Table 2.

Expression of adhesion molecules on BEnd5 cells in vitro


BEnd5 cell culture treatment

E-selectin

P-selectin

ICAM-1

ICAM-2

VCAM-1
R-848   +   ++   0   +++   +  
R-848 + spleen cells   ++   0   ++   ++   0  
R-848 + blood cells   +   +   ++   +++   +  
TNF-α
 
++
 
+++
 
+++
 
++
 
+
 

BEnd5 cell culture treatment

E-selectin

P-selectin

ICAM-1

ICAM-2

VCAM-1
R-848   +   ++   0   +++   +  
R-848 + spleen cells   ++   0   ++   ++   0  
R-848 + blood cells   +   +   ++   +++   +  
TNF-α
 
++
 
+++
 
+++
 
++
 
+
 

Immunohistology of BEnd5 cells was examined for the expression level of the indicated molecule.

0 indicates no detectable expression; +++, very high expression.

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