Multivariable risk factor analysis for cGVHD and L-aGVHD development in children
| Variable . | cGVHD . | L-aGVHD . | ||
|---|---|---|---|---|
| OR (CI) . | P . | OR (CI) . | P . | |
| Maximal previous aGVHD grade | ||||
| Grade 2-4 | 5.479 (2.304-13.025) | .0001 | 6.346 (2.919-13.794) | <.0001 |
| Grade 0-1 | Reference | Reference | ||
| Stem cell source | ||||
| PBSC | 4.110 (1.481-11.083) | .0064 | 3.132 (1.138-8.622) | .0271 |
| Cord blood | 2.308 (0.481-11.083) | .2962 | 1.849 (0.545-6.272) | .3237 |
| Bone marrow | Reference | Reference | ||
| Age of recipient at time of transplant, y | ||||
| ≥12 | 3.073 (1.244-7.590) | .0150 | 0.598 (0.277-1.292) | .1906 |
| <12 | Reference | Reference | ||
| GVHD prophylaxis | ||||
| Other | 0.241 (0.078-0.743) | .0132 | 0.647 (0.269-3.687) | .3321 |
| CNI + MTx | Reference | Reference | ||
| Variable . | cGVHD . | L-aGVHD . | ||
|---|---|---|---|---|
| OR (CI) . | P . | OR (CI) . | P . | |
| Maximal previous aGVHD grade | ||||
| Grade 2-4 | 5.479 (2.304-13.025) | .0001 | 6.346 (2.919-13.794) | <.0001 |
| Grade 0-1 | Reference | Reference | ||
| Stem cell source | ||||
| PBSC | 4.110 (1.481-11.083) | .0064 | 3.132 (1.138-8.622) | .0271 |
| Cord blood | 2.308 (0.481-11.083) | .2962 | 1.849 (0.545-6.272) | .3237 |
| Bone marrow | Reference | Reference | ||
| Age of recipient at time of transplant, y | ||||
| ≥12 | 3.073 (1.244-7.590) | .0150 | 0.598 (0.277-1.292) | .1906 |
| <12 | Reference | Reference | ||
| GVHD prophylaxis | ||||
| Other | 0.241 (0.078-0.743) | .0132 | 0.647 (0.269-3.687) | .3321 |
| CNI + MTx | Reference | Reference | ||
CI, confidence interval; CNI, calcineurin inhibitor; MTx, methotrexate.