Effect of PSC-833 on outcome at 5 years
. | DNR/Ara-C; N = 211 . | . | DNR/Ara-C + PSC-833; N = 208 . | . | . | . | ||
|---|---|---|---|---|---|---|---|---|
| End point . | No. of events . | Probability of outcome at 5 y, % (95% CI) . | No. of events . | Probability of outcome at 5 y, % (95% CI) . | P . | RR*(95% CI) . | ||
| CR rate | 101 | 48 (41-55) | 112 | 54 (47-61) | .22 | 1.27 (0.87-1.87) | ||
| Event-free survival | 192 | 8 (5-12) | 192 | 7 (4-11) | .53 | 1.07 (0.87-1.30) | ||
| Overall survival | 181 | 10 (6-15) | 182 | 10 (6-15) | .52 | 1.07 (0.87-1.32) | ||
| Disease-free survival after 1st CR | 82 | 17 (11-26) | 96 | 13 (8-20) | .06 | 1.33 (0.99-1.78) | ||
| Relapse after 1st CR† | 72 | 72 ± 5 | 82 | 74 ± 4 | .10 | 1.31 (0.95-1.79) | ||
| Death in 1st Cr† | 10 | 10 ± 3 | 14 | 13 ± 3 | .36 | 1.47 (0.65-3.32) | ||
. | DNR/Ara-C; N = 211 . | . | DNR/Ara-C + PSC-833; N = 208 . | . | . | . | ||
|---|---|---|---|---|---|---|---|---|
| End point . | No. of events . | Probability of outcome at 5 y, % (95% CI) . | No. of events . | Probability of outcome at 5 y, % (95% CI) . | P . | RR*(95% CI) . | ||
| CR rate | 101 | 48 (41-55) | 112 | 54 (47-61) | .22 | 1.27 (0.87-1.87) | ||
| Event-free survival | 192 | 8 (5-12) | 192 | 7 (4-11) | .53 | 1.07 (0.87-1.30) | ||
| Overall survival | 181 | 10 (6-15) | 182 | 10 (6-15) | .52 | 1.07 (0.87-1.32) | ||
| Disease-free survival after 1st CR | 82 | 17 (11-26) | 96 | 13 (8-20) | .06 | 1.33 (0.99-1.78) | ||
| Relapse after 1st CR† | 72 | 72 ± 5 | 82 | 74 ± 4 | .10 | 1.31 (0.95-1.79) | ||
| Death in 1st Cr† | 10 | 10 ± 3 | 14 | 13 ± 3 | .36 | 1.47 (0.65-3.32) | ||
RR indicates relative risk of event.
For CR rate, RR should be read as odds ratio (OR); OR and 95% CI are based on logistic regression. For all survival end points, RR should be read as hazard ratio (HR); HR and 95% CI are based on Cox regression analysis.
Relapse after first CR and death in first CR are competing risks; plus-minus values are the actuarial means ± standard error.