SIR and EAR (per 1000 person-years) for all SMNs and by risk factors
| Risk factors . | Observed . | Expected . | SIR (95% CI) . | EAR (95% CI) . |
|---|---|---|---|---|
| All SMNs | 581 | 205 | 2.8 (2.6, 3.1) | 7.5 (6.5, 8.6) |
| Sex | ||||
| Male | 297 | 116.9 | 2.5 (2.2, 2.9) | 6.5 (5.3, 7.9) |
| Female | 284 | 88.1 | 3.2 (2.8, 3.7) | 8.8 (7.3, 10.6) |
| Age at first allogeneic HCT, y | ||||
| ≤20 y | 110 | 8.8 | 12.5 (10.2, 15.3) | 10.6 (5.9, 16.7) |
| >20-50 y | 327 | 112.1 | 2.9 (2.6, 3.3) | 13.4 (8.8, 20.1) |
| >50 y | 144 | 84.1 | 1.7 (1.4, 2.0) | 8.6 (6.7, 10.8) |
| HCT diagnosis category | ||||
| Nonmalignant disorder | 34 | 13.2 | 2.6 (1.8, 3.7) | 8.0 (5.2, 11.5) |
| Hematologic/lymphoid malignancy | 547 | 191.8 | 2.9 (2.6, 3.1) | 8.7 (6.3, 11.7) |
| Preparative regimen | ||||
| Chemotherapy only | 144 | 75.9 | 1.9 (1.6, 2.3) | 6.9 (5.9, 8.03) |
| Low-dose TBI 200-450 cGy | 63 | 31.1 | 2.0 (1.6, 2.6) | 4.2 (2.7, 5.9) |
| Single-dose TBI 600-1000 cGy | 37 | 4.7 | 7.8 (5.5, 11.2) | 8.6 (6.8, 10.7) |
| Fractionated TBI 600-1200 cGy | 183 | 56.4 | 3.3 (2.8, 3.8) | 7.6 (5.5, 10.1) |
| Fractionated TBI 1320-1400 cGy | 68 | 22 | 3.1 (2.4, 4.0) | 7.6 (5.1, 10.5) |
| Fractionated TBI 1440-1750 cGy | 81 | 14.2 | 5.7 (4.5, 7.3) | 4.9 (3.2, 6.8) |
| Stem cell source | ||||
| BM | 431 | 143.6 | 3.0 (2.7, 3.3) | 10.6 (7.7, 14.1) |
| PBSC/BM+PBSC | 144 | 60.7 | 2.4 (2.0, 2.8) | 11.6 (4.1, 29.1) |
| Cord | 6 | 0.7 | 8.7 (3.7, 20.4) | 3.2 (1.6, 55) |
| GVHD status* | ||||
| None | 91 | 34.7 | 2.6 (2.1, 3.3) | 5.1 (3.4, 7.2) |
| Acute only | 100 | 32.4 | 31 (25, 3.8) | 7.6 (5.4, 10.2) |
| Chronic (± acute) | 353 | 131.6 | 3.0 (2.4, 3.0) | 8.2 (6.8, 9.7) |
| Follow-up time after first allogeneic HCT,*y | ||||
| ≤10 | 396 | 142.1 | 2.8 (2.5, 3.1) | 6.8 (5.7, 8.0) |
| >10-20 | 119 | 44.3 | 2.7 (2.2, 3.3) | 8.0 (5.7, 10.7) |
| >20-30 | 59 | 16.5 | 3.6 (2.7, 4.7) | 13.5 (9.0, 19.44) |
| >30 | 7 | 2 | 3.4 (1.7, 7.2) | 13.7 (3.6, 34.7) |
| Current age,*y | ||||
| ≤20 | 37 | 1.2 | 30.9 (22.6, 42.4) | 5.4 (3.9, 7.5) |
| >20-50 | 239 | 53 | 4.5 (3.9, 5.2) | 6.4 (5.3, 7.5) |
| >50 | 305 | 150.8 | 2.0 (1.8, 2.3) | 10.9 (8.5, 13.7) |
