Patient characteristics, clinical presentation, and laboratory data
Patient no. . | Age, y . | Main clinical presentation . | Diagnosis . | Additional diagnosis . | TCR gamma rearrangement by PCR . | HLA-A . | HLA-B . | HLA-C . | DR . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 25 | Pan | LGL | — | Y | 26, 32 | 27, 44 | ND | 1, 4 |
| 2 | 72 | Pan | LGL | RA/PNH | Y | 2, 3 | 13, 35 | 4, 8 | 11, 13 |
| 3 | 58 | RCA/Neu | LGL | — | Y | 2, 2 | 58, 55 | ND | 1, 4 |
| 4 | 76 | RCA | LGL | — | Y | 2, 68 | 27, 51 | ND | 1, 13 |
| 5 | 62 | Neu | LGL | RA | Y | 1, 2 | 14, 51 | 2, 8 | 1, 13 |
| 6 | 66 | Neu | LGL | — | Y | NA | NA | NA | NA |
| 7 | 61 | Neu | LGL | — | Y | 3, 24 | 37, 40 | 3, 6 | 4, 10 |
| 8 | 36 | Neu | LGL | — | Y | 2, 11 | 18, 44 | 7, 16 | 11, 13 |
| 9 | 58 | Neu | LGL | MS | Y | 1, 32 | 8, 44 | 5, 7 | 4, 15 |
| 10 | 65 | Pan | LGL | — | Y | 1, 68 | 14, 37 | 6, 8 | 15, 13 |
| 11 | 42 | RCA | LGL | Hepatitis | Y | 1, 2 | 7, 37 | 6, 7 | N.D. |
| 12 | 61 | Neu | LGL | RhAr | Y | 1, 2 | 8, 15 | 3, 7 | 3, 4 |
| 13 | 63 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 14 | 77 | RCA | LGL | — | Y | ND | ND | ND | ND |
| 15 | 37 | Neu | LGL | SLE | N | ND | ND | ND | ND |
| 16 | 50 | RCA | LGL | — | Y | ND | ND | ND | ND |
| 17 | 64 | Pan | LGL | RARS | Y | 29, 08 | 40, 45 | ND | 11, 15 |
| 18 | 63 | RCA | LGL | UC | Y | 2, 2 | 8, 44 | 7, 7 | 3, 11 |
| 19 | 65 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 20 | 78 | RCA | LGL | RhAr | Y | ND | ND | ND | ND |
| 21 | 51 | Neu | LGL | — | Y | 2, 24 | 7, 73 | 7, 15 | 1, 4 |
| 22 | 76 | Pan | LGL | RA | Y | 24, 24 | 7, 35 | 4, 7 | 1, NA |
| 23 | 80 | RCA | LGL | RA | Y | 1, 29 | 13, 44 | 6, 16 | 4, 7 |
| 24 | 32 | Pan | LGL | Hepatitis | Y | 2, 24 | 40, 51 | 3, 3 | 4, 12 |
| 25 | 63 | RCA | LGL | RA | Y | 11, 33 | 51, 65 | 7, 8 | 1, 13 |
| 26 | 73 | Neu | LGL | RhAr | Y | 2, 29 | 44, 44 | 12, 16 | 4, 4 |
| 27 | 62 | Neu | LGL | Hepatitis | Y | 2, 2 | 7, 51 | 1, 7 | 11, 4 |
| 28 | 46 | Neu | LGL | RhAr | Y | 3, 24 | 37, 40 | 3, 6 | 4, 10 |
| 29 | 62 | Neu | LGL | — | Y | 23, 32 | 18, 35 | 4, 12 | 1, 13 |
| 30 | 78 | Neu | LGL | — | NA | ND | ND | ND | ND |
| 31 | 71 | RCA | LGL | — | Y | ND | ND | ND | ND |
| 32 | 57 | — | LGL | — | Y | ND | ND | ND | ND |
| 33 | 72 | RCA | LGL | — | Y | 1, 31 | 8, 39 | 7, 7 | 1, 3 |
| 34 | 71 | Neu | LGL | — | Y | 1, 2 | 8, 44 | 7, 7 | 16, 3 |
| 35 | 66 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 36 | 80 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 37 | 62 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 38 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 39 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 40 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 41 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 42 | 64 | RCA | LGL | AIHA | Y | ND | ND | ND | ND |
