Autocrine IL-6 production and resistance of myeloma cells to spontaneous and dexamethasone-induced apoptosis
| Myeloma cell clone/line . | Apoptotic cells (%) . | |||
|---|---|---|---|---|
| Spontaneous . | With dexamethasone . | |||
| Without IL-6 . | With IL-6 . | Without IL-6 . | With IL-6 . | |
| MCC-1 | 25.8 | 9.4 | 45.9 | 13.2 |
| MCC-2 | 5.4 | 3.6 | 7.3 | 6.9 |
| MCC-3 | 8.6 | 5.8 | 14.7 | 10.3 |
| MCC-4 | 47.3 | 8.2 | 85.6 | 12.7 |
| MCC-5 | 7.3 | 5.4 | 13.1 | 15.9 |
| MCC-6 | 35.4 | 5.9 | 68.4 | 8.5 |
| U-266 | 15.4 | 6.7 | 58.6 | 4.7 |
| IM-9 | 4.1 | 3.9 | 4.5 | 5.1 |
| Myeloma cell clone/line . | Apoptotic cells (%) . | |||
|---|---|---|---|---|
| Spontaneous . | With dexamethasone . | |||
| Without IL-6 . | With IL-6 . | Without IL-6 . | With IL-6 . | |
| MCC-1 | 25.8 | 9.4 | 45.9 | 13.2 |
| MCC-2 | 5.4 | 3.6 | 7.3 | 6.9 |
| MCC-3 | 8.6 | 5.8 | 14.7 | 10.3 |
| MCC-4 | 47.3 | 8.2 | 85.6 | 12.7 |
| MCC-5 | 7.3 | 5.4 | 13.1 | 15.9 |
| MCC-6 | 35.4 | 5.9 | 68.4 | 8.5 |
| U-266 | 15.4 | 6.7 | 58.6 | 4.7 |
| IM-9 | 4.1 | 3.9 | 4.5 | 5.1 |