Table 1.

Patient laboratory values before and during treatment with PKC412

Initial Presentation
Pretreatment
Cycle 1
Cycle 2
Cycle 3/Relapse
Date   Apr 2003   Jun 2003   Jun-Jul 2003   Jul-Aug 2003   Aug-Sep 2003  
Hematology      
WBCs/mm3*  15.8   8.4   8.0   7.9   12.2  
Differential count, %       
Segmented neutrophils   14   19   46   44   20  
Bands   10   6   29   26   7  
Lymphocytes   19   19   11   17   7  
Monocytes   8   5   7   8   0  
Eosinophils   0   2   0   1   0  
Basophils   0   0   0   0   0  
Immature myeloids   31   3   2   4   51  
Blasts   5   0   0   0   8  
Mast cells   11   46   5   0   2  
Nucleated red blood cells/100 WBCs   7   47   4   4   0  
Hemoglobin, g/dL†  9.8∥  8.5∥  8.7∥  7.5∥  9.5∥ 
Hematocrit, %   29.8∥  26.6∥  25.8∥  22.8∥  31.0∥ 
Platelets/mm3‡  5000∥  7000∥  13 000∥  16 000∥  11 000∥ 
Chemistry      
Albumin, g/dL†  2.4   2.2   2.8   3.4   2.3  
Total bilirubin, mg/dL§  1.2   4.8   2.1   1.3   13.6  
Direct bilirubin, mg/dL§  0.5   2.8   1.1   0.7   7.5  
LDH, U/L   552   769   239   227   595  
Mastocytosis-related findings      
Serum histamine, ng/dL   ND   6910   1031   779   2525  
Serum tryptase, μg/L
 		 > 200
 		 > 200
 		 > 200
 		 > 200
 		 > 200
 
Initial Presentation
Pretreatment
Cycle 1
Cycle 2
Cycle 3/Relapse
Date   Apr 2003   Jun 2003   Jun-Jul 2003   Jul-Aug 2003   Aug-Sep 2003  
Hematology      
WBCs/mm3*  15.8   8.4   8.0   7.9   12.2  
Differential count, %       
Segmented neutrophils   14   19   46   44   20  
Bands   10   6   29   26   7  
Lymphocytes   19   19   11   17   7  
Monocytes   8   5   7   8   0  
Eosinophils   0   2   0   1   0  
Basophils   0   0   0   0   0  
Immature myeloids   31   3   2   4   51  
Blasts   5   0   0   0   8  
Mast cells   11   46   5   0   2  
Nucleated red blood cells/100 WBCs   7   47   4   4   0  
Hemoglobin, g/dL†  9.8∥  8.5∥  8.7∥  7.5∥  9.5∥ 
Hematocrit, %   29.8∥  26.6∥  25.8∥  22.8∥  31.0∥ 
Platelets/mm3‡  5000∥  7000∥  13 000∥  16 000∥  11 000∥ 
Chemistry      
Albumin, g/dL†  2.4   2.2   2.8   3.4   2.3  
Total bilirubin, mg/dL§  1.2   4.8   2.1   1.3   13.6  
Direct bilirubin, mg/dL§  0.5   2.8   1.1   0.7   7.5  
LDH, U/L   552   769   239   227   595  
Mastocytosis-related findings      
Serum histamine, ng/dL   ND   6910   1031   779   2525  
Serum tryptase, μg/L
 		 > 200
 		 > 200
 		 > 200
 		 > 200
 		 > 200
 

WBCs indicates white blood cells; LDH, lactate dehydrogenase.

*

To convert to × 109 cells per liter, multiply by 1.

†

To convert to grams per liter, multiply by 10.

‡

To convert to × 109 platelets per liter, divide by 1000.

§

To convert to micromoles per liter, multiply by 17.1.

∥

Transfusion-dependent.

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