Autologous stem cell transplantation versus conventional chemotherapy. Results of randomized trials.
| Study (reference) . | No. of Patients . | Age . | CR Rate (%) (CC vs ASCT) . | p value . | Median EFS (months) (CC vs ASCT) . | p value . | Median OS (months) (CC vs ASCT) . | p value . |
|---|---|---|---|---|---|---|---|---|
| Abbreviations: ASCT, autologous stem cell transplantation; CC, conventional chemotherapy; IFM, Intergroupe Francophone du Myelome; MRC, Medical Research Council; MAG, Myelome Auto Greffe; PETHEMA, Spanish Cooperative Group; USIG, US Inter Group; IMMSG, Italian Multiple Myeloma Study Group; CR, complete remission; EFS, event-free survival; NS, not significant | ||||||||
| IFM90 (1) | 200 | ≤ 65 | 5 vs 22 | < 0.001 | 18 vs 28 | 0.01 | 44 vs 57 | 0.03 |
| MRC7 (2) | 401 | ≤ 64 | 8 vs 44 | < 0.001 | 19 vs 31 | < 0.001 | 42 vs 54 | < 0.001 |
| MAG91 (3) | 190 | 55–65 | 19 vs 25 | 0.05 | 45 vs 42 | NS | ||
| PETHEMA (4) | 164 | ≤ 65 | 11 vs 30 | 0.002 | 34 vs 42 | NS | 67 vs 65 | NS |
| USIG (6) | 50 | 15 vs 17 | NS | 21 vs 25 | 0.05 | 53 vs 58 | NS | |
| IMMSG (5) | 195 | 50–70 | 7 vs 26 | < 0.0001 | 16 vs 28 | 0.0036 | 43 vs 58+ | 0.0008 |
| Study (reference) . | No. of Patients . | Age . | CR Rate (%) (CC vs ASCT) . | p value . | Median EFS (months) (CC vs ASCT) . | p value . | Median OS (months) (CC vs ASCT) . | p value . |
|---|---|---|---|---|---|---|---|---|
| Abbreviations: ASCT, autologous stem cell transplantation; CC, conventional chemotherapy; IFM, Intergroupe Francophone du Myelome; MRC, Medical Research Council; MAG, Myelome Auto Greffe; PETHEMA, Spanish Cooperative Group; USIG, US Inter Group; IMMSG, Italian Multiple Myeloma Study Group; CR, complete remission; EFS, event-free survival; NS, not significant | ||||||||
| IFM90 (1) | 200 | ≤ 65 | 5 vs 22 | < 0.001 | 18 vs 28 | 0.01 | 44 vs 57 | 0.03 |
| MRC7 (2) | 401 | ≤ 64 | 8 vs 44 | < 0.001 | 19 vs 31 | < 0.001 | 42 vs 54 | < 0.001 |
| MAG91 (3) | 190 | 55–65 | 19 vs 25 | 0.05 | 45 vs 42 | NS | ||
| PETHEMA (4) | 164 | ≤ 65 | 11 vs 30 | 0.002 | 34 vs 42 | NS | 67 vs 65 | NS |
| USIG (6) | 50 | 15 vs 17 | NS | 21 vs 25 | 0.05 | 53 vs 58 | NS | |
| IMMSG (5) | 195 | 50–70 | 7 vs 26 | < 0.0001 | 16 vs 28 | 0.0036 | 43 vs 58+ | 0.0008 |