Table 1.

Questions included in these guidelines

1. Should antithrombotic therapy (UFH or LMWH) vs no antithrombotics be used for pregnant women with acute VTE? 
2. Should anticoagulant intervention vs no anticoagulant intervention be used for pregnant women with proven superficial vein thrombosis? 
3. Should LMWH twice per day vs LMWH once per day be used for pregnant women with acute VTE? 
4. Should routine anti-FXa monitoring to guide dose adjustment vs no monitoring be used in pregnant women receiving therapeutic-dose LMWH for the treatment of VTE? 
5. Should catheter-directed thrombolytic therapy vs no catheter-directed thrombolytic therapy be used in addition to anticoagulant therapy in pregnant women with acute lower-extremity DVT? 
6. Should thrombolytic therapy vs no thrombolytic therapy be used in addition to anticoagulant therapy in pregnant women with acute hemodynamically significant pulmonary embolism or pulmonary embolism with significant right ventricular dysfunction? 
7. Should outpatient therapy vs hospital admission be used in the initial treatment of pregnant patients with low-risk acute VTE? 
8. Should scheduled delivery with discontinuation of LMWH vs cessation of LMWH with spontaneous onset of labor be used for pregnant women receiving therapeutic-dose LMWH? 
9. Should scheduled delivery with prior discontinuation of prophylactic-dose LMWH vs cessation of prophylactic LMWH at the onset of spontaneous labor be used for pregnant women receiving prophylactic-dose LMWH? 
10. Should one particular anticoagulant vs any other anticoagulant be used for breastfeeding women who have an indication for anticoagulation? 
11. Should anticoagulant prophylaxis vs no anticoagulant prophylaxis be used for prevention of VTE in women undergoing assisted reproduction? 
12. Should antepartum anticoagulant prophylaxis vs no antepartum anticoagulant prophylaxis be used for pregnant women with prior VTE? 
13. Should postpartum anticoagulant prophylaxis vs no postpartum anticoagulant prophylaxis be used for pregnant women with prior VTE? 
14. Should antepartum anticoagulant prophylaxis vs no antepartum anticoagulant prophylaxis be used for pregnant women with thrombophilia to prevent a first venous thromboembolic event? 
15. Should postpartum anticoagulant prophylaxis vs no postpartum anticoagulant prophylaxis be used for pregnant women with thrombophilia to prevent a first venous thromboembolic event? 
16. Should anticoagulant prophylaxis vs no anticoagulant prophylaxis be used for pregnant women with clinical risk factors for VTE? 
17. Should intermediate-dose LMWH prophylaxis vs standard-dose LMWH prophylaxis be used for preventing first or recurrent VTE in pregnant women? 
18. Should V/Q scanning vs other diagnostic tools be used for diagnosis of pulmonary embolism in pregnant women with suspected pulmonary embolism? 
19. Should no further investigations vs additional investigations (serial compression or duplex ultrasound, magnetic resonance imaging, or venography) be used for diagnosis of DVT in pregnant women with suspected DVT and initial negative compression or duplex ultrasound with imaging of the iliac veins? 
1. Should antithrombotic therapy (UFH or LMWH) vs no antithrombotics be used for pregnant women with acute VTE? 
2. Should anticoagulant intervention vs no anticoagulant intervention be used for pregnant women with proven superficial vein thrombosis? 
3. Should LMWH twice per day vs LMWH once per day be used for pregnant women with acute VTE? 
4. Should routine anti-FXa monitoring to guide dose adjustment vs no monitoring be used in pregnant women receiving therapeutic-dose LMWH for the treatment of VTE? 
5. Should catheter-directed thrombolytic therapy vs no catheter-directed thrombolytic therapy be used in addition to anticoagulant therapy in pregnant women with acute lower-extremity DVT? 
6. Should thrombolytic therapy vs no thrombolytic therapy be used in addition to anticoagulant therapy in pregnant women with acute hemodynamically significant pulmonary embolism or pulmonary embolism with significant right ventricular dysfunction? 
7. Should outpatient therapy vs hospital admission be used in the initial treatment of pregnant patients with low-risk acute VTE? 
8. Should scheduled delivery with discontinuation of LMWH vs cessation of LMWH with spontaneous onset of labor be used for pregnant women receiving therapeutic-dose LMWH? 
9. Should scheduled delivery with prior discontinuation of prophylactic-dose LMWH vs cessation of prophylactic LMWH at the onset of spontaneous labor be used for pregnant women receiving prophylactic-dose LMWH? 
10. Should one particular anticoagulant vs any other anticoagulant be used for breastfeeding women who have an indication for anticoagulation? 
11. Should anticoagulant prophylaxis vs no anticoagulant prophylaxis be used for prevention of VTE in women undergoing assisted reproduction? 
12. Should antepartum anticoagulant prophylaxis vs no antepartum anticoagulant prophylaxis be used for pregnant women with prior VTE? 
13. Should postpartum anticoagulant prophylaxis vs no postpartum anticoagulant prophylaxis be used for pregnant women with prior VTE? 
14. Should antepartum anticoagulant prophylaxis vs no antepartum anticoagulant prophylaxis be used for pregnant women with thrombophilia to prevent a first venous thromboembolic event? 
15. Should postpartum anticoagulant prophylaxis vs no postpartum anticoagulant prophylaxis be used for pregnant women with thrombophilia to prevent a first venous thromboembolic event? 
16. Should anticoagulant prophylaxis vs no anticoagulant prophylaxis be used for pregnant women with clinical risk factors for VTE? 
17. Should intermediate-dose LMWH prophylaxis vs standard-dose LMWH prophylaxis be used for preventing first or recurrent VTE in pregnant women? 
18. Should V/Q scanning vs other diagnostic tools be used for diagnosis of pulmonary embolism in pregnant women with suspected pulmonary embolism? 
19. Should no further investigations vs additional investigations (serial compression or duplex ultrasound, magnetic resonance imaging, or venography) be used for diagnosis of DVT in pregnant women with suspected DVT and initial negative compression or duplex ultrasound with imaging of the iliac veins? 
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