Adverse events experienced by at least 2 patients on study, ordered by decreasing frequency of occurrence of any grade toxicity
| Event . | Any grade . | Grade 3 or 4 . |
|---|---|---|
| ALT increase | 17 (63) | 14 (52) |
| AST increase | 17 (63) | 11 (41) |
| Decreased neutrophil count | 13 (48) | 9 (33) |
| Fever | 11 (41) | 0 (0) |
| Colitis/diarrhea | 10 (37) | 4 (15) |
| Fatigue | 8 (30) | 0 (0) |
| Rash (maculopapular) | 8 (30) | 2 (7) |
| Nausea | 7 (26) | 0 (0) |
| Infusion-related reaction | 6 (22) | 1 (4) |
| Myalgia | 5 (19) | 1 (4) |
| Abdominal pain | 4 (15) | 0 (0) |
| Chills | 4 (15) | 0 (0) |
| Anemia | 3 (11) | 1 (4) |
| Constipation | 3 (11) | 0 (0) |
| Cough | 3 (11) | 0 (0) |
| Dysgeusia | 3 (11) | 0 (0) |
| Limb edema | 3 (11) | 0 (0) |
| Other infections and infestations | 3 (11) | 2 (7) |
| Pneumonitis | 3 (11) | 2 (7) |
| Vomiting | 3 (11) | 0 (0) |
| Increased alkaline phosphatase | 2 (7) | 1 (4) |
| Anorexia | 2 (7) | 0 (0) |
| Increased bilirubin | 2 (7) | 0 (0) |
| Bronchial infection | 2 (7) | 0 (0) |
| Dyspnea | 2 (7) | 0 (0) |
| Gastroesophageal reflux disease | 2 (7) | 0 (0) |
| Hyponatremia | 2 (7) | 2 (7) |
| Lung infection | 2 (7) | 2 (7) |
| Malaise | 2 (7) | 0 (0) |
| Acneiform rash | 2 (7) | 0 (0) |
| Weight loss | 2 (7) | 1 (4) |
| Decreased white blood cell count | 2 (7) | 0 (0) |
| Event . | Any grade . | Grade 3 or 4 . |
|---|---|---|
| ALT increase | 17 (63) | 14 (52) |
| AST increase | 17 (63) | 11 (41) |
| Decreased neutrophil count | 13 (48) | 9 (33) |
| Fever | 11 (41) | 0 (0) |
| Colitis/diarrhea | 10 (37) | 4 (15) |
| Fatigue | 8 (30) | 0 (0) |
| Rash (maculopapular) | 8 (30) | 2 (7) |
| Nausea | 7 (26) | 0 (0) |
| Infusion-related reaction | 6 (22) | 1 (4) |
| Myalgia | 5 (19) | 1 (4) |
| Abdominal pain | 4 (15) | 0 (0) |
| Chills | 4 (15) | 0 (0) |
| Anemia | 3 (11) | 1 (4) |
| Constipation | 3 (11) | 0 (0) |
| Cough | 3 (11) | 0 (0) |
| Dysgeusia | 3 (11) | 0 (0) |
| Limb edema | 3 (11) | 0 (0) |
| Other infections and infestations | 3 (11) | 2 (7) |
| Pneumonitis | 3 (11) | 2 (7) |
| Vomiting | 3 (11) | 0 (0) |
| Increased alkaline phosphatase | 2 (7) | 1 (4) |
| Anorexia | 2 (7) | 0 (0) |
| Increased bilirubin | 2 (7) | 0 (0) |
| Bronchial infection | 2 (7) | 0 (0) |
| Dyspnea | 2 (7) | 0 (0) |
| Gastroesophageal reflux disease | 2 (7) | 0 (0) |
| Hyponatremia | 2 (7) | 2 (7) |
| Lung infection | 2 (7) | 2 (7) |
| Malaise | 2 (7) | 0 (0) |
| Acneiform rash | 2 (7) | 0 (0) |
| Weight loss | 2 (7) | 1 (4) |
| Decreased white blood cell count | 2 (7) | 0 (0) |
Data are n (%).