Differentially expressed genes involved in DNA repair and genome stability in spontaneously regressed CLL compared with indolent M-CLL
| Gene name . | logFC . | P . | Function . |
|---|---|---|---|
| SETMAR | 0.81 | .002 | Component of the telomerase complex essential for telomere maintenance |
| FANCL | 0.71 | .002 | Mediates monoubiquitination of FANCD2, an important step in DNA damage response |
| MLH3 | 0.68 | <.001 | Important component of DNA mismatch repair |
| RAD50 | 0.67 | <.001 | Essential mediator of double-strand break repair, DNA recombination and telomere maintenance |
| ALKBH8 | 0.58 | .001 | tRNA nucleoside involved in DNA damage response |
| POLA1 | 0.58 | .001 | Regulates the initiation of DNA replication |
| PRIM2 | 0.57 | .001 | Synthesizes the small RNA primers used to generate Okazaki fragments in the lagging strand during DNA replication |
| ATM | 0.56 | .002 | Essential mediator in double-strand break repair, DNA recombination and apoptosis in response to genotoxic stress |
| MMS22L | 0.52 | .003 | Involved in the repair of stalled or collapsed replication forks by recombination |
| ATRX | 0.48 | .002 | Involved in gene regulation and chromatin modeling during DNA replication |
| POT1 | 0.44 | .003 | Component of the telomerase complex essential for telomere maintenance |
| APEX1 | −0.68 | <.001 | Involved in cellular response to oxidative stress |
| Gene name . | logFC . | P . | Function . |
|---|---|---|---|
| SETMAR | 0.81 | .002 | Component of the telomerase complex essential for telomere maintenance |
| FANCL | 0.71 | .002 | Mediates monoubiquitination of FANCD2, an important step in DNA damage response |
| MLH3 | 0.68 | <.001 | Important component of DNA mismatch repair |
| RAD50 | 0.67 | <.001 | Essential mediator of double-strand break repair, DNA recombination and telomere maintenance |
| ALKBH8 | 0.58 | .001 | tRNA nucleoside involved in DNA damage response |
| POLA1 | 0.58 | .001 | Regulates the initiation of DNA replication |
| PRIM2 | 0.57 | .001 | Synthesizes the small RNA primers used to generate Okazaki fragments in the lagging strand during DNA replication |
| ATM | 0.56 | .002 | Essential mediator in double-strand break repair, DNA recombination and apoptosis in response to genotoxic stress |
| MMS22L | 0.52 | .003 | Involved in the repair of stalled or collapsed replication forks by recombination |
| ATRX | 0.48 | .002 | Involved in gene regulation and chromatin modeling during DNA replication |
| POT1 | 0.44 | .003 | Component of the telomerase complex essential for telomere maintenance |
| APEX1 | −0.68 | <.001 | Involved in cellular response to oxidative stress |
Transcriptome sequencing data derived from sorted CD19+CD5+ CLL cells were analyzed comparing spontaneously regressed CLL (n = 15) against indolent M-CLL (n = 17). Positive logFC values identify genes that are upregulated in spontaneously regressed CLL, whereas negative logFC values identify genes that are downregulated.
tRNA, transfer RNA.