor-1; mPR3, membrane-associated proteinase 3; N/A, not applicable; NAMPT, nicotinamide phosphoribosyltransferase; NET, neutrophil extracellular trap; STAT3, signal transducer and activator of transcription 3; TNF-α, tumor necrosis factor α; VEGF, vascular endothelial growth factor.

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