Summary of GATA-1 and GATA-3 effects on gene expression in T cells
. | Induction of Th2 genes . | . | . | . | . | Suppression of Th1 genes . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | IL-4 . | IL-5 . | IL-13 . | CCR4 . | CRTH2 . | IFNγ . | CXCR3 . | CCR5 . | ||||||
| GATA-3 | ++++ | ++++ | +++ | +++ | +++++ | + | +/- | +/- | ||||||
| GATA-1 | ++ | +++ | ++ | ++ | ++++ | +++ | ++++ | ++++ | ||||||
. | Induction of Th2 genes . | . | . | . | . | Suppression of Th1 genes . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | IL-4 . | IL-5 . | IL-13 . | CCR4 . | CRTH2 . | IFNγ . | CXCR3 . | CCR5 . | ||||||
| GATA-3 | ++++ | ++++ | +++ | +++ | +++++ | + | +/- | +/- | ||||||
| GATA-1 | ++ | +++ | ++ | ++ | ++++ | +++ | ++++ | ++++ | ||||||
Each + represents a 20% change in T-cell subsets expressing the indicated protein as monitored by flow cytometry compared with HDV-expressing T cells.