Multivariable analysis for OS
| Variable . | HR . | 95% CI . | P . |
|---|---|---|---|
| TP53 VAF | 1.018 | 1.010-1.025 | <.001 |
| One TP53 mutation | 1.25 | 0.78-2.00 | .35 |
| Multiple TP53 mutations | 1.39 | 0.88-2.19 | .15 |
| TP53 deletion | 0.95 | 0.68-1.32 | .75 |
| IPSS-R category | |||
| Absolute neutrophil count | 0.78 | 0.47-1.30 | .35 |
| BM blast count | 1.32 | 1.18-1.47 | <.001 |
| Cytogenetic risk category | 1.32 | 1.17-1.50 | <.001 |
| Hemoglobin | 1.72 | 1.39-2.12 | <.001 |
| Platelets | 2.55 | 1.92-3.40 | <.001 |
| Variable . | HR . | 95% CI . | P . |
|---|---|---|---|
| TP53 VAF | 1.018 | 1.010-1.025 | <.001 |
| One TP53 mutation | 1.25 | 0.78-2.00 | .35 |
| Multiple TP53 mutations | 1.39 | 0.88-2.19 | .15 |
| TP53 deletion | 0.95 | 0.68-1.32 | .75 |
| IPSS-R category | |||
| Absolute neutrophil count | 0.78 | 0.47-1.30 | .35 |
| BM blast count | 1.32 | 1.18-1.47 | <.001 |
| Cytogenetic risk category | 1.32 | 1.17-1.50 | <.001 |
| Hemoglobin | 1.72 | 1.39-2.12 | <.001 |
| Platelets | 2.55 | 1.92-3.40 | <.001 |