| 43 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 44 | 77 | Neu | LGL | RA | Y | ND | ND | ND | ND |
| 45 | 76 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 46 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 47 | 59 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 48 | NA | Neu | LGL | — | N | 3, 31 | 18, 51 | 12, 14 | 10, 15 |
| 49 | 70 | Neu | LGL | — | NA | ND | ND | ND | ND |
| 50 | 65 | Neu | AIN | — | N | 2, 11 | 7, 15 | 3, 7 | 15, 4 |
| 51 | 72 | Pan | LGL | RA | N | 1, 68 | 35, 44 | 4, 4 | 7, 8 |
| 52 | 51 | Neu | LGL | — | N | 11, 26 | 45, 51 | 3, 6 | 4, 9 |
| 53 | 29 | Neu | AIN | Hepatitis | N | ND | ND | ND | ND |
| 54 | 43 | Neu | AIN | Hepatitis | N | 3, 3 | 7, 35 | 4, 7 | 1, 15 |
| 55 | 64 | Neu | LGL | RhAr | Y | 24, 02 | 44, 51 | 2, 4 | 11, 13 |
| 56 | 39 | Pan | AIN | — | Y | 2, NA | 15, 44 | 3, 5 | 4, 13 |
| 57 | 56 | Neu | LGL | RhAr | Y | 1, 25 | 8, 18 | 7, 12 | 4, 11 |
| 58 | 60 | Pan | LGL | PNH | NA | 68, 68 | 14, 14 | 8, 8 | 1, 1 |
| 59 | 53 | Neu | LGL | AIH | Y | 1, 3 | 7, 37 | 6, 7 | 13, 15 |
| 60 | 51 | Pan | LGL | — | N | 11, 24 | 27, 22 | 1, 1 | 4, 15 |
Patient no. . | Age, y . | Main clinical presentation . | Diagnosis . | Additional diagnosis . | TCR gamma rearrangement by PCR . | HLA-A . | HLA-B . | HLA-C . | DR . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 25 | Pan | LGL | — | Y | 26, 32 | 27, 44 | ND | 1, 4 |
| 2 | 72 | Pan | LGL | RA/PNH | Y | 2, 3 | 13, 35 | 4, 8 | 11, 13 |
| 3 | 58 | RCA/Neu | LGL | — | Y | 2, 2 | 58, 55 | ND | 1, 4 |
| 4 | 76 | RCA | LGL | — | Y | 2, 68 | 27, 51 | ND | 1, 13 |
| 5 | 62 | Neu | LGL | RA | Y | 1, 2 | 14, 51 | 2, 8 | 1, 13 |
| 6 | 66 | Neu | LGL | — | Y | NA | NA | NA | NA |
| 7 | 61 | Neu | LGL | — | Y | 3, 24 | 37, 40 | 3, 6 | 4, 10 |
| 8 | 36 | Neu | LGL | — | Y | 2, 11 | 18, 44 | 7, 16 | 11, 13 |
| 9 | 58 | Neu | LGL | MS | Y | 1, 32 | 8, 44 | 5, 7 | 4, 15 |
| 10 | 65 | Pan | LGL | — | Y | 1, 68 | 14, 37 | 6, 8 | 15, 13 |
| 11 | 42 | RCA | LGL | Hepatitis | Y | 1, 2 | 7, 37 | 6, 7 | N.D. |
| 12 | 61 | Neu | LGL | RhAr | Y | 1, 2 | 8, 15 | 3, 7 | 3, 4 |
| 13 | 63 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 14 | 77 | RCA | LGL | — | Y | ND | ND | ND | ND |
| 15 | 37 | Neu | LGL | SLE | N | ND | ND | ND | ND |
| 16 | 50 | RCA | LGL | — | Y | ND | ND | ND | ND |
| 17 | 64 | Pan | LGL | RARS | Y | 29, 08 | 40, 45 | ND | 11, 15 |
| 18 | 63 | RCA | LGL | UC | Y | 2, 2 | 8, 44 | 7, 7 | 3, 11 |
| 19 | 65 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 20 | 78 | RCA | LGL | RhAr | Y | ND | ND | ND | ND |
| 21 | 51 | Neu | LGL | — | Y | 2, 24 | 7, 73 | 7, 15 | 1, 4 |
| 22 | 76 | Pan | LGL | RA | Y | 24, 24 | 7, 35 | 4, 7 | 1, NA |
