Clinical characteristics of the patients and controls involved in the study
Sample . | Age, y . | Sex . | Hb level, g/dL . | MCV, fL . | WBC, × 109/L . | Neuts, × 109/L . | Lymphs, × 109/L . | PLTs, × 109/L . | BM blast, % . | BM karyotype . | Diagnosis . | Use . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N1 | 67 | F | 12.9 | 91 | 5.5 | 2.7 | 2.2 | 261 | <1 | Not tested | Normal | MA, QTPCR |
| N2 | 62 | M | 14.4 | 94 | 8.1 | 5.2 | 2.2 | 402 | <1 | Not tested | Normal | MA, QTPCR |
| N3 | 56 | M | 14.9 | 91 | 8.8 | 5.9 | 2.1 | 274 | <1 | Not tested | Normal | MA, QTPCR |
| N4 | 58 | M | 15.5 | 85 | 5.8 | 3.1 | 1.9 | 164 | <1 | Not tested | Normal | MA, QTPCR |
| N5 | 70 | F | 13.5 | 102 | 7.5 | 4.0 | 2.4 | 379 | <1 | Not tested | Normal | MA, QTPCR |
| N6 | 41 | M | 13.6 | 92 | 7.5 | 3.3 | 2.9 | 303 | <1 | Not tested | Normal | MA, QTPCR |
| N7 | 78 | F | 12.4 | 93 | 5.0 | 3.1 | 1.2 | 310 | <1 | Not tested | Normal | MA, QTPCR |
| N8 | 64 | F | 14.2 | 95 | 5.5 | 3.2 | 1.5 | 230 | <1 | Not tested | Normal | MA, QTPCR |
| N9 | 60 | F | 14.0 | 87 | 6.8 | 4.6 | 1.7 | 272 | <1 | Not tested | Normal | MA, QTPCR |
| N10 | 68 | F | 13.6 | 102 | 4.8 | 2.9 | 1.3 | 172 | <1 | Not tested | Normal | FCM |
| N11 | 67 | M | 14.8 | 88 | 9.6 | 6.9 | 1.7 | 235 | <1 | Not tested | Normal | FCM |
| N12 | 69 | M | 14.1 | 96 | 8.1 | 5.0 | 2.1 | 290 | <1 | Not tested | Normal | FCM |
| N13 | 70 | F | 14.0 | 89 | 6.6 | 3.5 | 2.4 | 266 | <1 | Not tested | Normal | FCM |
| N14 | 84 | F | 12.8 | 92 | 6.4 | 4.4 | 1.7 | 257 | <1 | Not tested | Normal | FCM |
| N15 | 61 | M | 12.8 | 90 | 6.9 | 4.1 | 2.2 | 321 | <1 | Not tested | Normal | FCM |
| MDS1 | 65 | M | 14.2 | 92 | 3.2 | 0.8 | 2.1 | 151 | 2 | 46, XY | RCMD | MA, QTPCR |
| MDS2 | 89 | F | 8.7 | 79 | 14.0 | 7.2 | 5.5 | 213 | <1 | 46, XX | RCMD | MA, QTPCR |
| MDS3 | 83 | M | 13.4 | 108 | 4.5 | 2.4 | 1.5 | 148 | 2 | 46, XY | RCMD-RS | MA, QTPCR |
| MDS4 | 79 | M | 5.1 | 92 | 4.6 | 2.3 | 1.5 | 142 | <1 | 46, XY | RCMD | MA, QTPCR |
| MDS5 | 81 | M | 10.1 | 101 | 4.1 | 1.9 | 2.0 | 115 | <1 | 46, XY | RCMD | MA, QTPCR |
| MDS6 | 42 | M | 8.4 | 99 | 6.2 | 2.4 | 3.0 | 111 | <1 | 46, XY | RCMD | MA, QTPCR |
| MDS7 | 63 | F | 11.5 | 120 | 6.9 | 1.5 | 3.1 | 122 | 1 | 46, XX | RCMD-RS | MA, QTPCR |
| MDS8 | 82 | F | 9.3 | 96 | 5.4 | 2.2 | 1.3 | 531 | 3 | 46, XX | RCMD | MA, QTPCR |
| MDS9 | 82 | F | 9.4 | 120 | 6.3 | 3.1 | 2.0 | 299 | <1 | 46, XX | RCMD | MA, QTPCR |
| MDS10 | 77 | F | 11.5 | 107 | 2.1 | 1.6 | 0.2 | 23 | 2 | 46, XX | RCMD | MA, QTPCR |
