Diagnostic guidelines for juvenile myelomonocytic leukemia (JMML) (adapted from5).
| Suggestive clinical features | Hepatosplenomegaly |
| Lymphadenopathy | |
| Pallor | |
| Fever | |
| Skin rash | |
| Laboratory criteria | No Ph chromosome, no BCR-ABL rearrangement |
| Minimal criteria (all 3 must be fulfilled) | Peripheral blood monocyte count > 1 × 109/L Bone marrow blast < 20% |
| Criteria for definite diagnosis (at least 2 must be fulfilled) | Hemoglobin F increased for age |
| Myeloid precursors on peripheral blood smear | |
| White blood cell count > 10 × 109/L | |
| Clonal abnormality | |
| Granulocyte-macrophage colony-stimulating factor (GM- CSF) hypersensitivity of myeloid progenitors in vitro |
| Suggestive clinical features | Hepatosplenomegaly |
| Lymphadenopathy | |
| Pallor | |
| Fever | |
| Skin rash | |
| Laboratory criteria | No Ph chromosome, no BCR-ABL rearrangement |
| Minimal criteria (all 3 must be fulfilled) | Peripheral blood monocyte count > 1 × 109/L Bone marrow blast < 20% |
| Criteria for definite diagnosis (at least 2 must be fulfilled) | Hemoglobin F increased for age |
| Myeloid precursors on peripheral blood smear | |
| White blood cell count > 10 × 109/L | |
| Clonal abnormality | |
| Granulocyte-macrophage colony-stimulating factor (GM- CSF) hypersensitivity of myeloid progenitors in vitro |