Treatment-related toxicities
. | No. of patients (%), grades 1 and 2 . | No. of patients (%), grades 3 and 4 . |
|---|---|---|
| Nonhematologic | ||
| Fatigue | 6 (46) | 4 (31) |
| Somnolence | 4 (31) | 0 (0) |
| Constipation | 8 (61) | 0 (0) |
| Neuropathy | 8 (61) | 0 (0) |
| Pulmonary thromboembolism | 0 (0) | 2 (15) |
| Rash | 4 (31) | 0 (0) |
| Flare reaction* | 6 (46) | 0 (0) |
| Pedal edema | 0 (0) | 1 (8) |
| Diarrhea | 0 (0) | 1 (8) |
| Hematologic | ||
| Anemia | 5 (38) | 0 (0) |
| Leukopenia | 0 (0) | 1 (8) |
| Neutropenia | 3 (23) | 1 (8) |
| Thrombocytopenia | 7 (54) | 0 (0) |
. | No. of patients (%), grades 1 and 2 . | No. of patients (%), grades 3 and 4 . |
|---|---|---|
| Nonhematologic | ||
| Fatigue | 6 (46) | 4 (31) |
| Somnolence | 4 (31) | 0 (0) |
| Constipation | 8 (61) | 0 (0) |
| Neuropathy | 8 (61) | 0 (0) |
| Pulmonary thromboembolism | 0 (0) | 2 (15) |
| Rash | 4 (31) | 0 (0) |
| Flare reaction* | 6 (46) | 0 (0) |
| Pedal edema | 0 (0) | 1 (8) |
| Diarrhea | 0 (0) | 1 (8) |
| Hematologic | ||
| Anemia | 5 (38) | 0 (0) |
| Leukopenia | 0 (0) | 1 (8) |
| Neutropenia | 3 (23) | 1 (8) |
| Thrombocytopenia | 7 (54) | 0 (0) |
Tenderness and increased swelling of the involved lymph nodes