Regression equation for modeling warfarin daily dose requirements based on age, genotype, and height
Model, x variables . | Regression equation . | P . | R2 for model, % . |
|---|---|---|---|
| Age | √D = 2.85 – 0.0137 (Age) | .001 | 16.7 |
| CYP2C9 genotype | √D = 2.01 – 0.252 (CYP*2) – 0.454 (CYP*3) | .001 | 17.5 |
| VKORC1 genotype | √D = 2.41 – 0.297 (VKORC1) | .001 | 15.0 |
| Height | √D = 2.12 + 0.0237 (Height) | .001 | 16.0 |
| Age, height, CYP2C9 genotype, VKORC1 genotype | √Dose = 0.628 – 0.0135 (Age) – 0.240 (CYP*2) – 0.370 (CYP*3) – 0.241 (VKOR) + 0.0162 (Height) | .001 | 54.2 |
Model, x variables . | Regression equation . | P . | R2 for model, % . |
|---|---|---|---|
| Age | √D = 2.85 – 0.0137 (Age) | .001 | 16.7 |
| CYP2C9 genotype | √D = 2.01 – 0.252 (CYP*2) – 0.454 (CYP*3) | .001 | 17.5 |
| VKORC1 genotype | √D = 2.41 – 0.297 (VKORC1) | .001 | 15.0 |
| Height | √D = 2.12 + 0.0237 (Height) | .001 | 16.0 |
| Age, height, CYP2C9 genotype, VKORC1 genotype | √Dose = 0.628 – 0.0135 (Age) – 0.240 (CYP*2) – 0.370 (CYP*3) – 0.241 (VKOR) + 0.0162 (Height) | .001 | 54.2 |
Age: input age in years; CYP2C9 genotype: input 0, 1, or 2 for the number of *2 and *3 alleles within the patient's genotype; VKORC1 genotype: input 1 for GG, 2 for GA, and 3 for AA; height: input height in centimeters.