Table 4.

Multivariate analysis of prognostic factor

Univariate analysisMultivariate analysis
HR95% CIPHR95% CIP
RFS       
 WBC count <20 × 109/L 0.415 0.216-0.800 <.001 1.113 0.474-2.614 .805 
 Age 1.017 0.998-1.036 .077    
 Not poor cytogenetic prognosis 1.008 0.245-4.148 .991    
 AR <0.5 0.460 0.255-0.830 .010 0.578 0.284-1.178 .135 
 Presence of NPM1 mut 1.536 0.903-2.614 .114    
 Allo-HSCT at any time 0.641 0.343-1.197 .163 NA NA NA 
 Allo-HSCT at CR1 0.083 0.030-0.234 <.001 0.066 0.020-0.218 <.001 
OS       
 WBC count <20 × 109/L 0.544 0.321-0.924 .024 0.754 0.376-1.513 .427 
 Age 1.039 1.023-1.055 <.001 1.033 1.016-1.051 <.001 
 Not poor cytogenetic prognosis 1.037 0.379-2.838 .944    
 AR <0.5 0.555 0.343-0.898 .017 0.747 0.435-1.286 .293 
 Presence of NPM1 mut 1.313 0.846-2.038 .225    
 Allo-HSCT at any stage 0.248 0.150-0.409 <.001 NA NA NA 
 Allo-HSCT in CR1 0.113 0.045-0.281 <.001 0.092 0.028-0.302 <.001 
Univariate analysisMultivariate analysis
HR95% CIPHR95% CIP
RFS       
 WBC count <20 × 109/L 0.415 0.216-0.800 <.001 1.113 0.474-2.614 .805 
 Age 1.017 0.998-1.036 .077    
 Not poor cytogenetic prognosis 1.008 0.245-4.148 .991    
 AR <0.5 0.460 0.255-0.830 .010 0.578 0.284-1.178 .135 
 Presence of NPM1 mut 1.536 0.903-2.614 .114    
 Allo-HSCT at any time 0.641 0.343-1.197 .163 NA NA NA 
 Allo-HSCT at CR1 0.083 0.030-0.234 <.001 0.066 0.020-0.218 <.001 
OS       
 WBC count <20 × 109/L 0.544 0.321-0.924 .024 0.754 0.376-1.513 .427 
 Age 1.039 1.023-1.055 <.001 1.033 1.016-1.051 <.001 
 Not poor cytogenetic prognosis 1.037 0.379-2.838 .944    
 AR <0.5 0.555 0.343-0.898 .017 0.747 0.435-1.286 .293 
 Presence of NPM1 mut 1.313 0.846-2.038 .225    
 Allo-HSCT at any stage 0.248 0.150-0.409 <.001 NA NA NA 
 Allo-HSCT in CR1 0.113 0.045-0.281 <.001 0.092 0.028-0.302 <.001 

HR, hazard ratio; NA, not available.

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