Estimated time from first appearance until various levels of neoplastic HSCs were reached in simulations in which the neoplastic clone eventually dominated
. | Mouse . | . | Cat . | . | ||
|---|---|---|---|---|---|---|
| % of total . | Mean time, y . | 95% CI . | Mean time, y . | 95% CI . | ||
| 1 | 1.1 | 0.2, 2.0 | 3.2 | 1.0, 5.5 | ||
| 10 | 1.9 | 1.0, 2.9 | 5.5 | 3.2, 7.8 | ||
| 25 | 2.2 | 1.3, 3.2 | 6.4 | 4.0, 8.7 | ||
| 50 | 2.5 | 1.5, 3.4 | 7.1 | 4.7, 9.4 | ||
| 95 | 2.7 | 1.8, 3.7 | 7.8 | 5.4, 10.1 | ||
| 100 | 3.1 | 2.2, 4.1 | 9.1 | 6.7, 11.4 | ||
. | Mouse . | . | Cat . | . | ||
|---|---|---|---|---|---|---|
| % of total . | Mean time, y . | 95% CI . | Mean time, y . | 95% CI . | ||
| 1 | 1.1 | 0.2, 2.0 | 3.2 | 1.0, 5.5 | ||
| 10 | 1.9 | 1.0, 2.9 | 5.5 | 3.2, 7.8 | ||
| 25 | 2.2 | 1.3, 3.2 | 6.4 | 4.0, 8.7 | ||
| 50 | 2.5 | 1.5, 3.4 | 7.1 | 4.7, 9.4 | ||
| 95 | 2.7 | 1.8, 3.7 | 7.8 | 5.4, 10.1 | ||
| 100 | 3.1 | 2.2, 4.1 | 9.1 | 6.7, 11.4 | ||
Neoplastic clone domination was defined as greater than 50% neoplastic cells.