Demographic, clinical, and laboratory characteristics of patients with and without HIT
| . | HIT−, N = 249 . | HIT+, N = 43 . | P* . |
|---|---|---|---|
| Demographic characteristics | |||
| Age, median (IQR), y | 67 (58-75) | 64 (53-74) | .163 |
| Male sex, n (%) | 128 (51.4) | 27 (62.8) | .167 |
| Race, n (%) | .786 | ||
| White | 178 (71.5) | 34 (79.1) | |
| Hispanic | 4 (1.6) | 0 (0.0) | |
| African American | 60 (24.1) | 9 (20.9) | |
| Asian | 7 (2.8) | 0 (0.0) | |
| Clinical characteristics at enrollment | |||
| Type of patient, n (%) | .319† | ||
| Medical | 113 (45.4) | 16 (37.2) | |
| Surgical | 136 (54.6) | 27 (62.8) | |
| Cardiothoracic | 109 (43.8) | 16 (37.2) | |
| Orthopedic | 1 (0.4) | 0 (0.0) | |
| Trauma | 5 (2.0) | 1 (2.3) | |
| Vascular | 4 (1.6) | 1 (2.3) | |
| Other | 17 (6.8) | 9 (20.9) | |
| ICU, n (%) | 148 (59.4) | 22 (51.2) | .310‡ |
| Medical | 49 (19.6) | 9 (20.9) | |
| Cardiothoracic | 84 (33.7) | 8 (18.6) | |
| General surgical | 15 (6.0) | 5 (11.6) | |
| Hospital type, n (%) | .091 | ||
| Academic | 158 (63.5) | 33 (76.7) | |
| Community | 91 (36.6) | 10 (23.3) | |
| Type of heparin, n (%) | .567 | ||
| UFH | 160 (75.5) | 31 (79.5) | |
| LMWH | 25 (11.8) | 3 (7.7) | |
| Both | 27 (12.6) | 5 (12.8) | |
| Platelet count at enrollment, median (IQR), ×109/L | 60.5 (38-86.5) | 51 (32-94) | .569 |
| Thrombosis at enrollment,§ n (%) | <.001|| | ||
| Absent | 168 (67.4) | 15 (34.88) | |
| Present | 81 (32.5) | 28 (65.1) | |
| Venous | 45 (18.1) | 21 (48.8) | |
| Arterial | 34 (13.6) | 6 (13.9) | |
| Both | 2 (0.8) | 1 (2.3) | |
| HIT laboratory test results | |||
| HIT ELISA (OD), n (%) | <.001 | ||
| 0-0.39 | 209 (83.9) | 0 (0) | |
| 0.4-0.99 | 21 (8.4) | 3 (7.0) | |
| ≥1.0 | 19 (7.6) | 40 (93.0) | |
| SRA, n (%) | <.001 | ||
| Positive | 1 (0.4) | 29 (67.4) | |
| Negative | 244 (97.9) | 13 (30.2) | |
| Indeterminate | 2 (0.8) | 1 (2.3) | |
| Missing | 2 (0.8) | 0 (0) | |
| In-hospital and 30-d outcomes | |||
| Length of stay, median (IQR), d | 16 (10-29) | 22 (14-30) | .067 |
| In-hospital mortality, n (%) | .969 | ||
| Alive | 186 (74.7) | 32 (74.4) | |
| Deceased | 63 (25.3) | 11 (25.6) | |
| 30-d mortality, n (%) | .893 | ||
| Alive | 161 (64.7) | 27 (62.8) | |
| Deceased | 75 (30.1) | 13 (30.2) | |
| Lost to follow-up | 13 (5.2) | 3 (7.0) | |
| . | HIT−, N = 249 . | HIT+, N = 43 . | P* . |
|---|---|---|---|
| Demographic characteristics | |||
| Age, median (IQR), y | 67 (58-75) | 64 (53-74) | .163 |
| Male sex, n (%) | 128 (51.4) | 27 (62.8) | .167 |
| Race, n (%) | .786 | ||
| White | 178 (71.5) | 34 (79.1) | |
| Hispanic | 4 (1.6) | 0 (0.0) | |
| African American | 60 (24.1) | 9 (20.9) | |
| Asian | 7 (2.8) | 0 (0.0) | |
| Clinical characteristics at enrollment | |||
| Type of patient, n (%) | .319† | ||
| Medical | 113 (45.4) | 16 (37.2) | |
| Surgical | 136 (54.6) | 27 (62.8) | |
| Cardiothoracic | 109 (43.8) | 16 (37.2) | |
| Orthopedic | 1 (0.4) | 0 (0.0) | |
| Trauma | 5 (2.0) | 1 (2.3) | |
| Vascular | 4 (1.6) | 1 (2.3) | |
| Other | 17 (6.8) | 9 (20.9) | |
| ICU, n (%) | 148 (59.4) | 22 (51.2) | .310‡ |
| Medical | 49 (19.6) | 9 (20.9) | |
| Cardiothoracic | 84 (33.7) | 8 (18.6) | |
| General surgical | 15 (6.0) | 5 (11.6) | |
| Hospital type, n (%) | .091 | ||
| Academic | 158 (63.5) | 33 (76.7) | |
| Community | 91 (36.6) | 10 (23.3) | |
| Type of heparin, n (%) | .567 | ||
| UFH | 160 (75.5) | 31 (79.5) | |
| LMWH | 25 (11.8) | 3 (7.7) | |
| Both | 27 (12.6) | 5 (12.8) | |
| Platelet count at enrollment, median (IQR), ×109/L | 60.5 (38-86.5) | 51 (32-94) | .569 |
| Thrombosis at enrollment,§ n (%) | <.001|| | ||
| Absent | 168 (67.4) | 15 (34.88) | |
| Present | 81 (32.5) | 28 (65.1) | |
| Venous | 45 (18.1) | 21 (48.8) | |
| Arterial | 34 (13.6) | 6 (13.9) | |
| Both | 2 (0.8) | 1 (2.3) | |
| HIT laboratory test results | |||
| HIT ELISA (OD), n (%) | <.001 | ||
| 0-0.39 | 209 (83.9) | 0 (0) | |
| 0.4-0.99 | 21 (8.4) | 3 (7.0) | |
| ≥1.0 | 19 (7.6) | 40 (93.0) | |
| SRA, n (%) | <.001 | ||
| Positive | 1 (0.4) | 29 (67.4) | |
| Negative | 244 (97.9) | 13 (30.2) | |
| Indeterminate | 2 (0.8) | 1 (2.3) | |
| Missing | 2 (0.8) | 0 (0) | |
| In-hospital and 30-d outcomes | |||
| Length of stay, median (IQR), d | 16 (10-29) | 22 (14-30) | .067 |
| In-hospital mortality, n (%) | .969 | ||
| Alive | 186 (74.7) | 32 (74.4) | |
| Deceased | 63 (25.3) | 11 (25.6) | |
| 30-d mortality, n (%) | .893 | ||
| Alive | 161 (64.7) | 27 (62.8) | |
| Deceased | 75 (30.1) | 13 (30.2) | |
| Lost to follow-up | 13 (5.2) | 3 (7.0) | |
IQR, interquartile range; LMWH, low-molecular-weight heparin; UFH, unfractionated heparin.
Wilcoxon rank sum test for continuous variables and the χ2 or Fisher's exact test for categorical variables.
P value represents statistical comparison of proportion of patients on medical or surgical service.
P value represents statistical comparison of proportion of patients on an ICU service.
Only thromboses confirmed by imaging are included.
P value represents statistical comparison of proportion of patients with thrombosis present.