Type of thrombosis before/at MPN diagnosis and during follow-up stratified by second cancer
| . | Carcinoma . | NM-Skin cancer . | HSC . | Melanoma . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls . | Cases . | P* . | Controls . | Cases . | P* . | Controls . | Cases . | P* . | Controls . | Cases . | P* . | |
| n = 812 . | n = 426 . | n = 244 . | n = 127 . | n = 116 . | n = 62 . | n = 62 . | n = 32 . | |||||
| Thrombosis before/at MPN diagnosis | 180 (22.2) | 84 (19.7) | .318 | 50 (20.5) | 27 (21.3) | .863 | 20 (17.2) | 12 (19.4) | .726 | 12 (19.4) | 5 (15.6) | .656 |
| Arterial thrombosis | 127 (15.6) | 57 (13.4) | .288 | 36 (14.8) | 21 (16.5) | .652 | 14 (12.1) | 8 (12.9) | .872 | 9 (14.5) | 3 (9.4) | .745 |
| Acute coronary syndrome | 54 (6.7) | 20 (4.7) | .168 | 20 (8.2) | 9 (7.1) | .705 | 4 (3.4) | 3 (4.8) | .696 | 2 (3.2) | 2 (6.3) | .603 |
| TIA | 32 (3.9) | 10 (2.3) | .141 | 7 (2.9) | 7 (5.5) | .205 | 5 (4.3) | 4 (6.5) | .721 | 4 (6.5) | 1 (3.1) | .658 |
| Ischemic stroke | 26 (3.2) | 20 (4.7) | .187 | 7 (2.9) | 4 (3.1) | .99 | 4 (3.4) | 0 (0.0) | .299 | 2 (3.2) | 0 (0.0) | .546 |
| Other arterial thrombosis | 15 (1.8) | 7 (1.6) | .796 | 2 (0.8) | 1 (0.8) | .99 | 1 (0.9) | 1 (1.6) | .99 | 1 (1.6) | 0 (0.0) | .99 |
| Venous thrombosis | 52 (6.4) | 27 (6.3) | .964 | 14 (5.7) | 6 (4.7) | .682 | 6 (5.2) | 4 (6.5) | .741 | 3 (4.8) | 2 (6.3) | .99 |
| DVT of the legs and/or pulmonary embolism | 23 (2.8) | 12 (2.8) | .987 | 6 (2.5) | 3 (2.4) | .99 | 3 (2.6) | 1 (1.6) | .99 | 1 (1.6) | 1 (3.1) | .99 |
| Splanchnic vein thrombosis | 12 (1.5) | 9 (2.1) | .411 | 5 (2.0) | 2 (1.6) | .99 | 2 (1.7) | 1 (1.6) | .99 | 1 (1.6) | 0 (0.0) | .99 |
| Cerebral vein thrombosis | 1 (0.1) | 2 (0.5) | .274 | 0 (0.0) | 0 (0.0) | .00 | 1 (0.9) | 1 (1.6) | .99 | 0 (0.0) | 0 (0.0) | .000 |
| Other venous thrombosis | 16 (2.0) | 4 (0.9) | .236 | 3 (1.2) | 1 (0.8) | .99 | 0 (0.0) | 1 (1.6) | .348 | 1 (1.6) | 1 (3.1) | .99 |
| Thrombosis during follow-up | 67 (8.3) | 51 (12.0) | .034 | 21 (8.6) | 15 (11.8) | .322 | 7 (6.0) | 5 (2.0) | .607 | 5 (8.1) | 4 (12.5) | .489 |
| Arterial thrombosis | 32 (3.9) | 29 (6.8) | .027 | 11 (4.5) | 6 (4.7) | .925 | 2 (1.7) | 2 (3.2) | .611 | 1 (1.6) | 3 (9.4) | .113 |
| Acute coronary syndrome | 8 (1.0) | 6 (1.4) | .503 | 4 (1.6) | 2 (1.6) | .99 | 0 (0.0) | 0 (0.0) | — | 1 (1.6) | 1 (3.1) | .99 |
