Examples of a comparison of LGL-associated clonotypes based on the physicochemical AA properties (7-AA substitution)
Patient . | VB-JB . | CDR3/20AA code . | . | CDR3/7AA substitution . | . | ||
|---|---|---|---|---|---|---|---|
| 7 | VB6-JB2.1 | ASS-LASI | -SYNEQFF | BUU-BBUB | -UJZZZJJ | ||
| 41 | VB24-JB2.5 | ATS-LGTL | -QETQYF | BUU-BBUB | -ZZUZJJ | ||
| 8 | VB23-JB1.1 | ASS-LGNR | -EVAFF | BUU-BBZX | -ZBBJJ | ||
| 52 | VB1-JB1.1 | ASS-AGQD | -TEAFF | BUU-BBZZ | -UZBJJBZ | ||
| 58 | VB13-JB1.5 | ASS-YGGG | -QPQHFGD | BUU-JBBB | -ZPZXJ | ||
| 55 | VB13-JB2.3 | ASS-YVGV | -DTQYF | BUU-JBBB | -ZUZJJ | ||
| 18 | VB3-JB2.1 | ASS-PLGAGV | -YNEQFF | BUU-PBBBBB | -JZZZJJ | ||
| 27 | VB18-JB2.7 | ASS-PAGGSG | -SYEQYF | BUU-PBBBUB | -UJZZJJ | ||
| 46 | VB17-JB2.1 | ASS-TFG | -EQFF | BUU-UJB | -ZZJJ | ||
| 44 | VB21-JB1.1 | ASS-SY | -NEAFF | BUU-UJ | -ZZBJJ | ||
| 14 | VB2-JB2.7 | SAS-GLLAGGA | -SYEQYF | UBU-BBBBBBB | -UJZZJJ | ||
| 24 | VB2-JB2.7 | SAS-FLTGLAG | -EQYF | UBU-JBUBBBB | -ZZJJ | ||
Patient . | VB-JB . | CDR3/20AA code . | . | CDR3/7AA substitution . | . | ||
|---|---|---|---|---|---|---|---|
| 7 | VB6-JB2.1 | ASS-LASI | -SYNEQFF | BUU-BBUB | -UJZZZJJ | ||
| 41 | VB24-JB2.5 | ATS-LGTL | -QETQYF | BUU-BBUB | -ZZUZJJ | ||
| 8 | VB23-JB1.1 | ASS-LGNR | -EVAFF | BUU-BBZX | -ZBBJJ | ||
| 52 | VB1-JB1.1 | ASS-AGQD | -TEAFF | BUU-BBZZ | -UZBJJBZ | ||
| 58 | VB13-JB1.5 | ASS-YGGG | -QPQHFGD | BUU-JBBB | -ZPZXJ | ||
| 55 | VB13-JB2.3 | ASS-YVGV | -DTQYF | BUU-JBBB | -ZUZJJ | ||
| 18 | VB3-JB2.1 | ASS-PLGAGV | -YNEQFF | BUU-PBBBBB | -JZZZJJ | ||
| 27 | VB18-JB2.7 | ASS-PAGGSG | -SYEQYF | BUU-PBBBUB | -UJZZJJ | ||
| 46 | VB17-JB2.1 | ASS-TFG | -EQFF | BUU-UJB | -ZZJJ | ||
| 44 | VB21-JB1.1 | ASS-SY | -NEAFF | BUU-UJ | -ZZBJJ | ||
| 14 | VB2-JB2.7 | SAS-GLLAGGA | -SYEQYF | UBU-BBBBBBB | -UJZZJJ | ||
| 24 | VB2-JB2.7 | SAS-FLTGLAG | -EQYF | UBU-JBUBBBB | -ZZJJ | ||
A redundant classification scheme was applied for the comparison of the TCR-CDR3 region, based on the structural, chemical, charge, and functional properties of the amino acids. For substitution code, see “Sequence analysis.”
VB-JB indicates VB and JB regions used by the immunodominant clonotype; CDR3/20AA code and CDR3/7AA, CDR3 region sequence in 20-AA and 7-AA code, respectively; and Jun, invariant amino acids of the JB region. Italic amino acids indicate the beginning of the JB region and include the invariant JB-specific amino acids. Underlined type indicates AA differences.