Toxicity in mice of onconase and LL2-onconase
| Drug . | Schedule . | Survivors/total . |
|---|---|---|
| Onconase | 1 mg ip × 1 | 0/4 |
| 25 μg iv QD × 5 | 2/2 | |
| 50 μg iv QD × 5 | 2/2 | |
| 100 μg iv QD × 5 | 0/2 | |
| 200 μg iv QD × 5 | 0/2 | |
| 2 × 50 μg ip QD × 5 | 1/2 | |
| 2 × 75 μg ip QD × 5 | 0/4 | |
| LL2-onconase | 300 μg iv QD × 5 | 2/2 |
| 2 × 300 μg ip QD × 5 | 2/2 | |
| 4 × 300 μg ip QD × 5 | 2/2 | |
| 4 × 400 μg ip QD × 5 | 0/3 |
| Drug . | Schedule . | Survivors/total . |
|---|---|---|
| Onconase | 1 mg ip × 1 | 0/4 |
| 25 μg iv QD × 5 | 2/2 | |
| 50 μg iv QD × 5 | 2/2 | |
| 100 μg iv QD × 5 | 0/2 | |
| 200 μg iv QD × 5 | 0/2 | |
| 2 × 50 μg ip QD × 5 | 1/2 | |
| 2 × 75 μg ip QD × 5 | 0/4 | |
| LL2-onconase | 300 μg iv QD × 5 | 2/2 |
| 2 × 300 μg ip QD × 5 | 2/2 | |
| 4 × 300 μg ip QD × 5 | 2/2 | |
| 4 × 400 μg ip QD × 5 | 0/3 |
Proteins diluted in phosphate-buffered saline (PBS) were administered once, twice, or 4 times daily (QD) for 5 consecutive days. Mice receiving more than one injection daily were compared with mice that received injections of PBS only. Mice were observed for signs of toxicity and weighed daily for several weeks after the last administration of drug.
ip indicates intraperitoneally; iv, intravenously.