Cytotoxicity of onconase or LL2-onconase on human cell lines
| Cell line . | LL2-onconase . | Onconase (−)monensin . | |
|---|---|---|---|
| (−)monensin . | (+)monensin . | ||
| IC50(pM) . | IC50 (pM) . | ||
| Daudi | 20 | 1.5 | 400 000 |
| Ramos | 1000 | 50 | >200 000 |
| Raji | 200 | ND* | >200 000 |
| RL | 1200 | ND | ND |
| HUT-102 | >100 000 | ND | 50 000 |
| Cell line . | LL2-onconase . | Onconase (−)monensin . | |
|---|---|---|---|
| (−)monensin . | (+)monensin . | ||
| IC50(pM) . | IC50 (pM) . | ||
| Daudi | 20 | 1.5 | 400 000 |
| Ramos | 1000 | 50 | >200 000 |
| Raji | 200 | ND* | >200 000 |
| RL | 1200 | ND | ND |
| HUT-102 | >100 000 | ND | 50 000 |
The concentration necessary to inhibit protein synthesis by 50% (IC50) is shown. LL2 antibody did not inhibit protein synthesis at the highest concentration tested (20 000 pM).
ND, not determined.