Clinical Characteristics and Histologic Subclassification of 116 Patients With DLCL With Results Interpretable for Bcl-2 Protein Expression
| Characteristic . | No. Bcl-2 Positive (%) . | No. Bcl-2 Negative (%) . | P . |
|---|---|---|---|
| Total | 28 (100) | 88 (100) | — |
| Age >60 yr | 7 (25) | 26 (30) | NS |
| Stage III or IV | 13 (46) | 59 (67) | NS |
| Elevated LDH | 25 (89) | 64 (73) | .02 |
| Performance status (ECOG) 2-4 | 6 (21) | 15 (17) | NS |
| Extranodal sites >1 | 7 (25) | 26 (30) | NS |
| BM involvement | 2 (7) | 9 (10) | NS |
| CR rate | 25 (89) | 75 (85) | NS |
| Diffuse mixed | 7 (25) | 10 (11) | NS |
| Diffuse large cell | 20 (71) | 54 (62) | NS |
| IBL | 0 | 16 (18) | NS |
| ALCL | 1 (4) | 8 (9) | NS |
| Characteristic . | No. Bcl-2 Positive (%) . | No. Bcl-2 Negative (%) . | P . |
|---|---|---|---|
| Total | 28 (100) | 88 (100) | — |
| Age >60 yr | 7 (25) | 26 (30) | NS |
| Stage III or IV | 13 (46) | 59 (67) | NS |
| Elevated LDH | 25 (89) | 64 (73) | .02 |
| Performance status (ECOG) 2-4 | 6 (21) | 15 (17) | NS |
| Extranodal sites >1 | 7 (25) | 26 (30) | NS |
| BM involvement | 2 (7) | 9 (10) | NS |
| CR rate | 25 (89) | 75 (85) | NS |
| Diffuse mixed | 7 (25) | 10 (11) | NS |
| Diffuse large cell | 20 (71) | 54 (62) | NS |
| IBL | 0 | 16 (18) | NS |
| ALCL | 1 (4) | 8 (9) | NS |
Abbreviations: IBL, immunoblastic lymphoma; ALCL, anaplastic large cell lymphoma.