Table 6. Analysis of baseline variables... | American Society of Hematology

Table 6.

Analysis of baseline variables for their impact on hematologic response

Factors	No. subjects	No. subjects with hematologic response	Univariate P	Multivariate P(n = 56)
Sex
Male	38	28	.179	NA
Female	25	22
Age^*
Younger than 60 y	38	33	.078	NA
Older than 60 y	25	17
Disease duration
Fewer than 12 mo	16	14	.426	NA
Longer than 12 mo	46	36
Prior therapy
None, HU, IFN	35	30	.170	NA
Others	28	20
Prior 6- Thioguanine
Yes	58	46	.971	NA
No	5	4
Phase^*
Chronic	20	20	.005	NS
Accelerated + blastic	43	30
Clonal evolution^*†
Yes	25	16	.016	.010
No	34	31
Splenomegaly
Yes	43	35	.772	NA
No	13	10
Hemoglobin level^*
At least 100 g/L	24	15	.016	NS
Less than 100 g/L	38	34
White blood cell count
At least 10 × 10⁹/L	19	16	.543	NA
Fewer than 10 × 10⁹/L	44	34
Platelet count^*
No more than 100 × 10⁹/L	16	9	.095	NS
More than 100 × 10⁹/L but less than 450 × 10⁹/L	28	24
More than 450	17	14
Blasts in PB^*‡
5% or less	41	38	<.001	.001
Greater than 5%	20	10
Basophils in PB
7% or less	42	32	.540	NA
Greater than 7%	18	15
Blasts in BM
5% or less	29	29	.942	NA
Greater than 5%	25	15
Mutation
Yes	14	9	.123	NA
No	49	41

Factors	No. subjects	No. subjects with hematologic response	Univariate P	Multivariate P(n = 56)
Sex
Male	38	28	.179	NA
Female	25	22
Age^*
Younger than 60 y	38	33	.078	NA
Older than 60 y	25	17
Disease duration
Fewer than 12 mo	16	14	.426	NA
Longer than 12 mo	46	36
Prior therapy
None, HU, IFN	35	30	.170	NA
Others	28	20
Prior 6- Thioguanine
Yes	58	46	.971	NA
No	5	4
Phase^*
Chronic	20	20	.005	NS
Accelerated + blastic	43	30
Clonal evolution^*†
Yes	25	16	.016	.010
No	34	31
Splenomegaly
Yes	43	35	.772	NA
No	13	10
Hemoglobin level^*
At least 100 g/L	24	15	.016	NS
Less than 100 g/L	38	34
White blood cell count
At least 10 × 10⁹/L	19	16	.543	NA
Fewer than 10 × 10⁹/L	44	34
Platelet count^*
No more than 100 × 10⁹/L	16	9	.095	NS
More than 100 × 10⁹/L but less than 450 × 10⁹/L	28	24
More than 450	17	14
Blasts in PB^*‡
5% or less	41	38	<.001	.001
Greater than 5%	20	10
Basophils in PB
7% or less	42	32	.540	NA
Greater than 7%	18	15
Blasts in BM
5% or less	29	29	.942	NA
Greater than 5%	25	15
Mutation
Yes	14	9	.123	NA
No	49	41

NS indicates not significant; NA, not available.

Factors with P < .1 in univariate analysis were included in the multivariate model.

Estimated odds ratio = .086; 95% Wald confidence interval = 0.013-0.568.

Estimated odds ratio = .050; 95% Wald confidence interval = 0.008-0.322.