Serum iron parameters and tissue iron stores in ?/+ and nm/nm animals
. | 4 weeks . | . | . | 8 weeks . | . | . | 12 weeks . | . | . | 24 weeks . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter . | ?/+, n = 19 . | nm/nm, n = 8 . | P . | ?/+, n = 14 . | nm/nm, n = 10 . | P . | ?/+, n = 13 . | nm/nm, n = 8 . | P . | ?/+, n = 19 . | nm/nm, n = 10 . | P . | ||||||||
| Serum iron, μg/dL | 166 ± 33 | 246 ± 30 | < .001 | 216 ± 62 | 199 ± 30 | .371 | 148 ± 41 | 121 ± 20 | .136 | 155 ± 55 | 228 ± 54 | .003 | ||||||||
| TIBC, μg/dL | 531 ± 73 | 646 ± 52 | < .001 | 353 ± 48 | 344 ± 59 | .713 | 255 ± 65 | 233 ± 72 | .551 | 311 ± 44 | 339 ± 53 | .178 | ||||||||
| Transferrin saturation, % | 31 ± 5 | 38 ± 3 | .001 | 61 ± 13 | 59 ± 11 | .704 | 56 ± 13 | 55 ± 11 | .600 | 49 ± 15 | 67 ± 10 | .001 | ||||||||
| Liver iron, μg/g | 84 ± 21 | 333 ± 107 | < .001 | 89 ± 16 | 201 ± 51 | < .001 | 95 ± 34 | 136 ± 46 | .273 | 116 ± 53 | 120 ± 60 | .829 | ||||||||
| Spleen iron, μg/g | 90 ± 20 | 50 ± 13 | < .001 | 345 ± 134 | 206 ± 59 | .003 | 618 ± 365 | 261 ± 129 | .014 | 1116 ± 559 | 441 ± 370 | .001 | ||||||||
| Total spleen iron, μg | 5.9 ± 1.7 | 8.7 ± 2.5 | < .001 | 24.3 ± 13.3 | 27.7 ± 12.0 | .522 | 47.9 ± 31.9 | 38.9 ± 13.6 | .330 | 104 ± 68 | 64 ± 73 | .159 | ||||||||
. | 4 weeks . | . | . | 8 weeks . | . | . | 12 weeks . | . | . | 24 weeks . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter . | ?/+, n = 19 . | nm/nm, n = 8 . | P . | ?/+, n = 14 . | nm/nm, n = 10 . | P . | ?/+, n = 13 . | nm/nm, n = 8 . | P . | ?/+, n = 19 . | nm/nm, n = 10 . | P . | ||||||||
| Serum iron, μg/dL | 166 ± 33 | 246 ± 30 | < .001 | 216 ± 62 | 199 ± 30 | .371 | 148 ± 41 | 121 ± 20 | .136 | 155 ± 55 | 228 ± 54 | .003 | ||||||||
| TIBC, μg/dL | 531 ± 73 | 646 ± 52 | < .001 | 353 ± 48 | 344 ± 59 | .713 | 255 ± 65 | 233 ± 72 | .551 | 311 ± 44 | 339 ± 53 | .178 | ||||||||
| Transferrin saturation, % | 31 ± 5 | 38 ± 3 | .001 | 61 ± 13 | 59 ± 11 | .704 | 56 ± 13 | 55 ± 11 | .600 | 49 ± 15 | 67 ± 10 | .001 | ||||||||
| Liver iron, μg/g | 84 ± 21 | 333 ± 107 | < .001 | 89 ± 16 | 201 ± 51 | < .001 | 95 ± 34 | 136 ± 46 | .273 | 116 ± 53 | 120 ± 60 | .829 | ||||||||
| Spleen iron, μg/g | 90 ± 20 | 50 ± 13 | < .001 | 345 ± 134 | 206 ± 59 | .003 | 618 ± 365 | 261 ± 129 | .014 | 1116 ± 559 | 441 ± 370 | .001 | ||||||||
| Total spleen iron, μg | 5.9 ± 1.7 | 8.7 ± 2.5 | < .001 | 24.3 ± 13.3 | 27.7 ± 12.0 | .522 | 47.9 ± 31.9 | 38.9 ± 13.6 | .330 | 104 ± 68 | 64 ± 73 | .159 | ||||||||
Serum iron parameters and tissue nonheme iron stores for 129B6F2-?/+ and -nm/nm animals at 4, 8, 12, and 24 weeks of age are reported. Values are presented as the mean ± 1 SD. Statistical significance values (P) are reported for the two-tailed Student t test.
TIBC indicates total iron binding concentration; total spleen iron = spleen weight × spleen iron.
Conversion factors for SI units are as described for Table 1.