Identical clonotypes in LGL and other conditions
Patient . | Diagnosis . | VB-JB . | CDR3 . | % clonal frequency . |
|---|---|---|---|---|
| 27 | LGL | VB13-JB2.7 | ASSVPGGEQYF | Minor |
| 50 | LGL | VB13-JB2.7 | ASSVPGGEQYF | 48 |
| 54 | LGL | VB13-JB2.7 | ASSVPGGEQYF | 43 |
| 409 | HD | VB13-JB2.7 | ASSVPGGEQYF | Minor |
| 418 | HD | VB13-JB2.7 | ASSVPGGEQYF | Minor |
| 27 | LGL | VB18-JB2.3 | ASSAVGGTDTQYF | Minor |
| 142 | AHSCT | VB18-JB2.3 | ASSAVGGTDTQYF | 40 |
| 573 | AHSCT | VB18-JB2.3 | ASSAVGGTDTQYF | 25 |
| 217 | AHSCT | VB17-JB2.3 | ASSIAVRLASTDTQYF | 30 |
| 4 | LGL | VB17-JB2.3 | ASSIAVRLASTDTQYF | 94 |
| McFarland et al73 | HIV-1 | VB13-JB1.2 | ASSPITGTGSYGYTF | 7 |
| 27 | LGL | VB13-JB1.2 | ASSPITGTGSYGYTF | Minor |
| Beck et al74 | GvHD | VB13-JB2.2 | ASSSETSGRNTGELFF | 25 |
| 27 | LGL | VB13-JB2.2 | ASSSETSGRNTGELFF | Minor |
| 27 | LGL | VB13-JB2.7 | ASSYGQEHYEQYF | Minor |
| 419 | HD | VB13-JB2.7 | ASSYGQEHYEQYF | Minor |
| 418 | HD | VB13-JB2.1 | ASSYSGSHNEQFF | Minor |
| 54 | LGL | VB13-JB2.1 | ASSYSGSHNEQFF | 21 |
| 258 | AHSCT | VB15-JB2.5 | ATSDLTWGETQY | 25 |
| 574 | AHSCT | VB15-JB2.5 | ATSDLTWGETQY | 60 |
| 242 | AHSCT | VB15-JB2.5 | ATSDLTWGETQY | 27 |
| 32 | LGL | VB15-JB2.5 | ATSDLTWGETQY | 26 |
Patient . | Diagnosis . | VB-JB . | CDR3 . | % clonal frequency . |
|---|---|---|---|---|
| 27 | LGL | VB13-JB2.7 | ASSVPGGEQYF | Minor |
| 50 | LGL | VB13-JB2.7 | ASSVPGGEQYF | 48 |
| 54 | LGL | VB13-JB2.7 | ASSVPGGEQYF | 43 |
| 409 | HD | VB13-JB2.7 | ASSVPGGEQYF | Minor |
| 418 | HD | VB13-JB2.7 | ASSVPGGEQYF | Minor |
| 27 | LGL | VB18-JB2.3 | ASSAVGGTDTQYF | Minor |
| 142 | AHSCT | VB18-JB2.3 | ASSAVGGTDTQYF | 40 |
| 573 | AHSCT | VB18-JB2.3 | ASSAVGGTDTQYF | 25 |
| 217 | AHSCT | VB17-JB2.3 | ASSIAVRLASTDTQYF | 30 |
| 4 | LGL | VB17-JB2.3 | ASSIAVRLASTDTQYF | 94 |
| McFarland et al73 | HIV-1 | VB13-JB1.2 | ASSPITGTGSYGYTF | 7 |
| 27 | LGL | VB13-JB1.2 | ASSPITGTGSYGYTF | Minor |
| Beck et al74 | GvHD | VB13-JB2.2 | ASSSETSGRNTGELFF | 25 |
| 27 | LGL | VB13-JB2.2 | ASSSETSGRNTGELFF | Minor |
| 27 | LGL | VB13-JB2.7 | ASSYGQEHYEQYF | Minor |
| 419 | HD | VB13-JB2.7 | ASSYGQEHYEQYF | Minor |
| 418 | HD | VB13-JB2.1 | ASSYSGSHNEQFF | Minor |
| 54 | LGL | VB13-JB2.1 | ASSYSGSHNEQFF | 21 |
| 258 | AHSCT | VB15-JB2.5 | ATSDLTWGETQY | 25 |
| 574 | AHSCT | VB15-JB2.5 | ATSDLTWGETQY | 60 |
| 242 | AHSCT | VB15-JB2.5 | ATSDLTWGETQY | 27 |
| 32 | LGL | VB15-JB2.5 | ATSDLTWGETQY | 26 |
VB-JB indicates restriction of the variable beta and joining beta region of the TCR; LGL, large granular lymphocytic leukemia; minor, nonexpanded clonotype; HD, healthy donor; AHSCT, allogeneic hematopoietic stem cell transplantation; and GvHD, graft-versus-host disease.