EFS estimates determined by using different induction failure definitions for randomized trials CALGB 10201 and CALGB 10603
| Induction failure definition . | Median (95% CI) EFS by arm, mo . | Comparison of EFS between arms . | ||
|---|---|---|---|---|
| Arm 1 . | Arm 2 . | HR (95% CI) . | P . | |
| CALGB 10201 | ||||
| D1 | 2 (2.0-3.4) | 2.0 (NA-NA) | 1.03 (0.86-1.23) | .770 |
| D2 | 3.3 (2.4-5.3) | 2.7 (1.9-4.3) | 1.02 (0.85-1.22) | .850 |
| D3 | 4.5 (3.4-5.7) | 3.8 (2.3-5.7) | 1.04 (0.87-1.25) | .670 |
| CALGB 10603 | ||||
| D1 | 7.8 (4.7-10.6) | 2.8 (2.0-5.9) | 0.79 (0.67-0.94) | .005 |
| D2 | 9.5 (7.3-13.1) | 5.5 (3.0-6.7) | 0.76 (0.64-0.90) | .002 |
| D3 | 14.5 (10.6-17.3) | 7.2 (6.0-8.9) | 0.71 (0.60-0.85) | <.001 |
| Induction failure definition . | Median (95% CI) EFS by arm, mo . | Comparison of EFS between arms . | ||
|---|---|---|---|---|
| Arm 1 . | Arm 2 . | HR (95% CI) . | P . | |
| CALGB 10201 | ||||
| D1 | 2 (2.0-3.4) | 2.0 (NA-NA) | 1.03 (0.86-1.23) | .770 |
| D2 | 3.3 (2.4-5.3) | 2.7 (1.9-4.3) | 1.02 (0.85-1.22) | .850 |
| D3 | 4.5 (3.4-5.7) | 3.8 (2.3-5.7) | 1.04 (0.87-1.25) | .670 |
| CALGB 10603 | ||||
| D1 | 7.8 (4.7-10.6) | 2.8 (2.0-5.9) | 0.79 (0.67-0.94) | .005 |
| D2 | 9.5 (7.3-13.1) | 5.5 (3.0-6.7) | 0.76 (0.64-0.90) | .002 |
| D3 | 14.5 (10.6-17.3) | 7.2 (6.0-8.9) | 0.71 (0.60-0.85) | <.001 |
HR, hazard ratio; NA, not reached.