Table 1. Baseline demographic... | American Society of Hematology

Table 1.

Baseline demographic characteristics and DXA results for the SCCRIP BMD Cohort

Variable	All (N = 306)		Female (n = 153)		Male (n = 153)
Variable	School-age (n = 96 [31.4%])	Adolescent (n = 210 [68.6%])	School-age (n = 46 [30.1%])	Adolescent (n = 107 [69.9%])	School-age (n = 50 [32.7%)	Adolescent (n = 103 [67.3%])
SCD genotype
HbSS/Sβ⁰-thalassemia	61 (63.5)	136 (64.8)	27 (58.7)	67 (62.6)	34 (68.0)	69 (67.0)
HbSC	28 (29.2)	52 (24.8)	16 (34.8)	30 (28.0)	12 (24.0)	22 (21.4)
HbSβ⁺-thalassemia	7 (7.3)	22 (10.5)	3 (6.5)	10 (9.4)	4 (8.0)	12 (11.6)
Age at DXA, y	7.2 ± 1.13*	14.8 ± 2.16*	7.0 ± 0.78*	14.9 ± 2.16*	7.4 ± 1.37*	14.7 ± 2.17*
Race/ethnicity
African American	94 (97.9)	210 (100.0)	44 (95.6)	107 (100)	50 (100)	103(100)
Other	2 (2.1)	0 (0)	2 (4.4)	0 (0)	0 (0)	0 (0)
Hydroxyurea use
No	42 (43.8)	83 (39.5)	21 (45.6)	44 (41.1)	21 (42.0)	39 (37.9)
Yes	54 (56.2)	127 (60.5)	25 (54.4)	63 (58.9)	29 (58.0)	64 (62.1)
Chronic RBC transfusions†
No	95 (99.0)	202 (96.2)	46 (100)	101 (94.4)	49 (98.0)	101 (98.1)
Yes	1 (1.0)	8 (3.8)	0 (0)	6 (5.6)	1 (2.0)	2 (1.9)
Height, cm	122.2 ± 9.74*	160.0 ± 11.53*	120.7 ± 7.97*	158.1 ± 8.51*	123.5 ± 11.03*	161.9 ± 13.77*
Height-for-age z scores	−0.12 ± 1.07	−0.21 ± 1.11	−0.19 ± 0.96	−0.14 ± 1.09	−0.05 ± 1.17	−0.29 ± 1.13
TBLH aBMD, g/cm²	0.58 ± 0.07*	0.86 ± 0.11*	0.57 ± 0.06*	0.85 ± 0.09*	0.59 ± 0.08*	0.86 ± 0.14*
TBLH aBMD z score
Normal	73 (76.0)	137 (65.2)	35 (76.1)	73 (68.2)	38 (76.0)	64 (62.1)
Low	23 (24.0)	73 (34.8)	11 (23.9)	34 (31.8)	12 (24.0)	39 (37.9)
TBLH aBMD z score	−1.14 ± 1.03*	−1.60 ± 1.25*	−1.07 ± 1.06*	−1.54 ± 1.20*	−1.20 ± 1.01*	−1.65 ± 1.30*
TBLHHt-aBMD z score
Normal	92 (95.8)*	158 (75.2)*	44 (95.6)*	84 (78.5)*	48 (96.0)*	74 (71.8)*
Low	4 (4.2)*	52 (24.8)*	2 (4.4)*	23 (21.5)*	2 (4.0)*	29 (28.2)*
TBLH Ht-aBMD z score	−0.80 ± 0.69*	−1.36 ± 1.05*	−0.81 ± 0.72*	−1.34 ± 1.02*	−0.80 ± 0.67*	−1.37 ± 1.08*

Variable	All (N = 306)		Female (n = 153)		Male (n = 153)
Variable	School-age (n = 96 [31.4%])	Adolescent (n = 210 [68.6%])	School-age (n = 46 [30.1%])	Adolescent (n = 107 [69.9%])	School-age (n = 50 [32.7%)	Adolescent (n = 103 [67.3%])
SCD genotype
HbSS/Sβ⁰-thalassemia	61 (63.5)	136 (64.8)	27 (58.7)	67 (62.6)	34 (68.0)	69 (67.0)
HbSC	28 (29.2)	52 (24.8)	16 (34.8)	30 (28.0)	12 (24.0)	22 (21.4)
HbSβ⁺-thalassemia	7 (7.3)	22 (10.5)	3 (6.5)	10 (9.4)	4 (8.0)	12 (11.6)
Age at DXA, y	7.2 ± 1.13*	14.8 ± 2.16*	7.0 ± 0.78*	14.9 ± 2.16*	7.4 ± 1.37*	14.7 ± 2.17*
Race/ethnicity
African American	94 (97.9)	210 (100.0)	44 (95.6)	107 (100)	50 (100)	103(100)
Other	2 (2.1)	0 (0)	2 (4.4)	0 (0)	0 (0)	0 (0)
Hydroxyurea use
No	42 (43.8)	83 (39.5)	21 (45.6)	44 (41.1)	21 (42.0)	39 (37.9)
Yes	54 (56.2)	127 (60.5)	25 (54.4)	63 (58.9)	29 (58.0)	64 (62.1)
Chronic RBC transfusions†
No	95 (99.0)	202 (96.2)	46 (100)	101 (94.4)	49 (98.0)	101 (98.1)
Yes	1 (1.0)	8 (3.8)	0 (0)	6 (5.6)	1 (2.0)	2 (1.9)
Height, cm	122.2 ± 9.74*	160.0 ± 11.53*	120.7 ± 7.97*	158.1 ± 8.51*	123.5 ± 11.03*	161.9 ± 13.77*
Height-for-age z scores	−0.12 ± 1.07	−0.21 ± 1.11	−0.19 ± 0.96	−0.14 ± 1.09	−0.05 ± 1.17	−0.29 ± 1.13
TBLH aBMD, g/cm²	0.58 ± 0.07*	0.86 ± 0.11*	0.57 ± 0.06*	0.85 ± 0.09*	0.59 ± 0.08*	0.86 ± 0.14*
TBLH aBMD z score
Normal	73 (76.0)	137 (65.2)	35 (76.1)	73 (68.2)	38 (76.0)	64 (62.1)
Low	23 (24.0)	73 (34.8)	11 (23.9)	34 (31.8)	12 (24.0)	39 (37.9)
TBLH aBMD z score	−1.14 ± 1.03*	−1.60 ± 1.25*	−1.07 ± 1.06*	−1.54 ± 1.20*	−1.20 ± 1.01*	−1.65 ± 1.30*
TBLHHt-aBMD z score
Normal	92 (95.8)*	158 (75.2)*	44 (95.6)*	84 (78.5)*	48 (96.0)*	74 (71.8)*
Low	4 (4.2)*	52 (24.8)*	2 (4.4)*	23 (21.5)*	2 (4.0)*	29 (28.2)*
TBLH Ht-aBMD z score	−0.80 ± 0.69*	−1.36 ± 1.05*	−0.81 ± 0.72*	−1.34 ± 1.02*	−0.80 ± 0.67*	−1.37 ± 1.08*

Data are presented as n (%) or mean ± standard deviation.

Hb, hemoglobin; RBC, red blood cell.

P < .05 between school-age vs adolescent values.

†

Defined as ≥4 RBC transfusions per year.

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