Adverse events
| Adverse event* . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . | Any grade . | Grade ≥3 . |
|---|---|---|---|---|---|---|---|
| Hematologic, n (%) | |||||||
| Neutropenia | 9 (8) | 20 (17) | 50 (42) | 20 (17) | — | 99 (83) | 70 (58) |
| Lymphopenia | 8 (7) | 9 (8) | 57 (48) | 15 (13) | — | 89 (74) | 72 (60) |
| Leukopenia | 13 (11) | 32 (27) | 32 (27) | 9 (8) | — | 86 (72) | 41 (34) |
| Thrombocytopenia | 27 (23) | 21 (18) | 14 (12) | 23 (19) | — | 85 (71) | 37 (31) |
| Anemia | 5 (4) | 36 (30) | 27 (23) | 6 (5) | — | 74 (62) | 33 (28) |
| Nonhematologic, n (%) | |||||||
| Fatigue | 24 (20) | 43 (36) | 15 (13) | 3 (3) | — | 85 (71) | 18 (15) |
| Hyperglycemia | 28 (23) | 31 (26) | 15 (13) | 3 (3) | — | 77 (64) | 18 (15) |
| Hypoglycemia | 46 (38) | 17 (14) | 5 (4) | 5 (4) | — | 73 (61) | 10 (8) |
| Hypoalbuminemia | 28 (23) | 39 (33) | 3 (3) | — | — | 70 (58) | 3 (3) |
| Hypocalcemia | 36 (30) | 24 (20) | 5 (4) | 1 (1) | — | 66 (55) | 6 (5) |
| Hyponatremia | 52 (43) | 5 (4) | 5 (4) | — | — | 62 (52) | 5 (4) |
| Hypomagnesemia | 45 (38) | 6 (5) | — | — | — | 51 (43) | — |
| Increased creatinine | 28 (23) | 13 (11) | 4 (3) | 1 (1) | — | 46 (38) | 5 (4) |
| Diarrhea | 29 (24) | 9 (8) | 6 (5) | — | — | 44 (37) | 6 (5) |
| Back pain | 20 (17) | 14 (12) | 5 (4) | — | — | 39 (33) | 5 (4) |
| Edema | 26 (22) | 12 (10) | — | — | — | 38 (32) | — |
| Dysgeusia | 26 (22) | 10 (8) | 1 (1) | — | — | 37 (31) | 1 (1) |
| Peripheral neuropathy | 21 (18) | 15 (13) | 1 (1) | — | — | 37 (31) | 1 (1) |
| Elevated ALT | 30 (25) | 4 (3) | 2 (2) | — | — | 36 (30) | 2 (2) |
| Elevated ALK | 33 (28) | 2 (2) | 1 (1) | — | — | 36 (30) | 1 (1) |
| Insomnia | 28 (23) | 7 (6) | 1 (1) | — | — | 36 (30) | 1 (1) |
| Muscle weakness | 15 (13) | 9 (8) | 9 (8) | — | — | 33 (28) | 9 (8) |
| Constipation | 29 (24) | 3 (3) | — | — | — | 32 (27) | — |
| Hypophosphatemia | 8 (7) | 6 (5) | 17 (14) | — | — | 31 (26) | 17 (14) |
| Dyspnea | 20 (17) | 8 (7) | 2 (2) | — | — | 30 (25) | 2 (2) |
| Tremor | 24 (10) | 4 (3) | 1 (1) | — | — | 29 (24) | 1 (1) |
| URI | 7 (6) | 20 (17) | — | — | — | 27 (23) | — |
| Dizziness | 17 (14) | 6 (5) | 2 (2) | — | — | 25 (21) | 2 (2) |
| Cough | 22 (18) | 2 (2) | — | — | — | 24 (20) | — |
| Nausea | 15 (13) | 6 (5) | 2 (2) | — | — | 23 (19) | 2 (2) |
| Infection, other† | 9 (8) | 8 (7) | 3 (3) | — | — | 20 (17) | 3 (3) |
| Elevated AST | 15 (13) | 3 (3) | 1 (1) | — | — | 19 (16) | 1 (1) |
| Lung infection | 1 (1) | 3 (3) | 14 (12) | — | 1 (1) | 19 (16) | 15 (13) |
| Rash | 10 (8) | 5 (4) | — | — | — | 15 (13) | — |
| Generalized weakness | 5 (4) | 4 (3) | 4 (3) | — | — | 13 (11) | 4 (3) |
| Deep vein thrombosis | 1 (1) | 6 (5) | — | — | — | 7 (6) | — |
| Febrile neutropenia | 1 (1) | — | 3 (3) | 1 (1) | — | 5 (4) | 4 (3) |
| Atrial fibrillation | — | 1 (1) | 1 (1) | — | — | 2 (2) | 1 (1) |
| Adverse event* . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . | Any grade . | Grade ≥3 . |
|---|---|---|---|---|---|---|---|
