Organ weights as percentage of body weight for mice expressing exclusively human hemoglobins
| Mouse . | γ % >9 wk . | Age (d) . | Liver . | Spleen . | Kidney single . | Heart . |
|---|---|---|---|---|---|---|
| C57BL | — | 135 ± 30 | 4.8 ± 0.8 | 0.26 ± 0.04 | 0.57 ± 0.03 | 0.48 ± 0.09 |
| NY1KOγL | <3 | 43 ± 8 | 7.4 ± 0.3 | 3.7 ± 0.4 | 0.8 ± 0.02 | 0.78 ± 0.04 |
| NY1KOγM | 20 | 116 ± 51 | 7.0 ± 2.1 | 5.3 ± 0.6 | 1.3 ± 0.4 | 0.79 ± 0.04 |
| NY1KOγH | 40 | 124 ± 26 | 6.4 ± 0.5 | 1.3 ± 0.3 | 0.9 ± 0.2 | 0.67 ± 0.12 |
| BERK | <1 | 94 ± 35 | 8.2 ± 0.8 | 8.6 ± 1.3 | 1.0 ± 0.2 | 0.87 ± 0.15 |
| BERKγM | 21 | 124 ± 41 | 5.8 ± 0.8 | 7.5 ± 1.5 | 1.0 ± 0.2 | 0.9 ± 0.06 |
| Mouse . | γ % >9 wk . | Age (d) . | Liver . | Spleen . | Kidney single . | Heart . |
|---|---|---|---|---|---|---|
| C57BL | — | 135 ± 30 | 4.8 ± 0.8 | 0.26 ± 0.04 | 0.57 ± 0.03 | 0.48 ± 0.09 |
| NY1KOγL | <3 | 43 ± 8 | 7.4 ± 0.3 | 3.7 ± 0.4 | 0.8 ± 0.02 | 0.78 ± 0.04 |
| NY1KOγM | 20 | 116 ± 51 | 7.0 ± 2.1 | 5.3 ± 0.6 | 1.3 ± 0.4 | 0.79 ± 0.04 |
| NY1KOγH | 40 | 124 ± 26 | 6.4 ± 0.5 | 1.3 ± 0.3 | 0.9 ± 0.2 | 0.67 ± 0.12 |
| BERK | <1 | 94 ± 35 | 8.2 ± 0.8 | 8.6 ± 1.3 | 1.0 ± 0.2 | 0.87 ± 0.15 |
| BERKγM | 21 | 124 ± 41 | 5.8 ± 0.8 | 7.5 ± 1.5 | 1.0 ± 0.2 | 0.9 ± 0.06 |
All values are mean ± standard deviation. For spleen and kidney, the organ weights of all transgenic mice are statistically greater than those of C57BL; but the differences between different types of transgenic mice are, for the most part, not statistically significant.