| TIA | 14 (1.7) | 14 (3.3) | .079 | 1 (0.4) | 1 (0.8) | .99 | 1 (0.9) | 1 (1.6) | .99 | 0 (0.0) | 1 (3.1) | .340 |
| Ischemic stroke | 7 (0.9) | 6 (1.4) | .370 | 2 (0.8) | 1 (0.8) | .99 | 1 (0.9) | 1 (1.6) | .99 | 0 (0.0) | 1 (3.1) | .340 |
| Other arterial thrombosis | 3 (0.4) | 3 (0.7) | .420 | 4 (1.6) | 2 (1.6) | .99 | 0 (0.0) | 0 (0.0) | — | 0 (0.0) | 0 (0.0) | — |
| Venous thrombosis | 34 (4.2) | 22 (5.2) | .432 | 10 (4.1) | 9 (7.1) | .215 | 5 (4.3) | 3 (4.8) | .99 | 4 (6.5) | 1 (3.1) | .658 |
| DVT of the legs and/or pulmonary embolism | 21 (2.6) | 11 (2.6) | .997 | 6 (2.5) | 7 (5.5) | .129 | 2 (1.7) | 2 (3.2) | .611 | 2 (3.2) | 0 (0.0) | .546 |
| Splanchnic vein thrombosis | 3 (0.4) | 7 (1.6) | .038 | 1 (0.4) | 1 (0.8) | .99 | 0 (0.0) | 0 (0.0) | — | 1 (1.6) | 1 (3.1) | .99 |
| Cerebral vein thrombosis | 0 (0.0) | 1 (0.2) | .344 | 0 (0.0) | 0 (0.0) | — | 1 (0.9) | 0 (0.0) | .99 | 0 (0.0) | 0 (0.0) | — |
| Other venous thrombosis | 10 (1.2) | 3 (0.7) | .560 | 3 (1.2) | 1 (0.8) | .99 | 2 (1.7) | 1 (1.6) | .99 | 1 (1.6) | 0 (0.0) | .99 |
| . | Carcinoma . | NM-Skin cancer . | HSC . | Melanoma . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls . | Cases . | P* . | Controls . | Cases . | P* . | Controls . | Cases . | P* . | Controls . | Cases . | P* . | |
| n = 812 . | n = 426 . | n = 244 . | n = 127 . | n = 116 . | n = 62 . | n = 62 . | n = 32 . | |||||
| Thrombosis before/at MPN diagnosis | 180 (22.2) | 84 (19.7) | .318 | 50 (20.5) | 27 (21.3) | .863 | 20 (17.2) | 12 (19.4) | .726 | 12 (19.4) | 5 (15.6) | .656 |
| Arterial thrombosis | 127 (15.6) | 57 (13.4) | .288 | 36 (14.8) | 21 (16.5) | .652 | 14 (12.1) | 8 (12.9) | .872 | 9 (14.5) | 3 (9.4) | .745 |
| Acute coronary syndrome | 54 (6.7) | 20 (4.7) | .168 | 20 (8.2) | 9 (7.1) | .705 | 4 (3.4) | 3 (4.8) | .696 | 2 (3.2) | 2 (6.3) | .603 |
| TIA | 32 (3.9) | 10 (2.3) | .141 | 7 (2.9) | 7 (5.5) | .205 | 5 (4.3) | 4 (6.5) | .721 | 4 (6.5) | 1 (3.1) | .658 |
| Ischemic stroke | 26 (3.2) | 20 (4.7) | .187 | 7 (2.9) | 4 (3.1) | .99 | 4 (3.4) | 0 (0.0) | .299 | 2 (3.2) | 0 (0.0) | .546 |
| Other arterial thrombosis | 15 (1.8) | 7 (1.6) | .796 | 2 (0.8) | 1 (0.8) | .99 | 1 (0.9) | 1 (1.6) | .99 | 1 (1.6) | 0 (0.0) | .99 |
| Venous thrombosis | 52 (6.4) | 27 (6.3) | .964 | 14 (5.7) | 6 (4.7) | .682 | 6 (5.2) | 4 (6.5) | .741 | 3 (4.8) | 2 (6.3) | .99 |