| Risk factors . | Observed . | Expected . | SIR (95% CI) . | EAR (95% CI) . |
|---|---|---|---|---|
| All SMNs | 581 | 205 | 2.8 (2.6, 3.1) | 7.5 (6.5, 8.6) |
| Sex | ||||
| Male | 297 | 116.9 | 2.5 (2.2, 2.9) | 6.5 (5.3, 7.9) |
| Female | 284 | 88.1 | 3.2 (2.8, 3.7) | 8.8 (7.3, 10.6) |
| Age at first allogeneic HCT, y | ||||
| ≤20 y | 110 | 8.8 | 12.5 (10.2, 15.3) | 10.6 (5.9, 16.7) |
| >20-50 y | 327 | 112.1 | 2.9 (2.6, 3.3) | 13.4 (8.8, 20.1) |
| >50 y | 144 | 84.1 | 1.7 (1.4, 2.0) | 8.6 (6.7, 10.8) |
| HCT diagnosis category | ||||
| Nonmalignant disorder | 34 | 13.2 | 2.6 (1.8, 3.7) | 8.0 (5.2, 11.5) |
| Hematologic/lymphoid malignancy | 547 | 191.8 | 2.9 (2.6, 3.1) | 8.7 (6.3, 11.7) |
| Preparative regimen | ||||
| Chemotherapy only | 144 | 75.9 | 1.9 (1.6, 2.3) | 6.9 (5.9, 8.03) |
| Low-dose TBI 200-450 cGy | 63 | 31.1 | 2.0 (1.6, 2.6) | 4.2 (2.7, 5.9) |
| Single-dose TBI 600-1000 cGy | 37 | 4.7 | 7.8 (5.5, 11.2) | 8.6 (6.8, 10.7) |
| Fractionated TBI 600-1200 cGy | 183 | 56.4 | 3.3 (2.8, 3.8) | 7.6 (5.5, 10.1) |
| Fractionated TBI 1320-1400 cGy | 68 | 22 | 3.1 (2.4, 4.0) | 7.6 (5.1, 10.5) |
| Fractionated TBI 1440-1750 cGy | 81 | 14.2 | 5.7 (4.5, 7.3) | 4.9 (3.2, 6.8) |
| Stem cell source | ||||
| BM | 431 | 143.6 | 3.0 (2.7, 3.3) | 10.6 (7.7, 14.1) |
| PBSC/BM+PBSC | 144 | 60.7 | 2.4 (2.0, 2.8) | 11.6 (4.1, 29.1) |
| Cord | 6 | 0.7 | 8.7 (3.7, 20.4) | 3.2 (1.6, 55) |
| GVHD status* | ||||
| None | 91 | 34.7 | 2.6 (2.1, 3.3) | 5.1 (3.4, 7.2) |
| Acute only | 100 | 32.4 | 31 (25, 3.8) | 7.6 (5.4, 10.2) |
| Chronic (± acute) | 353 | 131.6 | 3.0 (2.4, 3.0) | 8.2 (6.8, 9.7) |
| Follow-up time after first allogeneic HCT,*y | ||||
| ≤10 | 396 | 142.1 | 2.8 (2.5, 3.1) | 6.8 (5.7, 8.0) |
| >10-20 | 119 | 44.3 | 2.7 (2.2, 3.3) | 8.0 (5.7, 10.7) |
| >20-30 | 59 | 16.5 | 3.6 (2.7, 4.7) | 13.5 (9.0, 19.44) |
| >30 | 7 | 2 | 3.4 (1.7, 7.2) | 13.7 (3.6, 34.7) |
| Current age,*y | ||||
| ≤20 | 37 | 1.2 | 30.9 (22.6, 42.4) | 5.4 (3.9, 7.5) |
| >20-50 | 239 | 53 | 4.5 (3.9, 5.2) | 6.4 (5.3, 7.5) |
| >50 | 305 | 150.8 | 2.0 (1.8, 2.3) | 10.9 (8.5, 13.7) |
Time-dependent factors.