| MDS11 | 90 | M | 6.9 | 127 | 3.5 | 1.5 | 1.4 | 65 | 3 | 46, XY | RCMD | MA, QTPCR |
| MDS12 | 59 | M | 9.9 | 90 | 6.9 | 4.8 | 0.8 | 99 | 2 | 46, XY | RCMD | MA, QTPCR |
| MDS13 | 89 | M | 11.4 | 98 | 6.7 | 4.5 | 1.2 | 275 | <1 | 46, XY | RCMD | MA, QTPCR |
| MDS14 | 81 | F | 8.5 | 103 | 10.6 | 8.7 | 0.8 | 346 | <1 | 46, XX | RA | MA, QTPCR |
| MDS15 | 29 | F | 12.6 | 108 | 3.2 | 1.5 | 1.4 | 91 | <1 | 46, XX | RCMD | QTPCR |
| MDS16 | 78 | M | 12.3 | 86.4 | 2.4 | 0.9 | 0.9 | 133 | <1 | 46, XY | RCMD | QTPCR |
| MDS17 | 51 | M | 12.7 | 86 | 3.7 | 1.6 | 1.7 | 120 | <1 | 46, XY | RCMD | QTPCR |
| MDS18 | 82 | M | 9.9 | 102 | 3.9 | 1.4 | 1.6 | 246 | <1 | 46, XY | RCMD | QTPCR |
| MDS19 | 59 | F | 8.9 | 86.9 | 5.6 | 4.4 | 1.0 | 153 | <1 | 46, XX | RCMD | QTPCR |
| MDS20 | 84 | F | 8.0 | 106 | 2.9 | 1.0 | 0.9 | 251 | <1 | 46, XX | RCMD-RS | QTPCR |
| MDS21 | 69 | F | 10.6 | 90 | 5.8 | 4.1 | 1.3 | 109 | 2 | 46, XX | RCMD | QTPCR |
| MDS22 | 47 | F | 10.8 | 87 | 6.3 | 3.5 | 2.2 | 108 | <1 | 46, XX | RCMD | QTPCR |
| MDS23 | 89 | M | 11.9 | 92 | 4.9 | 2.5 | 1.6 | 82 | <1 | 46, XY | RCMD | QTPCR |
| MDS24 | 70 | M | 11.1 | 96.5 | 11.61 | 9.95 | 0.9 | 123 | <1 | 45X-Y(4), 46XY(16) | RCMD | FCM |
| MDS25 | 76 | M | 14.8 | 97.3 | 2.39 | 2.39 | 1.8 | 86 | 4 | 46, XY | RCMD | FCM |
| MDS26 | 66 | M | 11.5 | 107 | 6.3 | 4.1 | 1.7 | 172 | <1 | 45X-Y(3), 46XY(17) | RA | FCM |
| MDS27 | 50 | M | 10.6 | 97 | 4.8 | 3.5 | 1.3 | 180 | <1 | 46, XY | RCMD | FCM |
| MDS28 | 69 | F | 11.5 | 90 | 4.6 | 3.8 | 1.3 | 130 | <1 | 46, XX | RCMD | FCM |
| MDS29 | 82 | M | 9.5 | 81 | 8.5 | 5.8 | 1.4 | 453 | 2 | 46, XY | RCMD-RS | FCM |
| MDS30 | 73 | M | 8.2 | 92 | 13.0 | 5.5 | 3.9 | 197 | <1 | 46, XY | RCMD | FCM |
| Folate def | 84 | F | 8.5 | 127 | 4.8 | 3.2 | 1.1 | 172 | <1 | 46, XX | Folate def | MA, QTPCR |
| B12 def | 87 | M | 7.1 | 118 | 1.5 | 0.75 | 0.2 | 57 | <1 | 46, XY | B12 def | MA, QTPCR |
| RhA1* | 69 | F | 10.4 | 102 | 6.2 | 4.8 | 0.9 | 159 | <1 | 46, XX | ACI | MA, QTPCR |
| RhA2† | 82 | F | 10.9 | 97 | 8.9 | 6.4 | 1.6 | 408 | <1 | 46, XX | ACI | MA, QTPCR |
| RhA3† | 51 | F | 9.0 | 81 | 10.5 | 7.9 | 1.5 | 895 | <1 | 46, XX | ACI | MA, QTPCR |
Sample . | Age, y . | Sex . | Hb level, g/dL . | MCV, fL . | WBC, × 109/L . | Neuts, × 109/L . | Lymphs, × 109/L . | PLTs, × 109/L . | BM blast, % . | BM karyotype . | Diagnosis . | Use . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N1 | 67 | F | 12.9 | 91 | 5.5 | 2.7 | 2.2 | 261 | <1 | Not tested | Normal | MA, QTPCR |
