Table 1. Response of Procr Lox and Procr... | American Society of Hematology

Table 1.

Response of ProcrLox and Procr^+/+mice to low-dose factor Xa/PCPS challenge

	2 months old			8 months old
Parameter	Procr^Lox	*Procr*^+/+	Procr^Lox	*Procr*^+/+	Procr^Lox	*Procr*^+/+
TAT, apparent μg/L	2.1 ± 0.4*	1.4 ± 0.3	6.5 ± 2.1†	1.8 ± 0.3	202 ± 29†	88 ± 19
Fibrinogen, % normal C57BL/6J plasma pool	90.7 ± 3.6	99.1 ± 5.1	74.2 ± 4.8†	105.4 ± 5.3	26.1 ± 3.8†	80.7 ± 6.7
Platelet count, × 10⁹/L	731 ± 136	801 ± 40	756 ± 119*	946 ± 64	353 ± 49†	576 ± 47

	2 months old			8 months old
Parameter	Procr^Lox	*Procr*^+/+	Procr^Lox	*Procr*^+/+	Procr^Lox	*Procr*^+/+
TAT, apparent μg/L	2.1 ± 0.4*	1.4 ± 0.3	6.5 ± 2.1†	1.8 ± 0.3	202 ± 29†	88 ± 19
Fibrinogen, % normal C57BL/6J plasma pool	90.7 ± 3.6	99.1 ± 5.1	74.2 ± 4.8†	105.4 ± 5.3	26.1 ± 3.8†	80.7 ± 6.7
Platelet count, × 10⁹/L	731 ± 136	801 ± 40	756 ± 119*	946 ± 64	353 ± 49†	576 ± 47

TAT level, fibrinogen, and platelet count were determined as described. Values represent the mean ± SD in Procr^+/+ and ProcrLox mice at 2 and 8 months of age. These parameters were also measured in 2-month-old animals after infusion with low-dose factor Xa/PCPS. n = 5 for each group.

P < .05.

†

P < .01.

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