Characteristics of Cancer Patients Who Had Interruptions in Radiotherapy Due to Thrombocytopenia and/or Neutropenia Compared With Controls
| . | Thrombocytopenia Cases (n = 45)* . | Neutropenia Cases (n = 63)* . | Thrombocytopenia + Neutropenia (n = 37)* . | Controls (n = 138) . |
|---|---|---|---|---|
| Mean age (yr) | 54 | 51 | 53.5 | 53 |
| Mean KPS | 83 | 88 | 85 | 86 |
| Mean weight (kg) | 73.3 | 71.4 | 70.9 | 73.6 |
| Sex | ||||
| Male | 27 (60) | 31 (49) | 20 (54) | 72 (52) |
| Female | 18 (40) | 32 (51) | 17 (46) | 66 (48) |
| Type of malignancy | ||||
| Solid tumor | 28 (62) | 36 (57) | 20 (54) | 110 (80) |
| Leukemia/lymphoma | 17 (38)† | 27 (43)‡ | 17 (46)ρ | 28 (20) |
| Extent of disease | ||||
| Local | 6 (13) | 14 (22) | 4 (11) | 51 (37) |
| Regional | 19 (42) | 27 (43) | 16 (43) | 39 (28) |
| Metastatic | 16 (36) | 16 (25) | 13 (35) | 41 (30) |
| Not applicable | 4 (9) | 6 (10) | 4 (11) | 7 (5) |
| Marrow metastases | 5 (11)ρ | 6 (10)† | 5 (13.5)ρ | 2 (1.4) |
| Bone metastases | 12 (27)∥ | 11 (18) | 9 (24) | 20 (15) |
| Brain metastases | 8 (18)ρ | 8 (13)† | 7 (19)ρ | 6 (4) |
| . | Thrombocytopenia Cases (n = 45)* . | Neutropenia Cases (n = 63)* . | Thrombocytopenia + Neutropenia (n = 37)* . | Controls (n = 138) . |
|---|---|---|---|---|
| Mean age (yr) | 54 | 51 | 53.5 | 53 |
| Mean KPS | 83 | 88 | 85 | 86 |
| Mean weight (kg) | 73.3 | 71.4 | 70.9 | 73.6 |
| Sex | ||||
| Male | 27 (60) | 31 (49) | 20 (54) | 72 (52) |
| Female | 18 (40) | 32 (51) | 17 (46) | 66 (48) |
| Type of malignancy | ||||
| Solid tumor | 28 (62) | 36 (57) | 20 (54) | 110 (80) |
| Leukemia/lymphoma | 17 (38)† | 27 (43)‡ | 17 (46)ρ | 28 (20) |
| Extent of disease | ||||
| Local | 6 (13) | 14 (22) | 4 (11) | 51 (37) |
| Regional | 19 (42) | 27 (43) | 16 (43) | 39 (28) |
| Metastatic | 16 (36) | 16 (25) | 13 (35) | 41 (30) |
| Not applicable | 4 (9) | 6 (10) | 4 (11) | 7 (5) |
| Marrow metastases | 5 (11)ρ | 6 (10)† | 5 (13.5)ρ | 2 (1.4) |
| Bone metastases | 12 (27)∥ | 11 (18) | 9 (24) | 20 (15) |
| Brain metastases | 8 (18)ρ | 8 (13)† | 7 (19)ρ | 6 (4) |
Because of rounding, percentages, which are in parentheses, do not always add up to 100%.
Comparison of baseline characteristics for patients who had treatment interruptions due to thrombocytopenia, neutropenia, or both thrombocytopenia and neutropenia when compared with controls yielded P values of † ≤ .05, ‡ ≤ .001, ρ ≤ .01, and ∥ ≤ .1.