| N2 | 62 | M | 14.4 | 94 | 8.1 | 5.2 | 2.2 | 402 | <1 | Not tested | Normal | MA, QTPCR |
| N3 | 56 | M | 14.9 | 91 | 8.8 | 5.9 | 2.1 | 274 | <1 | Not tested | Normal | MA, QTPCR |
| N4 | 58 | M | 15.5 | 85 | 5.8 | 3.1 | 1.9 | 164 | <1 | Not tested | Normal | MA, QTPCR |
| N5 | 70 | F | 13.5 | 102 | 7.5 | 4.0 | 2.4 | 379 | <1 | Not tested | Normal | MA, QTPCR |
| N6 | 41 | M | 13.6 | 92 | 7.5 | 3.3 | 2.9 | 303 | <1 | Not tested | Normal | MA, QTPCR |
| N7 | 78 | F | 12.4 | 93 | 5.0 | 3.1 | 1.2 | 310 | <1 | Not tested | Normal | MA, QTPCR |
| N8 | 64 | F | 14.2 | 95 | 5.5 | 3.2 | 1.5 | 230 | <1 | Not tested | Normal | MA, QTPCR |
| N9 | 60 | F | 14.0 | 87 | 6.8 | 4.6 | 1.7 | 272 | <1 | Not tested | Normal | MA, QTPCR |
| N10 | 68 | F | 13.6 | 102 | 4.8 | 2.9 | 1.3 | 172 | <1 | Not tested | Normal | FCM |
| N11 | 67 | M | 14.8 | 88 | 9.6 | 6.9 | 1.7 | 235 | <1 | Not tested | Normal | FCM |
| N12 | 69 | M | 14.1 | 96 | 8.1 | 5.0 | 2.1 | 290 | <1 | Not tested | Normal | FCM |
| N13 | 70 | F | 14.0 | 89 | 6.6 | 3.5 | 2.4 | 266 | <1 | Not tested | Normal | FCM |
| N14 | 84 | F | 12.8 | 92 | 6.4 | 4.4 | 1.7 | 257 | <1 | Not tested | Normal | FCM |
| N15 | 61 | M | 12.8 | 90 | 6.9 | 4.1 | 2.2 | 321 | <1 | Not tested | Normal | FCM |
| MDS1 | 65 | M | 14.2 | 92 | 3.2 | 0.8 | 2.1 | 151 | 2 | 46, XY | RCMD | MA, QTPCR |
| MDS2 | 89 | F | 8.7 | 79 | 14.0 | 7.2 | 5.5 | 213 | <1 | 46, XX | RCMD | MA, QTPCR |
| MDS3 | 83 | M | 13.4 | 108 | 4.5 | 2.4 | 1.5 | 148 | 2 | 46, XY | RCMD-RS | MA, QTPCR |
| MDS4 | 79 | M | 5.1 | 92 | 4.6 | 2.3 | 1.5 | 142 | <1 | 46, XY | RCMD | MA, QTPCR |
| MDS5 | 81 | M | 10.1 | 101 | 4.1 | 1.9 | 2.0 | 115 | <1 | 46, XY | RCMD | MA, QTPCR |
| MDS6 | 42 | M | 8.4 | 99 | 6.2 | 2.4 | 3.0 | 111 | <1 | 46, XY | RCMD | MA, QTPCR |
| MDS7 | 63 | F | 11.5 | 120 | 6.9 | 1.5 | 3.1 | 122 | 1 | 46, XX | RCMD-RS | MA, QTPCR |
| MDS8 | 82 | F | 9.3 | 96 | 5.4 | 2.2 | 1.3 | 531 | 3 | 46, XX | RCMD | MA, QTPCR |
| MDS9 | 82 | F | 9.4 | 120 | 6.3 | 3.1 | 2.0 | 299 | <1 | 46, XX | RCMD | MA, QTPCR |
| MDS10 | 77 | F | 11.5 | 107 | 2.1 | 1.6 | 0.2 | 23 | 2 | 46, XX | RCMD | MA, QTPCR |
| MDS11 | 90 | M | 6.9 | 127 | 3.5 | 1.5 | 1.4 | 65 | 3 | 46, XY | RCMD | MA, QTPCR |
| MDS12 | 59 | M | 9.9 | 90 | 6.9 | 4.8 | 0.8 | 99 | 2 | 46, XY | RCMD | MA, QTPCR |
| MDS13 | 89 | M | 11.4 | 98 | 6.7 | 4.5 | 1.2 | 275 | <1 | 46, XY | RCMD | MA, QTPCR |
| MDS14 | 81 | F | 8.5 | 103 | 10.6 | 8.7 | 0.8 | 346 | <1 | 46, XX | RA | MA, QTPCR |
