Table 3.

Effect of characteristics at detection of del(17p) on survival measures in patients with acquired del(17p) (n = 76)

Independent variable No. of patients with available data in the subgroupsPFSOS
P for univariable analysisHR (95% CI) for multivariable analysisP for multivariable analysisP for univariable analysisHR (95% CI) for multivariable analysisP for multivariable analysis
Age ≥65 vs <65, y 39 vs 37 .157 NI — .147 NI —  
Serum creatinine >2 vs ≤2 mg/dL 4 vs 74 .311 NI — .846 NI —  
Bone marrow PCs ≥50% 37 vs 38 .512 NI — .651 NI —  
ISS III vs I/II 13 vs 43 .090 1.62 (0.78-3.35) .193 .047 1.60 (0.79-3.25) .189  
Increased vs normal LDH 21 vs 41 .839 NI - .056 1.29 (0.59-2.82) .530  
High-risk vs no high-risk translocation 14 vs 62 .868 NI — .873 NI —  
Monosomy 13 vs no monosomy 13 41 vs 35 .374 NI — .730 NI —  
HRD vs no HRD 41 vs 35 .531 NI — .957 NI —  
High vs low PC proliferative rate 32 vs 33 .036 1.58 (0.93-2.69) .093 .004 2.28 (1.31-3.96) .004  
PI and IMiD refractory vs not refractory 30 vs 46 .080 1.05 (0.54-2.05) .883 .015 1.39 (0.70-2.74) .347  
Percentage of PCs with del(17p)         
 ≥20 vs <20 66 vs 5 .277 NI — .686 NI —  
 ≥30 vs <30 59 vs 12 .032 1.53 (0.67-3.52) .312 .490 NI —  
 ≥40 vs <40 53 vs 18 .009 2.21 (1.21-4.01) .009 .589 NI —  
 ≥50 vs <50 50 vs 21 .009 1.57 (0.80-3.10) .193 .445 NI —  
 ≥60 vs <60 49 vs 22 .009 1.57 (0.80-3.10) .193 .566 NI —  
Independent variable No. of patients with available data in the subgroupsPFSOS
P for univariable analysisHR (95% CI) for multivariable analysisP for multivariable analysisP for univariable analysisHR (95% CI) for multivariable analysisP for multivariable analysis
Age ≥65 vs <65, y 39 vs 37 .157 NI — .147 NI —  
Serum creatinine >2 vs ≤2 mg/dL 4 vs 74 .311 NI — .846 NI —  
Bone marrow PCs ≥50% 37 vs 38 .512 NI — .651 NI —  
ISS III vs I/II 13 vs 43 .090 1.62 (0.78-3.35) .193 .047 1.60 (0.79-3.25) .189  
Increased vs normal LDH 21 vs 41 .839 NI - .056 1.29 (0.59-2.82) .530  
High-risk vs no high-risk translocation 14 vs 62 .868 NI — .873 NI —  
Monosomy 13 vs no monosomy 13 41 vs 35 .374 NI — .730 NI —  
HRD vs no HRD 41 vs 35 .531 NI — .957 NI —  
High vs low PC proliferative rate 32 vs 33 .036 1.58 (0.93-2.69) .093 .004 2.28 (1.31-3.96) .004  
PI and IMiD refractory vs not refractory 30 vs 46 .080 1.05 (0.54-2.05) .883 .015 1.39 (0.70-2.74) .347  
Percentage of PCs with del(17p)         
 ≥20 vs <20 66 vs 5 .277 NI — .686 NI —  
 ≥30 vs <30 59 vs 12 .032 1.53 (0.67-3.52) .312 .490 NI —  
 ≥40 vs <40 53 vs 18 .009 2.21 (1.21-4.01) .009 .589 NI —  
 ≥50 vs <50 50 vs 21 .009 1.57 (0.80-3.10) .193 .445 NI —  
 ≥60 vs <60 49 vs 22 .009 1.57 (0.80-3.10) .193 .566 NI —  

All variables with a P < .1 in univariable analysis were included in the multivariable model. The final multivariable model included 49 patients for PFS and OS in whom the parameters were available.

HR, hazard ratio; HRD, hyperdiploidy; NI, not included in analysis.

View Large
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal