Body weights and ratios of organ to body weight in ?/+ and nm/nm animals
. | 4 weeks . | . | . | 8 weeks . | . | . | 12 weeks . | . | . | 24 weeks . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | ?/+, n = 19 . | nm/nm, n = 8 . | P . | ?/+, n = 22 . | nm/nm, n = 10 . | P . | ?/+, n = 13 . | nm/nm, n = 8 . | P . | ?/+, n = 19 . | nm/nm, n = 10 . | P . | ||||||||
| Body weight, g | 17.8 ± 2.4 | 11.7 ± 1.2 | < .001 | 21.4 ± 3.4 | 19.1 ± 2.6 | .050 | 25.9 ± 3.7 | 22.4 ± 3.2 | .243 | 35.9 ± 6.1 | 27.2 ± 3.9 | .002 | ||||||||
| Organ-body weight ratio, mg/g | ||||||||||||||||||||
| Liver | 45.1 ± 3.6 | 54.2 ± 2.1 | < .001 | 43.8 ± 5.3 | 50.7 ± 3.1 | < .001 | 40.7 ± 5.1 | 53.1 ± 5.6 | .001 | 42.8 ± 3.1 | 47.8 ± 2.8 | .001 | ||||||||
| Spleen | 3.8 ± 0.8 | 15.4 ± 3.3 | < .001 | 3.4 ± 1.0 | 7.2 ± 2.2 | < .001 | 3.0 ± 1.2 | 7.7 ± 3.6 | .032 | 2.8 ± 1.2 | 5.0 ± 1.3 | < .001 | ||||||||
| Kidneys | 12.0 ± 1.2 | 13.1 ± 1.0 | .028 | 12.6 ± 1.2 | 12.2 ± 1.5 | .384 | 13.1 ± 1.3 | 13.0 ± 1.2 | .708 | 12.3 ± 2.0 | 12.3 ± 1.4 | .985 | ||||||||
| Testes | 6.9 ± 0.8 | 4.5 ± 0.3 | < .001 | 7.5 ± 0.9 | 5.6 ± 1.5 | .149 | 7.8 ± 0.7 | 6.1 ± 0.7 | .018 | 7.0 ± 1.1 | 6.3 ± 0.8 | .149 | ||||||||
| Thymus | 4.3 ± 1.3 | 4.1 ± 0.9 | .573 | 2.9 ± 1.5 | 3.0 ± 0.8 | .907 | 1.7 ± 0.8 | 3.6 ± 3.7 | .231 | 1.3 ± 0.4 | 1.2 ± 0.3 | .251 | ||||||||
| Heart | 4.6 ± 0.6 | 6.7 ± 0.3 | < .001 | 4.9 ± 0.4 | 6.2 ± 1.2 | .007 | 4.5 ± 1.3 | 5.7 ± 0.7 | .017 | 4.5 ± 0.6 | 5.5 ± 0.5 | < .001 | ||||||||
| Brain | 24.0 ± 3.3 | 32.0 ± 2.5 | < .001 | 21.5 ± 3.2 | 21.9 ± 2.9 | .709 | 17.9 ± 2.8 | 18.6 ± 2.6 | .968 | 13.6 ± 2.7 | 15.6 ± 2.3 | .055 | ||||||||
. | 4 weeks . | . | . | 8 weeks . | . | . | 12 weeks . | . | . | 24 weeks . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | ?/+, n = 19 . | nm/nm, n = 8 . | P . | ?/+, n = 22 . | nm/nm, n = 10 . | P . | ?/+, n = 13 . | nm/nm, n = 8 . | P . | ?/+, n = 19 . | nm/nm, n = 10 . | P . | ||||||||
| Body weight, g | 17.8 ± 2.4 | 11.7 ± 1.2 | < .001 | 21.4 ± 3.4 | 19.1 ± 2.6 | .050 | 25.9 ± 3.7 | 22.4 ± 3.2 | .243 | 35.9 ± 6.1 | 27.2 ± 3.9 | .002 | ||||||||
| Organ-body weight ratio, mg/g | ||||||||||||||||||||
| Liver | 45.1 ± 3.6 | 54.2 ± 2.1 | < .001 | 43.8 ± 5.3 | 50.7 ± 3.1 | < .001 | 40.7 ± 5.1 | 53.1 ± 5.6 | .001 | 42.8 ± 3.1 | 47.8 ± 2.8 | .001 | ||||||||
| Spleen | 3.8 ± 0.8 | 15.4 ± 3.3 | < .001 | 3.4 ± 1.0 | 7.2 ± 2.2 | < .001 | 3.0 ± 1.2 | 7.7 ± 3.6 | .032 | 2.8 ± 1.2 | 5.0 ± 1.3 | < .001 | ||||||||
| Kidneys | 12.0 ± 1.2 | 13.1 ± 1.0 | .028 | 12.6 ± 1.2 | 12.2 ± 1.5 | .384 | 13.1 ± 1.3 | 13.0 ± 1.2 | .708 | 12.3 ± 2.0 | 12.3 ± 1.4 | .985 | ||||||||
| Testes | 6.9 ± 0.8 | 4.5 ± 0.3 | < .001 | 7.5 ± 0.9 | 5.6 ± 1.5 | .149 | 7.8 ± 0.7 | 6.1 ± 0.7 | .018 | 7.0 ± 1.1 | 6.3 ± 0.8 | .149 | ||||||||
| Thymus | 4.3 ± 1.3 | 4.1 ± 0.9 | .573 | 2.9 ± 1.5 | 3.0 ± 0.8 | .907 | 1.7 ± 0.8 | 3.6 ± 3.7 | .231 | 1.3 ± 0.4 | 1.2 ± 0.3 | .251 | ||||||||
| Heart | 4.6 ± 0.6 | 6.7 ± 0.3 | < .001 | 4.9 ± 0.4 | 6.2 ± 1.2 | .007 | 4.5 ± 1.3 | 5.7 ± 0.7 | .017 | 4.5 ± 0.6 | 5.5 ± 0.5 | < .001 | ||||||||
| Brain | 24.0 ± 3.3 | 32.0 ± 2.5 | < .001 | 21.5 ± 3.2 | 21.9 ± 2.9 | .709 | 17.9 ± 2.8 | 18.6 ± 2.6 | .968 | 13.6 ± 2.7 | 15.6 ± 2.3 | .055 | ||||||||
Body weights and ratios of organ to body weight for 129B6F2-?/+ and -nm/nm animals at 4, 8, 12, and 24 weeks of age are reported. Values are presented as the mean ± 1 SD. Statistical significance values (P) are reported for the two-tailed Student t test.