Cox regression models comparing the risk of an event between different genetic ungroups defined by the UKALL-CNA and revised genetic classifiers
| Classifier . | Overall . | MRD adapted . | Non–MRD adapted . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Univariate models | |||||||||
| UKALL-CNA | |||||||||
| CNA-GR vs CNA-IR | 0.48 | 0.40-0.57 | <.001 | 0.51 | 0.39-0.66 | <.001 | 0.45 | 0.35-0.58 | <.001 |
| CNA-PR vs CNA-IR | 1.43 | 1.12-1.82 | .004 | 1.39 | 0.96-2.01 | .08 | 1.42 | 1.03-1.96 | .03 |
| Genetic risk | |||||||||
| GEN-GR vs GEN-VGR | 1.68 | 1.29-2.19 | <.001 | 1.33 | 0.93-1.91 | .12 | 2.19 | 1.46-3.29 | <.001 |
| GEN-IR vs GEN-GR | 2.05 | 1.65-2.53 | <.001 | 2.03 | 1.46-2.82 | <.001 | 2.03 | 1.53-2.69 | <.001 |
| GEN-PR vs GEN-IR | 1.95 | 1.51-2.53 | <.001 | 1.83 | 1.23-2.72 | .003 | 2.13 | 1.51-3.01 | <.001 |
| Models stratified by treatment risk group | |||||||||
| UKALL-CNA | |||||||||
| CNA-GR vs CNA-IR | 0.53 | 0.44-0.64 | <.001 | 0.53 | 0.41-0.70 | <.001 | 0.52 | 0.41-0.67 | <.001 |
| CNA-PR vs CNA-IR | 1.31 | 1.02-1.66 | .03 | 1.27 | 0.87-1.84 | .22 | 1.33 | 0.97-1.83 | .08 |
| Genetic risk | |||||||||
| GEN-GR vs GEN-VGR | 1.62 | 1.24-2.12 | <.001 | 1.30 | 0.90-1.89 | .16 | 2.06 | 1.37-3.09 | .001 |
| GEN-IR vs GEN-GR | 1.86 | 1.50-2.31 | <.001 | 1.89 | 1.36-2.65 | <.001 | 1.82 | 1.37-2.42 | <.001 |
| GEN-PR vs GEN-IR | 1.36 | 1.02-1.81 | .04 | 1.46 | 0.94-2.26 | .09 | 1.36 | 0.94-1.99 | .11 |
| Classifier . | Overall . | MRD adapted . | Non–MRD adapted . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Univariate models | |||||||||
| UKALL-CNA | |||||||||
| CNA-GR vs CNA-IR | 0.48 | 0.40-0.57 | <.001 | 0.51 | 0.39-0.66 | <.001 | 0.45 | 0.35-0.58 | <.001 |
| CNA-PR vs CNA-IR | 1.43 | 1.12-1.82 | .004 | 1.39 | 0.96-2.01 | .08 | 1.42 | 1.03-1.96 | .03 |
| Genetic risk | |||||||||
| GEN-GR vs GEN-VGR | 1.68 | 1.29-2.19 | <.001 | 1.33 | 0.93-1.91 | .12 | 2.19 | 1.46-3.29 | <.001 |
| GEN-IR vs GEN-GR | 2.05 | 1.65-2.53 | <.001 | 2.03 | 1.46-2.82 | <.001 | 2.03 | 1.53-2.69 | <.001 |
| GEN-PR vs GEN-IR | 1.95 | 1.51-2.53 | <.001 | 1.83 | 1.23-2.72 | .003 | 2.13 | 1.51-3.01 | <.001 |
| Models stratified by treatment risk group | |||||||||
| UKALL-CNA | |||||||||
| CNA-GR vs CNA-IR | 0.53 | 0.44-0.64 | <.001 | 0.53 | 0.41-0.70 | <.001 | 0.52 | 0.41-0.67 | <.001 |
| CNA-PR vs CNA-IR | 1.31 | 1.02-1.66 | .03 | 1.27 | 0.87-1.84 | .22 | 1.33 | 0.97-1.83 | .08 |
| Genetic risk | |||||||||
| GEN-GR vs GEN-VGR | 1.62 | 1.24-2.12 | <.001 | 1.30 | 0.90-1.89 | .16 | 2.06 | 1.37-3.09 | .001 |
| GEN-IR vs GEN-GR | 1.86 | 1.50-2.31 | <.001 | 1.89 | 1.36-2.65 | <.001 | 1.82 | 1.37-2.42 | <.001 |
| GEN-PR vs GEN-IR | 1.36 | 1.02-1.81 | .04 | 1.46 | 0.94-2.26 | .09 | 1.36 | 0.94-1.99 | .11 |
CI, confidence interval; VGR, very good risk.