Table 1.

Patient characteristics

VariablesNumber of patients
Median age, y 61 (range, 41-68) 
Male:female 2:1 
ECOG performance status >1 
High lactic dehydrogenase serum level 
High CSF protein concentration* 
Involvement of deep areas 
IELSG risk score  
 Low 
 Intermediate 
 High 
Intraocular disease 
Meningeal dissemination 
Previous lines  
 Previous lines ≥2 
 Previous ASCT 
 Previous WBRT 
 Both ASCT + WBRT 
Refractory to previous lines 
VariablesNumber of patients
Median age, y 61 (range, 41-68) 
Male:female 2:1 
ECOG performance status >1 
High lactic dehydrogenase serum level 
High CSF protein concentration* 
Involvement of deep areas 
IELSG risk score  
 Low 
 Intermediate 
 High 
Intraocular disease 
Meningeal dissemination 
Previous lines  
 Previous lines ≥2 
 Previous ASCT 
 Previous WBRT 
 Both ASCT + WBRT 
Refractory to previous lines 

ECOG, Eastern Cooperative Oncology Group; IELSG, International Extranodal Lymphoma Study Group.

*

Lumbar puncture was contraindicated in 3 patients; CSF protein concentration was considered as unfavorable feature in IELSG risk score in these patients.

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