| Hematologic, n (%) | |||||||
| Neutropenia | 9 (8) | 20 (17) | 50 (42) | 20 (17) | — | 99 (83) | 70 (58) |
| Lymphopenia | 8 (7) | 9 (8) | 57 (48) | 15 (13) | — | 89 (74) | 72 (60) |
| Leukopenia | 13 (11) | 32 (27) | 32 (27) | 9 (8) | — | 86 (72) | 41 (34) |
| Thrombocytopenia | 27 (23) | 21 (18) | 14 (12) | 23 (19) | — | 85 (71) | 37 (31) |
| Anemia | 5 (4) | 36 (30) | 27 (23) | 6 (5) | — | 74 (62) | 33 (28) |
| Nonhematologic, n (%) | |||||||
| Fatigue | 24 (20) | 43 (36) | 15 (13) | 3 (3) | — | 85 (71) | 18 (15) |
| Hyperglycemia | 28 (23) | 31 (26) | 15 (13) | 3 (3) | — | 77 (64) | 18 (15) |
| Hypoglycemia | 46 (38) | 17 (14) | 5 (4) | 5 (4) | — | 73 (61) | 10 (8) |
| Hypoalbuminemia | 28 (23) | 39 (33) | 3 (3) | — | — | 70 (58) | 3 (3) |
| Hypocalcemia | 36 (30) | 24 (20) | 5 (4) | 1 (1) | — | 66 (55) | 6 (5) |
| Hyponatremia | 52 (43) | 5 (4) | 5 (4) | — | — | 62 (52) | 5 (4) |
| Hypomagnesemia | 45 (38) | 6 (5) | — | — | — | 51 (43) | — |
| Increased creatinine | 28 (23) | 13 (11) | 4 (3) | 1 (1) | — | 46 (38) | 5 (4) |
| Diarrhea | 29 (24) | 9 (8) | 6 (5) | — | — | 44 (37) | 6 (5) |
| Back pain | 20 (17) | 14 (12) | 5 (4) | — | — | 39 (33) | 5 (4) |
| Edema | 26 (22) | 12 (10) | — | — | — | 38 (32) | — |
| Dysgeusia | 26 (22) | 10 (8) | 1 (1) | — | — | 37 (31) | 1 (1) |
| Peripheral neuropathy | 21 (18) | 15 (13) | 1 (1) | — | — | 37 (31) | 1 (1) |
| Elevated ALT | 30 (25) | 4 (3) | 2 (2) | — | — | 36 (30) | 2 (2) |
| Elevated ALK | 33 (28) | 2 (2) | 1 (1) | — | — | 36 (30) | 1 (1) |
| Insomnia | 28 (23) | 7 (6) | 1 (1) | — | — | 36 (30) | 1 (1) |
| Muscle weakness | 15 (13) | 9 (8) | 9 (8) | — | — | 33 (28) | 9 (8) |
| Constipation | 29 (24) | 3 (3) | — | — | — | 32 (27) | — |
| Hypophosphatemia | 8 (7) | 6 (5) | 17 (14) | — | — | 31 (26) | 17 (14) |
| Dyspnea | 20 (17) | 8 (7) | 2 (2) | — | — | 30 (25) | 2 (2) |
| Tremor | 24 (10) | 4 (3) | 1 (1) | — | — | 29 (24) | 1 (1) |
| URI | 7 (6) | 20 (17) | — | — | — | 27 (23) | — |
| Dizziness | 17 (14) | 6 (5) | 2 (2) | — | — | 25 (21) | 2 (2) |
| Cough | 22 (18) | 2 (2) | — | — | — | 24 (20) | — |
| Nausea | 15 (13) | 6 (5) | 2 (2) | — | — | 23 (19) | 2 (2) |
| Infection, other† | 9 (8) | 8 (7) | 3 (3) | — | — | 20 (17) | 3 (3) |
| Elevated AST | 15 (13) | 3 (3) | 1 (1) | — | — | 19 (16) | 1 (1) |
| Lung infection | 1 (1) | 3 (3) | 14 (12) | — | 1 (1) | 19 (16) | 15 (13) |
| Rash | 10 (8) | 5 (4) | — | — | — | 15 (13) | — |
| Generalized weakness | 5 (4) | 4 (3) | 4 (3) | — | — | 13 (11) | 4 (3) |
| Deep vein thrombosis | 1 (1) | 6 (5) | — | — | — | 7 (6) | — |
| Febrile neutropenia | 1 (1) | — | 3 (3) | 1 (1) | — | 5 (4) | 4 (3) |
| Atrial fibrillation | — | 1 (1) | 1 (1) | — | — | 2 (2) | 1 (1) |
ALK, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; URI, upper respiratory infection.
If an adverse event occurred in the same patient more than once, the most severe grade of the adverse event is reported.
Includes mucosal, skin, eye, bronchial, cellulitis, ear, fungal, sinus, and tooth infections.