| MDS15 | 29 | F | 12.6 | 108 | 3.2 | 1.5 | 1.4 | 91 | <1 | 46, XX | RCMD | QTPCR |
| MDS16 | 78 | M | 12.3 | 86.4 | 2.4 | 0.9 | 0.9 | 133 | <1 | 46, XY | RCMD | QTPCR |
| MDS17 | 51 | M | 12.7 | 86 | 3.7 | 1.6 | 1.7 | 120 | <1 | 46, XY | RCMD | QTPCR |
| MDS18 | 82 | M | 9.9 | 102 | 3.9 | 1.4 | 1.6 | 246 | <1 | 46, XY | RCMD | QTPCR |
| MDS19 | 59 | F | 8.9 | 86.9 | 5.6 | 4.4 | 1.0 | 153 | <1 | 46, XX | RCMD | QTPCR |
| MDS20 | 84 | F | 8.0 | 106 | 2.9 | 1.0 | 0.9 | 251 | <1 | 46, XX | RCMD-RS | QTPCR |
| MDS21 | 69 | F | 10.6 | 90 | 5.8 | 4.1 | 1.3 | 109 | 2 | 46, XX | RCMD | QTPCR |
| MDS22 | 47 | F | 10.8 | 87 | 6.3 | 3.5 | 2.2 | 108 | <1 | 46, XX | RCMD | QTPCR |
| MDS23 | 89 | M | 11.9 | 92 | 4.9 | 2.5 | 1.6 | 82 | <1 | 46, XY | RCMD | QTPCR |
| MDS24 | 70 | M | 11.1 | 96.5 | 11.61 | 9.95 | 0.9 | 123 | <1 | 45X-Y(4), 46XY(16) | RCMD | FCM |
| MDS25 | 76 | M | 14.8 | 97.3 | 2.39 | 2.39 | 1.8 | 86 | 4 | 46, XY | RCMD | FCM |
| MDS26 | 66 | M | 11.5 | 107 | 6.3 | 4.1 | 1.7 | 172 | <1 | 45X-Y(3), 46XY(17) | RA | FCM |
| MDS27 | 50 | M | 10.6 | 97 | 4.8 | 3.5 | 1.3 | 180 | <1 | 46, XY | RCMD | FCM |
| MDS28 | 69 | F | 11.5 | 90 | 4.6 | 3.8 | 1.3 | 130 | <1 | 46, XX | RCMD | FCM |
| MDS29 | 82 | M | 9.5 | 81 | 8.5 | 5.8 | 1.4 | 453 | 2 | 46, XY | RCMD-RS | FCM |
| MDS30 | 73 | M | 8.2 | 92 | 13.0 | 5.5 | 3.9 | 197 | <1 | 46, XY | RCMD | FCM |
| Folate def | 84 | F | 8.5 | 127 | 4.8 | 3.2 | 1.1 | 172 | <1 | 46, XX | Folate def | MA, QTPCR |
| B12 def | 87 | M | 7.1 | 118 | 1.5 | 0.75 | 0.2 | 57 | <1 | 46, XY | B12 def | MA, QTPCR |
| RhA1* | 69 | F | 10.4 | 102 | 6.2 | 4.8 | 0.9 | 159 | <1 | 46, XX | ACI | MA, QTPCR |
| RhA2† | 82 | F | 10.9 | 97 | 8.9 | 6.4 | 1.6 | 408 | <1 | 46, XX | ACI | MA, QTPCR |
| RhA3† | 51 | F | 9.0 | 81 | 10.5 | 7.9 | 1.5 | 895 | <1 | 46, XX | ACI | MA, QTPCR |
Hb indicates hemoglobin; MCV, mean corpuscular volume; WBC, white blood cell count; neuts, neutrophils; lymphs, lymphocytes; PLTs, platelets; BM, bone marrow; N, normal; F, female; MA, microarray; QTPCR, quantitative real-time PCR; M, male; FCM, flow cytometry; MDS, myelodysplastic syndrome; RCMD, refractory cytopenia with multilineage dysplasia; RCMD-RS, refractory cytopenia with multilineage dysplasia with excess ring sideroblasts; RA, refractory anemia; folate def, folate deficiency; B12 def, vitamin B12 deficiency; RhA, rheumatoid arthritis; ACI anemia of chronic inflammation.
Off treatment.
On methotrexate.