Red cell indices of knockout mice
| No. . | . | N . | βS % . | αH % . | γ % 2 wk . | γ % >9 wk . | β/α ratio . | MCH pg/cell . | MCV fl . | MCHC g/dL* . | Retics % Sysmex . | Hct . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | C57BL CONTROL | 20 | — | — | — | — | 0.93 | 14.5 ± 1.0 | 45.4 ± 0.9 | 33 ± 1.2 | 2.2 ± 0.5 | 48 ± 1 |
| 2 | C57BL Hbbth-1//Hbbth-1 | |||||||||||
| THAL | 6 | — | — | — | — | 0.79, 0.75†-0.78‡ | 12.7 ± 0.5 | 39.1 ± 1.9 | 24.9 ± 1.3 | 24.6 ± 3.3 | 32.3 ± 1.6 | |
| 3 | α2βSγ(F1352)Hba0//Hba0Hbb0//Hbb0 | |||||||||||
| NY1KO γL | 4 | 97 | 100 | 4 | <3 | 0.902-155 | 14.2 ± 1.12-155 | 57.3 ± 1.4 | 20.8 ± 1.9 | 63.2 ± 11.82-164 | 22.4 ± 1.32-a | |
| 4 | α2βSγ(G203)Hba0//Hba0Hbb0//Hbb0 | |||||||||||
| NY1KO γM | 10 | 80 | 100 | 7 | 20 | 0.932-155 | 13.7 ± 0.8# | 53.5 ± 1.9 | 24 ± 1.8 | 30.1 ± 9.62-154 | 34.0 ± 4.62-b,2-c | |
| 5 | α2βSγ(G100)Hba0//Hba0Hbb0//Hbb0 | |||||||||||
| NY1KO γH | 20 | 60 | 100 | 27 | 40 | 0.952-155 | 14.4 ± 0.52-155 | 49.3 ± 1.6 | 31 ± 1.9 | 12.9 ± 2.72-161 | 41.1 ± 4.02-d | |
| 6 | α1GγAγδβSHba0//Hba0Hbb0//Hbb0 | |||||||||||
| BERK | 20 | >99 | 100 | <1 | <1 | 0.82, 0.792-153 | 9.3 ± 1.0 | 42.1 ± 1.8 | 18.5 ± 1.4 | 36.5 ± 8.02-154 | 28.7 ± 4.02-e | |
| 7 | α1GγAγδβSγ(G203)Hba0//Hba0Hbb0//Hbb0 | |||||||||||
| BERK γM | 5 | 79 | 100 | 15 | 21 | 0.892-155 | 10.8 ± 1.52-160 | 43.6 ± 1.8 | 22.9 ± 1.8 | 37.2 ± 5.82-154 | 41.6 ± 4.02-f |
| No. . | . | N . | βS % . | αH % . | γ % 2 wk . | γ % >9 wk . | β/α ratio . | MCH pg/cell . | MCV fl . | MCHC g/dL* . | Retics % Sysmex . | Hct . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | C57BL CONTROL | 20 | — | — | — | — | 0.93 | 14.5 ± 1.0 | 45.4 ± 0.9 | 33 ± 1.2 | 2.2 ± 0.5 | 48 ± 1 |
| 2 | C57BL Hbbth-1//Hbbth-1 | |||||||||||
| THAL | 6 | — | — | — | — | 0.79, 0.75†-0.78‡ | 12.7 ± 0.5 | 39.1 ± 1.9 | 24.9 ± 1.3 | 24.6 ± 3.3 | 32.3 ± 1.6 | |
| 3 | α2βSγ(F1352)Hba0//Hba0Hbb0//Hbb0 | |||||||||||
| NY1KO γL | 4 | 97 | 100 | 4 | <3 | 0.902-155 | 14.2 ± 1.12-155 | 57.3 ± 1.4 | 20.8 ± 1.9 | 63.2 ± 11.82-164 | 22.4 ± 1.32-a | |
| 4 | α2βSγ(G203)Hba0//Hba0Hbb0//Hbb0 | |||||||||||
| NY1KO γM | 10 | 80 | 100 | 7 | 20 | 0.932-155 | 13.7 ± 0.8# | 53.5 ± 1.9 | 24 ± 1.8 | 30.1 ± 9.62-154 | 34.0 ± 4.62-b,2-c | |
| 5 | α2βSγ(G100)Hba0//Hba0Hbb0//Hbb0 | |||||||||||
| NY1KO γH | 20 | 60 | 100 | 27 | 40 | 0.952-155 | 14.4 ± 0.52-155 | 49.3 ± 1.6 | 31 ± 1.9 | 12.9 ± 2.72-161 | 41.1 ± 4.02-d | |
| 6 | α1GγAγδβSHba0//Hba0Hbb0//Hbb0 | |||||||||||
| BERK | 20 | >99 | 100 | <1 | <1 | 0.82, 0.792-153 | 9.3 ± 1.0 | 42.1 ± 1.8 | 18.5 ± 1.4 | 36.5 ± 8.02-154 | 28.7 ± 4.02-e | |
| 7 | α1GγAγδβSγ(G203)Hba0//Hba0Hbb0//Hbb0 | |||||||||||
| BERK γM | 5 | 79 | 100 | 15 | 21 | 0.892-155 | 10.8 ± 1.52-160 | 43.6 ± 1.8 | 22.9 ± 1.8 | 37.2 ± 5.82-154 | 41.6 ± 4.02-f |
Mean ± SD. The statistics were calculated using the program StatGraphics.
Determined by hand-spun hematocrit and Drabkin hemoglobin, note that the very high reticulocyte counts will result in abnormally low MCHCs.
Skow et al.26
Sauvage et al.27
Pàszty et al.13
Not statistically different from C57BL.
Not statistically different versus each other in same column.
#4 versus 5 P < .02.
6 versus 7 P < .05.
3 versus 4 P < .01.
4 versus 5 P < .002.
3 versus 4 P < .01.
4 versus 5 P < .01.
4 versus 6 P < .05.
5 versus 7 not statistically different.
6 versus 7 P < .001.
C57BL versus 5 or 7 P < .02.