| 23 | 80 | RCA | LGL | RA | Y | 1, 29 | 13, 44 | 6, 16 | 4, 7 |
| 24 | 32 | Pan | LGL | Hepatitis | Y | 2, 24 | 40, 51 | 3, 3 | 4, 12 |
| 25 | 63 | RCA | LGL | RA | Y | 11, 33 | 51, 65 | 7, 8 | 1, 13 |
| 26 | 73 | Neu | LGL | RhAr | Y | 2, 29 | 44, 44 | 12, 16 | 4, 4 |
| 27 | 62 | Neu | LGL | Hepatitis | Y | 2, 2 | 7, 51 | 1, 7 | 11, 4 |
| 28 | 46 | Neu | LGL | RhAr | Y | 3, 24 | 37, 40 | 3, 6 | 4, 10 |
| 29 | 62 | Neu | LGL | — | Y | 23, 32 | 18, 35 | 4, 12 | 1, 13 |
| 30 | 78 | Neu | LGL | — | NA | ND | ND | ND | ND |
| 31 | 71 | RCA | LGL | — | Y | ND | ND | ND | ND |
| 32 | 57 | — | LGL | — | Y | ND | ND | ND | ND |
| 33 | 72 | RCA | LGL | — | Y | 1, 31 | 8, 39 | 7, 7 | 1, 3 |
| 34 | 71 | Neu | LGL | — | Y | 1, 2 | 8, 44 | 7, 7 | 16, 3 |
| 35 | 66 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 36 | 80 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 37 | 62 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 38 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 39 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 40 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 41 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 42 | 64 | RCA | LGL | AIHA | Y | ND | ND | ND | ND |
| 43 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 44 | 77 | Neu | LGL | RA | Y | ND | ND | ND | ND |
| 45 | 76 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 46 | NA | Neu | LGL | — | Y | ND | ND | ND | ND |
| 47 | 59 | Neu | LGL | — | Y | ND | ND | ND | ND |
| 48 | NA | Neu | LGL | — | N | 3, 31 | 18, 51 | 12, 14 | 10, 15 |
| 49 | 70 | Neu | LGL | — | NA | ND | ND | ND | ND |
| 50 | 65 | Neu | AIN | — | N | 2, 11 | 7, 15 | 3, 7 | 15, 4 |
| 51 | 72 | Pan | LGL | RA | N | 1, 68 | 35, 44 | 4, 4 | 7, 8 |
| 52 | 51 | Neu | LGL | — | N | 11, 26 | 45, 51 | 3, 6 | 4, 9 |
| 53 | 29 | Neu | AIN | Hepatitis | N | ND | ND | ND | ND |
| 54 | 43 | Neu | AIN | Hepatitis | N | 3, 3 | 7, 35 | 4, 7 | 1, 15 |
| 55 | 64 | Neu | LGL | RhAr | Y | 24, 02 | 44, 51 | 2, 4 | 11, 13 |
| 56 | 39 | Pan | AIN | — | Y | 2, NA | 15, 44 | 3, 5 | 4, 13 |
| 57 | 56 | Neu | LGL | RhAr | Y | 1, 25 | 8, 18 | 7, 12 | 4, 11 |
| 58 | 60 | Pan | LGL | PNH | NA | 68, 68 | 14, 14 | 8, 8 | 1, 1 |
| 59 | 53 | Neu | LGL | AIH | Y | 1, 3 | 7, 37 | 6, 7 | 13, 15 |
| 60 | 51 | Pan | LGL | — | N | 11, 24 | 27, 22 | 1, 1 | 4, 15 |
Pan indicates pancytopenia; LGL, large granular lymphocyte leukemia; —, not applicable; Y, yes; ND, not done; RA, refractory anemia; PNH, paroxysmal nocturnal hemoglobinuria; RCA, red cell aplasia; Neu, neutropenia; NA, not available; MS, multiple sclerosis; RhAr, rheumatoid arthritis; SLE, systemic lupus erythematodus; N, no; RARS, RA with ringed sideroblasts; UC, ulcerative colitis; AIHA, autoimmune hemolytic anemia; and AIN, autoimmune neutropenia.