Tumor antigens in hematologic malignancies.
| Tumor Antigen Category . | Example . |
|---|---|
| Abbreviations: CML, chronic myeloid leukemia; Ig, immunoglobulin; APL, acute promyelocytic leukemia; NHL, non-Hodgkin’s lymphoma; AML, acute myeloid leukemia; EBV, Epstein-Barr virus. | |
| Unique antigens | bcr/abl protein (CML) |
| Immunoglobulin idiotype (myeloma, NHL) | |
| T cell receptor idiotype (T cell lymphomas) | |
| pml/rar-α protein (APL) | |
| Shared tumor-specific antigens | Mage |
| Bage | |
| NY-ESO-1 | |
| telomerase | |
| Tissue-specific differentiation antigens | Proteinase-3 (AML, CML) |
| WT-1 (AML) | |
| Oncogene/tumor suppressor antigens | p53 |
| mutated ras proteins | |
| Virus-associated antigens | EBV (Hodgkin’s, Burkitt’s lymphoma) |
| Tumor Antigen Category . | Example . |
|---|---|
| Abbreviations: CML, chronic myeloid leukemia; Ig, immunoglobulin; APL, acute promyelocytic leukemia; NHL, non-Hodgkin’s lymphoma; AML, acute myeloid leukemia; EBV, Epstein-Barr virus. | |
| Unique antigens | bcr/abl protein (CML) |
| Immunoglobulin idiotype (myeloma, NHL) | |
| T cell receptor idiotype (T cell lymphomas) | |
| pml/rar-α protein (APL) | |
| Shared tumor-specific antigens | Mage |
| Bage | |
| NY-ESO-1 | |
| telomerase | |
| Tissue-specific differentiation antigens | Proteinase-3 (AML, CML) |
| WT-1 (AML) | |
| Oncogene/tumor suppressor antigens | p53 |
| mutated ras proteins | |
| Virus-associated antigens | EBV (Hodgkin’s, Burkitt’s lymphoma) |