Top 12 genes up- or downregulated in HVLPD skin compared with unaffected skin in patient 1 based on RNA-sequencing gene expression analysis
| Gene . | Protein . | Log2 fold increase or decrease (HVLPD vs unaffected skin) . |
|---|---|---|
| Upregulated | ||
| CXCL11 | I-TAC | 15.91 |
| DCD | Dermcidin | 14.99 |
| SCGB2A2 | Secretoglobin | 14.82 |
| CXCL10 | IP-10 | 13.31 |
| IFNG | IFN-γ | 13.30 |
| SCGB1D2 | Secretoglobin family 1D member 2 | 13.05 |
| SERPINB4 | Serpin family B member 4 | 12.79 |
| PIP | Prolactin-induced protein | 12.75 |
| CXCL9 | MIG | 12.51 |
| IDO1 | Indoleamine 2,3 dioxygenase 1 | 12.21 |
| PRR4 | Proline-rich 4 | 11.76 |
| CCL4 | MIP1β | 11.71 |
| Downregulated | ||
| KRT79 | Keratin 79 | 11.84 |
| PM20D1 | Peptidase M20 domain containing 1 | 10.88 |
| AADACL3 | Arylacetamide deacetylase-like 3 | 10.76 |
| DGAT2L6 | Diacylglycerol O-acyltransferase 2 like 6 | 10.16 |
| AWAT2 | Acyl-CoA wax alcohol acyltransferase | 9.51 |
| SEC14L6 | SEC14-like lipid binding | 9.42 |
| FABP7 | Fatty acid binding protein 7 | 9.05 |
| CCL14 | CC-1 | 8.65 |
| THRSP | Thyroid hormone responsive | 8.59 |
| HAO2 | Hydroxyacid oxidase 2 | 8.46 |
| TMEM56 | Transmembrane protein 56 | 8.01 |
| UGT2A1 | UDP glucuronosyltransferase family 2 member A1 complex locus | 7.96 |
| Gene . | Protein . | Log2 fold increase or decrease (HVLPD vs unaffected skin) . |
|---|---|---|
| Upregulated | ||
| CXCL11 | I-TAC | 15.91 |
| DCD | Dermcidin | 14.99 |
| SCGB2A2 | Secretoglobin | 14.82 |
| CXCL10 | IP-10 | 13.31 |
| IFNG | IFN-γ | 13.30 |
| SCGB1D2 | Secretoglobin family 1D member 2 | 13.05 |
| SERPINB4 | Serpin family B member 4 | 12.79 |
| PIP | Prolactin-induced protein | 12.75 |
| CXCL9 | MIG | 12.51 |
| IDO1 | Indoleamine 2,3 dioxygenase 1 | 12.21 |
| PRR4 | Proline-rich 4 | 11.76 |
| CCL4 | MIP1β | 11.71 |
| Downregulated | ||
| KRT79 | Keratin 79 | 11.84 |
| PM20D1 | Peptidase M20 domain containing 1 | 10.88 |
| AADACL3 | Arylacetamide deacetylase-like 3 | 10.76 |
| DGAT2L6 | Diacylglycerol O-acyltransferase 2 like 6 | 10.16 |
| AWAT2 | Acyl-CoA wax alcohol acyltransferase | 9.51 |
| SEC14L6 | SEC14-like lipid binding | 9.42 |
| FABP7 | Fatty acid binding protein 7 | 9.05 |
| CCL14 | CC-1 | 8.65 |
| THRSP | Thyroid hormone responsive | 8.59 |
| HAO2 | Hydroxyacid oxidase 2 | 8.46 |
| TMEM56 | Transmembrane protein 56 | 8.01 |
| UGT2A1 | UDP glucuronosyltransferase family 2 member A1 complex locus | 7.96 |
CoA, coenzyme A; UDP, uridine diphosphate.