Baseline characteristics and clinical data of the 126 patients
. | Weight gain of 2% or less . | Weight gain of more than 2% . | P . |
|---|---|---|---|
| No. patients | 61 | 65 | NA |
| Age, y, median (range) | 53.7 (39.4-68.2) | 54.5 (30.6-70) | .21 |
| Sex, % male | 59.0 | 52.3 | .45 |
| Ejection fraction, %, median (range) | 65 (28-84) | 65 (38-83) | .71 |
| Septal thickness, mm, mean (range) | 12 (7-24) | 12 (8-25) | .52 |
| Elevated troponin T, % | 7.7 | 23.1 | .05 |
| Elevated NT-proBNP, % | 46.2 | 46.7 | .97 |
| GFR, mL/min/1.73m2, median (range) | 76.5 (9-155) | 65 (10-133) | .18 |
| Proteinuria, g/d, median (range) | 3.5 (0.03-18.5) | 5.4 (0.02-26.2) | .01* |
| Albumin, g/dL, median (range) | 3.0 (1.1-4.3) | 2.3 (1.0-4.4) | .03* |
| Alkaline phosphatase, U/L, median (range) | 171 (85-1350) | 186 (67-936) | .3 |
| Organ involvement, kg, median (range) | 1 (1-3) | 2 (1-4) | .002* |
| Baseline weight, median (range) | 79.0 (49-141.2) | 75.0 (43.3-113.1) | .38 |
| Weight change, %, median (range) | 0.16 (-8.4-2.0) | 4.6 (2.1-23.0) | < .001* |
| Weight at conditioning, kg, median (range) | 78.3 (47.6-145) | 78.0 (45.3-113.0) | .86 |
| Diuretic use, % | |||
| Baseline | 37.7 | 60.0 | .012* |
| End of collection | 42.6 | 78.5 | < .001* |
| Change in diuretic dose, % | 9.8 | 43.1 | < .001* |
| Mobilization, % | .60 | ||
| G-CSF | 80.3 | 70.8 | |
| G-CSF + GM-CSF | 1.6 | 4.6 | |
| GM-CSF | 3.3 | 3.1 | |
| Cytoxan + G-CSF | 4.9 | 10.8 | |
| Cytoxan + GM-CSFF | 9.8 | 10.8 | |
| Conditioning, % | .57 | ||
| Melphalan, 200 mg/m2 | 62.3 | 50.8 | |
| Melphalan, 140 mg/m2 | 19.7 | 29.2 | |
| Melphalan, 100 mg/m2 | 8.2 | 9.2 | |
| 140 mg/m2 + TBI | 9.8 | 10.8 |
. | Weight gain of 2% or less . | Weight gain of more than 2% . | P . |
|---|---|---|---|
| No. patients | 61 | 65 | NA |
| Age, y, median (range) | 53.7 (39.4-68.2) | 54.5 (30.6-70) | .21 |
| Sex, % male | 59.0 | 52.3 | .45 |
| Ejection fraction, %, median (range) | 65 (28-84) | 65 (38-83) | .71 |
| Septal thickness, mm, mean (range) | 12 (7-24) | 12 (8-25) | .52 |
| Elevated troponin T, % | 7.7 | 23.1 | .05 |
| Elevated NT-proBNP, % | 46.2 | 46.7 | .97 |
| GFR, mL/min/1.73m2, median (range) | 76.5 (9-155) | 65 (10-133) | .18 |
| Proteinuria, g/d, median (range) | 3.5 (0.03-18.5) | 5.4 (0.02-26.2) | .01* |
| Albumin, g/dL, median (range) | 3.0 (1.1-4.3) | 2.3 (1.0-4.4) | .03* |
| Alkaline phosphatase, U/L, median (range) | 171 (85-1350) | 186 (67-936) | .3 |
| Organ involvement, kg, median (range) | 1 (1-3) | 2 (1-4) | .002* |
| Baseline weight, median (range) | 79.0 (49-141.2) | 75.0 (43.3-113.1) | .38 |
| Weight change, %, median (range) | 0.16 (-8.4-2.0) | 4.6 (2.1-23.0) | < .001* |
| Weight at conditioning, kg, median (range) | 78.3 (47.6-145) | 78.0 (45.3-113.0) | .86 |
| Diuretic use, % | |||
| Baseline | 37.7 | 60.0 | .012* |
| End of collection | 42.6 | 78.5 | < .001* |
| Change in diuretic dose, % | 9.8 | 43.1 | < .001* |
| Mobilization, % | .60 | ||
| G-CSF | 80.3 | 70.8 | |
| G-CSF + GM-CSF | 1.6 | 4.6 | |
| GM-CSF | 3.3 | 3.1 | |
| Cytoxan + G-CSF | 4.9 | 10.8 | |
| Cytoxan + GM-CSFF | 9.8 | 10.8 | |
| Conditioning, % | .57 | ||
| Melphalan, 200 mg/m2 | 62.3 | 50.8 | |
| Melphalan, 140 mg/m2 | 19.7 | 29.2 | |
| Melphalan, 100 mg/m2 | 8.2 | 9.2 | |
| 140 mg/m2 + TBI | 9.8 | 10.8 |
Values in parentheses indicate the range.
TBI indicates total body irradiation; NA, not applicable.
Significant P values.