| DVT of the legs and/or pulmonary embolism | 23 (2.8) | 12 (2.8) | .987 | 6 (2.5) | 3 (2.4) | .99 | 3 (2.6) | 1 (1.6) | .99 | 1 (1.6) | 1 (3.1) | .99 |
| Splanchnic vein thrombosis | 12 (1.5) | 9 (2.1) | .411 | 5 (2.0) | 2 (1.6) | .99 | 2 (1.7) | 1 (1.6) | .99 | 1 (1.6) | 0 (0.0) | .99 |
| Cerebral vein thrombosis | 1 (0.1) | 2 (0.5) | .274 | 0 (0.0) | 0 (0.0) | .00 | 1 (0.9) | 1 (1.6) | .99 | 0 (0.0) | 0 (0.0) | .000 |
| Other venous thrombosis | 16 (2.0) | 4 (0.9) | .236 | 3 (1.2) | 1 (0.8) | .99 | 0 (0.0) | 1 (1.6) | .348 | 1 (1.6) | 1 (3.1) | .99 |
| Thrombosis during follow-up | 67 (8.3) | 51 (12.0) | .034 | 21 (8.6) | 15 (11.8) | .322 | 7 (6.0) | 5 (2.0) | .607 | 5 (8.1) | 4 (12.5) | .489 |
| Arterial thrombosis | 32 (3.9) | 29 (6.8) | .027 | 11 (4.5) | 6 (4.7) | .925 | 2 (1.7) | 2 (3.2) | .611 | 1 (1.6) | 3 (9.4) | .113 |
| Acute coronary syndrome | 8 (1.0) | 6 (1.4) | .503 | 4 (1.6) | 2 (1.6) | .99 | 0 (0.0) | 0 (0.0) | — | 1 (1.6) | 1 (3.1) | .99 |
| TIA | 14 (1.7) | 14 (3.3) | .079 | 1 (0.4) | 1 (0.8) | .99 | 1 (0.9) | 1 (1.6) | .99 | 0 (0.0) | 1 (3.1) | .340 |
| Ischemic stroke | 7 (0.9) | 6 (1.4) | .370 | 2 (0.8) | 1 (0.8) | .99 | 1 (0.9) | 1 (1.6) | .99 | 0 (0.0) | 1 (3.1) | .340 |
| Other arterial thrombosis | 3 (0.4) | 3 (0.7) | .420 | 4 (1.6) | 2 (1.6) | .99 | 0 (0.0) | 0 (0.0) | — | 0 (0.0) | 0 (0.0) | — |
| Venous thrombosis | 34 (4.2) | 22 (5.2) | .432 | 10 (4.1) | 9 (7.1) | .215 | 5 (4.3) | 3 (4.8) | .99 | 4 (6.5) | 1 (3.1) | .658 |
| DVT of the legs and/or pulmonary embolism | 21 (2.6) | 11 (2.6) | .997 | 6 (2.5) | 7 (5.5) | .129 | 2 (1.7) | 2 (3.2) | .611 | 2 (3.2) | 0 (0.0) | .546 |
| Splanchnic vein thrombosis | 3 (0.4) | 7 (1.6) | .038 | 1 (0.4) | 1 (0.8) | .99 | 0 (0.0) | 0 (0.0) | — | 1 (1.6) | 1 (3.1) | .99 |
| Cerebral vein thrombosis | 0 (0.0) | 1 (0.2) | .344 | 0 (0.0) | 0 (0.0) | — | 1 (0.9) | 0 (0.0) | .99 | 0 (0.0) | 0 (0.0) | — |
| Other venous thrombosis | 10 (1.2) | 3 (0.7) | .560 | 3 (1.2) | 1 (0.8) | .99 | 2 (1.7) | 1 (1.6) | .99 | 1 (1.6) | 0 (0.0) | .99 |
Data are expressed as the number of patients (% of total patients in the group).
DVT, deep venous thrombosis; TIA, transient ischemic attack.
χ2 test or Fisher’s exact test (when appropriate) for categorical data. For 1 patient, type of thrombosis before/at MPN diagnosis and during follow-up were missing.