Classification of Waldenström’s macroglobulinemia (WM) and related disorders.
| Disorder . | Laboratory Features . | Clinical Features . |
|---|---|---|
| a sIg+CD19+CD20+CD22+CD79+ | ||
| b Chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma, extranodal marginal-zone lymphoma, follicular lymphoma and mantle-cell lymphoma. | ||
| Abbreviations: HCD, heavy-chain disease; MGUS, monoclonal gammopathy of undetermined significance. | ||
| WM | Lymphoplasmacytic infiltrate in marrow Specific immunophenotypea Serum monoclonal IgM | May be symptomatic or asymptomatic |
| IgM-related disorder | No marrow infiltration | Symptomatic, e.g., peripheral neuropathy, cryoglobulins, cold agglutinin disease, AL amyloidosis |
| IgM MGUS | No marrow infiltrate | Asymptomatic |
| Other B cell lymphoproliferative disordersb | Differentiate by immunophenotype and morphological characteristics | |
| μ-HCD | Heavy-chain fragment with no associated light chain | |
| IgM myeloma | IgM-producing plasma cells (cytoplasmic IgM+, CD20+ CD138+, t(11;14)) | Possibly associated with lytic skeletal lesions and hypercalcemia |
| Disorder . | Laboratory Features . | Clinical Features . |
|---|---|---|
| a sIg+CD19+CD20+CD22+CD79+ | ||
| b Chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma, extranodal marginal-zone lymphoma, follicular lymphoma and mantle-cell lymphoma. | ||
| Abbreviations: HCD, heavy-chain disease; MGUS, monoclonal gammopathy of undetermined significance. | ||
| WM | Lymphoplasmacytic infiltrate in marrow Specific immunophenotypea Serum monoclonal IgM | May be symptomatic or asymptomatic |
| IgM-related disorder | No marrow infiltration | Symptomatic, e.g., peripheral neuropathy, cryoglobulins, cold agglutinin disease, AL amyloidosis |
| IgM MGUS | No marrow infiltrate | Asymptomatic |
| Other B cell lymphoproliferative disordersb | Differentiate by immunophenotype and morphological characteristics | |
| μ-HCD | Heavy-chain fragment with no associated light chain | |
| IgM myeloma | IgM-producing plasma cells (cytoplasmic IgM+, CD20+ CD138+, t(11;14)) | Possibly associated with lytic skeletal lesions and hypercalcemia |