Pregnancy outcomes in patients with partial quantitative VWD (low VWF and type 1 VWD)
| Study . | Total no. women with VWD (deliveries) . | No. with type 1 VWD or low VWF . | PPH rates in women with quantitative VWD (unless specified), % . | Baseline prepregnant plasma VWF levels, median (range), IU/dL . |
|---|---|---|---|---|
| Ramsahoye et al56 | 13 (24) | n = 7, type 1, 13 deliveries | Primary, 0; secondary, 23.1 | VWF:Ag, 8 (5-40); VWF:Act, 7 (3.1-26) |
| Kadir et al57 | 31 | n = 27, type 1, 54 deliveries | Primary, 18.5; secondary, 20 | VWF:Ag, 43 (0.5-72); VWF:Act, 40 (0.5-70) |
| Ragni et al65 | 38 | Type 1, n = 38 | Overall PPH, 13.1 | Mean VWF:Ag, 62 |
| Kouides et al66 | 48 | Type 1 VWD, n = 25 | Primary, 42 (in all VWD) | No baseline levels provided |
| Kirtava et al67 | 102 | All VWD, subtype unspecified | Overall PPH, 59 | No baseline levels provided |
| James and Jamison58 | 4067 | All VWD, subtype unspecified | Overall PPH, 6 | No baseline levels provided |
| De Wee et al68 | 314 (691) | Type 1, n = 242 | Overall PPH, 37 | Not provided; all patients <30 IU/dL |
| Chee et al69 | 33 (62) | Type 1, n = 24 | Primary, 19.4 (in all VWD) | Not provided; included those <50 IU/dL |
| Stoof et al59 | 154 (185) | Type 1, n = 49; 56 deliveries | Primary, 37 | Median VWF:Act, 50 |
| James et al52 | 32 (35) | Type 1, no treatment required, n = 17 | No PPH reported | Mean VWF:Ag, 57; Mean VWF:RCo, 42 |
| Hawke et al62 | 33 (62) | Type 1, 39 deliveries | Primary PPH, 18; secondary PPH, 29 (in all VWD) | No baseline levels provided |
| Govorov et al70 | 34 (59) | Type 1, n = 21; 39 deliveries | Primary, 46.2; secondary, 10.3 | No baseline levels provided |
| Sood et al55 | 11 (11) | Type 1, n = 11 | Primary, 9 (1/11); secondary, 9 (1/11) | Mean VWF:Ag, 41.1; Mean VWF:Act, 34.4 |
| Lavin et al21 | 74 (181) | Low VWF, n = 74; 181 deliveries | Primary, 48.6; secondary, 33.7 | VWF:Ag, 49 (33-72); VWF:RCo, 39 (30-54) |
| Study . | Total no. women with VWD (deliveries) . | No. with type 1 VWD or low VWF . | PPH rates in women with quantitative VWD (unless specified), % . | Baseline prepregnant plasma VWF levels, median (range), IU/dL . |
|---|---|---|---|---|
| Ramsahoye et al56 | 13 (24) | n = 7, type 1, 13 deliveries | Primary, 0; secondary, 23.1 | VWF:Ag, 8 (5-40); VWF:Act, 7 (3.1-26) |
| Kadir et al57 | 31 | n = 27, type 1, 54 deliveries | Primary, 18.5; secondary, 20 | VWF:Ag, 43 (0.5-72); VWF:Act, 40 (0.5-70) |
| Ragni et al65 | 38 | Type 1, n = 38 | Overall PPH, 13.1 | Mean VWF:Ag, 62 |
| Kouides et al66 | 48 | Type 1 VWD, n = 25 | Primary, 42 (in all VWD) | No baseline levels provided |
| Kirtava et al67 | 102 | All VWD, subtype unspecified | Overall PPH, 59 | No baseline levels provided |
| James and Jamison58 | 4067 | All VWD, subtype unspecified | Overall PPH, 6 | No baseline levels provided |
| De Wee et al68 | 314 (691) | Type 1, n = 242 | Overall PPH, 37 | Not provided; all patients <30 IU/dL |
| Chee et al69 | 33 (62) | Type 1, n = 24 | Primary, 19.4 (in all VWD) | Not provided; included those <50 IU/dL |
| Stoof et al59 | 154 (185) | Type 1, n = 49; 56 deliveries | Primary, 37 | Median VWF:Act, 50 |
| James et al52 | 32 (35) | Type 1, no treatment required, n = 17 | No PPH reported | Mean VWF:Ag, 57; Mean VWF:RCo, 42 |
| Hawke et al62 | 33 (62) | Type 1, 39 deliveries | Primary PPH, 18; secondary PPH, 29 (in all VWD) | No baseline levels provided |
| Govorov et al70 | 34 (59) | Type 1, n = 21; 39 deliveries | Primary, 46.2; secondary, 10.3 | No baseline levels provided |
| Sood et al55 | 11 (11) | Type 1, n = 11 | Primary, 9 (1/11); secondary, 9 (1/11) | Mean VWF:Ag, 41.1; Mean VWF:Act, 34.4 |
| Lavin et al21 | 74 (181) | Low VWF, n = 74; 181 deliveries | Primary, 48.6; secondary, 33.7 | VWF:Ag, 49 (33-72); VWF:RCo, 39 (30-54) |