Hematologic features of HVLPD patients
| Patient . | Race/sex . | CD4 . | CD8 . | CD20 . | NK . | γ-δ T cells . | Ki67/CD3 cells . | T4/T8 ratio . | IgG . | Clonality . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | WM | 990 | 466 | 148 | 115 | 138 | 15 | 2.28 | 1038 | T-cell clone in blood and bone marrow |
| 2 | WF | 709 | 404 | 195* | 30 | ND | ND | ND | 864 | Polyclonal |
| 3 | WM | 619 | 652 | 367 | 357 | 939 | 44 | 1.28 | 827 | Indeterminate for T-cell clone in blood and bone marrow |
| 4 | WM | 466 | 304 | 334 | 564 | 109† | 10 | 1.53 | 866 | Indeterminate for T-cell clone |
| 5 | WM | 813 | 543 | 226* | 118 | ND | ND | ND | 1360 | T-cell clone in ileum and in blood |
| 6 | WF | 446 | 188 | 128 | 102 | 282 | 22 | 1.93 | 982 | Indeterminate for T-cell clone in blood |
| 7 | WF | 828 | 540 | 343 | 197 | 151 | 32 | 1.58 | 858 | Indeterminate for T-cell clone in blood; marrow polyclonal |
| 8 | WF | 676 | 289 | 220 | 120 | 131 | 32 | 2.34 | 1107 | Indeterminate for T-cell clone |
| 9 | WF | 1048 | 398 | 210 | 164 | 118 | 46 | 2.64 | 985 | Polyclonal |
| 10 | WF | 863 | 432 | 366 | 160 | 357 | ND | 2.00 | 910 | T-cell clone in blood |
| 11 | HM | 471 | 1166 | 160* | 77 | ND | ND | ND | 1910 | T-cell clone in skin, blood, and bone marrow |
| 12 | HM | 1395 | 462 | 186 | 117 | 111 | 18 | 3.06 | 1178 | T-cell clone in blood |
| 13 | AF | 122 | 1918 | 2 | 6 | ND | ND | 0.06 | 885 | T-cell clone in skin, blood, bone marrow, CSF, and BAL |
| 14 | AM | 203 | 1121 | 15 | 76 | 50 | 20 | 0.18 | 1760 | T-cell clone in blood |
| 15 | HF | 593 | 414 | 264 | 52 | 1326† | 114 | 1.43 | 1234 | Indeterminate for T-cell clone |
| 16 | HM | 443 | 890 | 341 | 211 | 1899 | 327 | 0.50 | 1557 | T-cell clone |
| Patient . | Race/sex . | CD4 . | CD8 . | CD20 . | NK . | γ-δ T cells . | Ki67/CD3 cells . | T4/T8 ratio . | IgG . | Clonality . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | WM | 990 | 466 | 148 | 115 | 138 | 15 | 2.28 | 1038 | T-cell clone in blood and bone marrow |
| 2 | WF | 709 | 404 | 195* | 30 | ND | ND | ND | 864 | Polyclonal |
| 3 | WM | 619 | 652 | 367 | 357 | 939 | 44 | 1.28 | 827 | Indeterminate for T-cell clone in blood and bone marrow |
| 4 | WM | 466 | 304 | 334 | 564 | 109† | 10 | 1.53 | 866 | Indeterminate for T-cell clone |
| 5 | WM | 813 | 543 | 226* | 118 | ND | ND | ND | 1360 | T-cell clone in ileum and in blood |
| 6 | WF | 446 | 188 | 128 | 102 | 282 | 22 | 1.93 | 982 | Indeterminate for T-cell clone in blood |
| 7 | WF | 828 | 540 | 343 | 197 | 151 | 32 | 1.58 | 858 | Indeterminate for T-cell clone in blood; marrow polyclonal |
| 8 | WF | 676 | 289 | 220 | 120 | 131 | 32 | 2.34 | 1107 | Indeterminate for T-cell clone |
| 9 | WF | 1048 | 398 | 210 | 164 | 118 | 46 | 2.64 | 985 | Polyclonal |
| 10 | WF | 863 | 432 | 366 | 160 | 357 | ND | 2.00 | 910 | T-cell clone in blood |
| 11 | HM | 471 | 1166 | 160* | 77 | ND | ND | ND | 1910 | T-cell clone in skin, blood, and bone marrow |
| 12 | HM | 1395 | 462 | 186 | 117 | 111 | 18 | 3.06 | 1178 | T-cell clone in blood |
| 13 | AF | 122 | 1918 | 2 | 6 | ND | ND | 0.06 | 885 | T-cell clone in skin, blood, bone marrow, CSF, and BAL |
| 14 | AM | 203 | 1121 | 15 | 76 | 50 | 20 | 0.18 | 1760 | T-cell clone in blood |
| 15 | HF | 593 | 414 | 264 | 52 | 1326† | 114 | 1.43 | 1234 | Indeterminate for T-cell clone |
| 16 | HM | 443 | 890 | 341 | 211 | 1899 | 327 | 0.50 | 1557 | T-cell clone |
Values in bold are below the limit of normal. Underlined values are above the upper limit of normal.
BAL, bronchoalveolar lavage; ND, not done.
CD19 cells measured.
γ-δ T cells were also present in the skin biopsy specimen. Normal values are as follows: CD4 cells, 359 to 1565; CD8 cells, 178 to 853; CD19 cells, 81 to 493; CD20 cells, 59 to 329; NK cells, 126 to 729, γ-δ T cells, 8 to 261, Ki67/CD3 cells, 9 to 18; T4/T8 ratio, 1.11 to 5.17; and IgG, 698 to 1560 mg/dL.